Cellular Senescence and Extracellular Vesicles Crosstalk

Dear Colleagues,

Activation of cellular senescence-associated pathways affect biosynthesis of secreted small extracellular vesicles (EV) and contribute to modifying concentration, size, cargo, and function of plasma EV in aging subjects. Senescent-like EV are functionally active and might induce cellular senescence in “normal” cells, thus contributing to the accumulation of senescent cells, a mechanism that plays a major role in the development and progression of age-related pathologies. Despite this important function, how EV change in response to aging and the underlying mechanisms that contribute to these changes are poorly understood.

The Topical Collection will evaluate manuscripts addressing original research as well as review papers trying to elucidate the role of aging cells in regulating EV content, including RNAs, proteins and lipids and the active role of such component in surrounding cells. Editors will consider studies based on in vitro and in vivo models of senescence as well as approaches envisioning senolytic agents (natural or synthetic) to revert the aging process.

Dr. Lucio Barile
Dr. Edoardo Lazzarini
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.