Molecular and Cellular Mechanisms of Cancers: Colorectal Cancer

Dear Colleagues,

With over 700,000 deaths world-wide annually, colorectal cancer remains a large societal burden. Our knowledge of the underlying biology of colorectal tumor formation is impressive, but still, we are not able to efficiently fight this disease. Recent insights are that we should not only focus on biological processes that take place in the tumor cell itself, steered by both genetic and epigenetic events, but also on the response of the environment. This Topic Collection aims to focus on that environmental interaction and its steering processes, and on the mechanisms involved in the early and later steps of colorectal cancer development. Finally, we will discuss the conditions that may lead to a better clinical approach to colorectal cancer.

We very much look forward to your contributions.

Dr. Peter Kuppen
Prof. Luca Roncucci
Collection Editors

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