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Chemosensors
Special Issues
Electrochemical Biosensors: Current Status and Future Perspectives
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Electrochemical Biosensors: Current Status and Future Perspectives

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Electrochemical Devices and Sensors".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 4424

Special Issue Editor

Dr. Wei Zhao

E-Mail Website
Guest Editor
Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China
Interests: electrochemistry; biosensor; single-cell detection

Special Issue Information

Dear Colleagues,

Electrochemical biosensors, as the oldest class of biosensors, have been under development for more than 50 years; despite this, they have always been a vital area of research and application. Its inherent sensitivity makes electrochemistry an excellent technique for biological detection. In recent years, the rapid development of electronics, micromachining technology, and nanotechnology greatly contributed to electrochemical biosensing. In addition to conventional applications in clinical diagnosis, environmental monitoring, and the food industry, electrochemistry has become a state-of-the-art technology in the detection of single entities, as well as the study of electron and energy transfer and molecule migration at micro/nano interfaces. The pursuit of high sensitivity, specificity, accuracy, and spatiotemporal resolution is always the main goal of electrochemical biosensors. Instead of only concentration measurement, researchers have been dedicated to obtaining a deeper understanding of the world using electrochemical biosensing technology. In this Special Issue, we welcome papers focused on not only electrochemical biosensors for the detection of ions, small biomolecules, and cancer biomarkers, but also electrochemical nanoprobes for in vivo applications and single-cell analysis, as well as novel electrochemical-biosensor-based devices.

Dr. Wei Zhao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemistry
  • biosensor
  • clinical diagnosis
  • environmental monitoring
  • food analysis
  • in vivo analysis
  • single-cell detection

Published Papers (2 papers)

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Research

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14 pages, 3227 KiB  
Article
MoS2/MWCNT-COOH-Modified Glassy Carbon Electrode for Nitrite Detection in Water Environment
by Shijie Ren, Yahui Zhang, Ruimiao Qin, Honggang Xu, Minger Ye and Pengcheng Nie
Chemosensors 2022, 10(10), 419; https://doi.org/10.3390/chemosensors10100419 - 13 Oct 2022
Cited by 5 | Viewed by 1920
Abstract
Nitrite is harmful to people and animals when it is excessive in an environment. Traditional detection methods are time-consuming and are generally restricted by sensitivity. In this study, a simple and efficient electrochemical sensor made of a glassy carbon electrode (GCE), modified with [...] Read more.
Nitrite is harmful to people and animals when it is excessive in an environment. Traditional detection methods are time-consuming and are generally restricted by sensitivity. In this study, a simple and efficient electrochemical sensor made of a glassy carbon electrode (GCE), modified with MoS2 nanosheets/carboxylic multiwall carbon nanotubes (MoS2/MWCNT-COOH), was used to detect nitrite. Cyclic voltammetry (CV) was used for drawing the standard curve of nitrite. The properties of the modified materials were analyzed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and electrochemical impedance spectroscopy (EIS). The modified electrode presents a great response to nitrite, shows a wide sensing range (10–10,000 μM) and shows a low detection limit (3.6 μM). The characterization of nanomaterials indicates that MoS2/MWCNT-COOH has a big surface area (150.3 m2 g−1) and abundant pores (pore volume is 0.7085 cm3 g−1). In addition, the sensor shows high sensitivity (0.35 μA μM−1 cm−2), good reproducibility (RSD is 2.2%), and good stability (the responding current only decreased about 4% after 2 weeks). Therefore, the MoS2/MWCNT-COOH-modified electrode is a potential analytical method in nitrite determination. Full article
(This article belongs to the Special Issue Electrochemical Biosensors: Current Status and Future Perspectives)
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Review

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19 pages, 4058 KiB  
Review
Recent Advances in Electrochemiluminescence-Based Single-Cell Analysis
by Qian-Nan He, Zheng-Yuan Ma, Yu-Xin Yang, Cong-Hui Xu and Wei Zhao
Chemosensors 2023, 11(5), 281; https://doi.org/10.3390/chemosensors11050281 - 7 May 2023
Cited by 3 | Viewed by 2051
Abstract
In recent years, the increasing demand for highly sensitive tracking of life processes has promoted scientists to explore advanced analytical techniques. Developing universal analytical methods to detect individual differences and temporal changes among cells is crucial for fundamental study and clinical applications. Among [...] Read more.
In recent years, the increasing demand for highly sensitive tracking of life processes has promoted scientists to explore advanced analytical techniques. Developing universal analytical methods to detect individual differences and temporal changes among cells is crucial for fundamental study and clinical applications. Among existing technologies, the electrochemiluminescence (ECL) approach has attracted attention for various purposes, such as detecting biomolecules, monitoring cellular activities, imaging subcellular structures, and evaluating cell viability. ECL analysis and imaging provide high sensitivity, low background noise, and spatiotemporal resolution for single-cell analysis. In this review, we explore the evolution of ECL technology in cell analysis and emphasize single-cell assays, including detecting released cellular molecules and surface biomarkers, analysing intracellular components, imaging cell membranes, and cell adhesion. We first briefly introduce the mechanism and apparatus for ECL-based single-cell analysis and, subsequently, focus on four aspects of research related to single-cell analysis and imaging. Furthermore, the latest advances in ECL-driven photodynamic therapy and super-resolution ECL microscopy are also discussed. Finally, we discuss the current obstacles and prospects for ECL single-cell analysis. Full article
(This article belongs to the Special Issue Electrochemical Biosensors: Current Status and Future Perspectives)
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