Near-Infrared Fluorophores for Biomedical Research

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Optical Chemical Sensors".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 7403

Special Issue Editor

Department of Chemistry, Portland State University, 1719 SW 10th Avenue, Portland, Oregon, OR 97201, USA
Interests: analytical instrumentation; optical spectroscopy; fluorescence spectroscopy; fluorophores; fluorescent probes; fluorescence imaging; molecular probes; microscopy; separation science; electrophoresis

Special Issue Information

Dear Colleagues,

Fluorescence is a powerful technique that is widely used in fundamental biomedical research and clinical practice. However, there is much room for advancement, as the vast majority of currently known and clinically approved fluorophores function in the ultraviolet or visible region of the electromagnetic spectrum. The performance of traditional fluorophores can suffer in many biomedical applications because short-wavelength light interacts strongly with tissue and the biological sample matrix. These adverse sample interactions are significantly reduced when fluorophores operate at longer wavelengths, especially in the 700–1700 nm near-infrared (NIR) window. NIR fluorophores reduce photon scattering, light absorption, and autofluorescence, which makes them superior alternatives to traditional fluorophores in many biomedical applications. Importantly, the inherent advantages of NIR fluorophores will continue to drive the development of exciting new applications. Thus, the synthesis and applications of novel NIR fluorophores is a vibrant area of emerging research.

This Special Issue on “Near-Infrared Fluorophores for Biomedical Research” will focus on the latest developments and advances in: 1) the synthesis and characterization of novel NIR fluorophores, and/or 2) new applications of NIR fluorescence for fundamental biomedical research or clinical practice. For the purpose of this Issue, NIR will include both the 700–900 nm NIR-I and the 1000–1700 nm NIR-II spectral windows. Deep red fluorophores that show improvement over traditional fluorophores owing to reduced scattering, absorption, or autofluorescence will also be considered. Organic and inorganic materials for in vivo or in vitro applications in biomedical research and clinical practice are invited to participate. Research employing novel long-wavelength small-molecule organic fluorophores including BODIPY, cyanine, oxazine, rhodamine, squaraine, xanthene, and their derivatives; as well as research involving macromolecules and materials including carbon nanotubes, conjugated polymers, inorganic nanoparticles, quantum dots, or rare-earth-doped materials are of particular interest, and are strongly encouraged to participate in this Special Issue.

Dr. Mark Lowry
Guest Editor

Manuscript Submission Information

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Keywords

  • fluorophores
  • fluorescent probes
  • NIR-I
  • NIR-II
  • near-infrared fluorophores
  • near-infrared fluorescence
  • BODIPY
  • cyanine
  • oxazine
  • rhodamine
  • squaraine
  • xanthene
  • carbon nanotubes
  • conjugated polymer
  • inorganic nanoparticles
  • quantum dots
  • rare-earth-doped materials

Published Papers (2 papers)

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Research

14 pages, 2519 KiB  
Article
Red-Shifted Environmental Fluorophores and Their Use for the Detection of Gram-Negative Bacteria
by Alicia Megia-Fernandez, Maxime Klausen, Bethany Mills, Gillian E. Brown, Heather McEwan, Neil Finlayson, Kevin Dhaliwal and Mark Bradley
Chemosensors 2021, 9(6), 117; https://doi.org/10.3390/chemosensors9060117 - 21 May 2021
Cited by 2 | Viewed by 2642
Abstract
Two novel, water-soluble, merocyanine fluorophores were readily prepared by microwave-assisted synthesis. Full optical characterization was performed in a series of protic and aprotic solvents, and the dyes displayed fluorescence in the red region with up to a 20-fold decrease in brightness in water, [...] Read more.
Two novel, water-soluble, merocyanine fluorophores were readily prepared by microwave-assisted synthesis. Full optical characterization was performed in a series of protic and aprotic solvents, and the dyes displayed fluorescence in the red region with up to a 20-fold decrease in brightness in water, demonstrating a strong environmental sensitivity hereby termed as solvato-fluorogenicity (to distinguish from solvatochromism). Shorter fluorescent lifetimes were also measured in water, which confirmed this character. These dyes were conjugated to a modified polymyxin scaffold that allowed fluorescence “switch-on” upon binding to Gram-negative bacterial membranes, and selective fluorescence detection of bacteria in a wash-free protocol. Full article
(This article belongs to the Special Issue Near-Infrared Fluorophores for Biomedical Research)
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13 pages, 3027 KiB  
Article
Carbon Dots Fluorescence-Based Colorimetric Sensor for Sensitive Detection of Aluminum Ions with a Smartphone
by Wei Wei, Juan Huang, Wenli Gao, Xiangyang Lu and Xingbo Shi
Chemosensors 2021, 9(2), 25; https://doi.org/10.3390/chemosensors9020025 - 29 Jan 2021
Cited by 30 | Viewed by 4072
Abstract
In this work, blue emission carbon dots (CDs) are synthesized in the one-pot solvothermal method using naringin as precursor. The CDs are used to develop a ratiometric fluorescence sensor for the sensitive analysis of Al3+ with a detection limit of 113.8 nM. [...] Read more.
In this work, blue emission carbon dots (CDs) are synthesized in the one-pot solvothermal method using naringin as precursor. The CDs are used to develop a ratiometric fluorescence sensor for the sensitive analysis of Al3+ with a detection limit of 113.8 nM. A fluorescence emission peak at 500 nm gradually appears, whereas the original fluorescence peak at 420 nm gradually decreases upon the increase in the Al3+ concentration. More importantly, the obvious color change of the CDs probe from blue to green under a 360 nm UV lamp can be identified by a smartphone and combined with the RGB (red/green/blue) analysis. This results in a visual and sensitive analysis of Al3+ with a detection limit of 5.55 μM. Moreover, the high recovery is in the 92.46–104.10% range, which demonstrates the high accuracy of this method for actual samples’ analysis. The use of a smartphone and the RGB analysis greatly simplifies the operation process, saves equipment cost, shortens the detection time, and provides a novel method for the instant, on-site, visual detection of Al3+ in actual samples. Full article
(This article belongs to the Special Issue Near-Infrared Fluorophores for Biomedical Research)
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