cimb-logo

Journal Browser

Journal Browser

Radiation-Induced Cellular and Molecular Responses

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 603

Special Issue Editor

Special Issue Information

Dear Colleagues,

Radiation exposure, whether from environmental sources, medical treatments, or occupational hazards, has profound effects on biological systems. The impact of radiation on cells and tissues can lead to complex molecular responses, driving efforts to understand these processes for better therapeutic and protective strategies.

This Special Issue invites original research and review articles that delve into molecular pathways, including DNA damage and repair, signal transduction, apoptosis, autophagy, and cellular senescence induced by radiation. We also welcome studies on the role of non-coding RNAs, epigenetic modifications, and molecular markers in radiation response. Research on the development of novel radioprotective agents and strategies to mitigate radiation-induced damage is particularly encouraged. By gathering cutting-edge research, this Special Issue aims to provide comprehensive insights into the molecular underpinnings of radiation effects, contributing to the development of more effective therapeutic interventions and protective measures.

We invite contributions from researchers across the fields of molecular biology, biochemistry, oncology, and related disciplines to enhance our understanding of radiation-induced biological responses and their implications for human health.

Dr. Carlo Aprile
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiation
  • radiobiology
  • space radiobiology
  • heavy ions carcinogenesis
  • LinearNonTreshold
  • radionuclide therapy
  • alpha emitters
  • beta emitters
  • radiobiology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

15 pages, 744 KiB  
Review
Molecular Insights into Radiation Effects and Protective Mechanisms: A Focus on Cellular Damage and Radioprotectors
by Blanca Ibáñez, Ana Melero, Alegría Montoro, Nadia San Onofre and Jose M. Soriano
Curr. Issues Mol. Biol. 2024, 46(11), 12718-12732; https://doi.org/10.3390/cimb46110755 - 9 Nov 2024
Viewed by 373
Abstract
Ionizing radiation has been a critical tool in various fields, such as medicine, agriculture, and energy production, since its discovery in 1895. While its applications—particularly in cancer treatment and diagnostics—offer significant benefits, ionizing radiation also poses risks due to its potential to cause [...] Read more.
Ionizing radiation has been a critical tool in various fields, such as medicine, agriculture, and energy production, since its discovery in 1895. While its applications—particularly in cancer treatment and diagnostics—offer significant benefits, ionizing radiation also poses risks due to its potential to cause molecular and cellular damage. This damage can occur through the direct ionization of biological macromolecules, such as deoxyribonucleic acid (DNA), or indirectly through the radiolysis of water, which generates reactive oxygen species (ROS) that further damage cellular components. Radioprotectors, compounds that protect against radiation-induced damage, have been extensively researched since World War II. These agents work by enhancing DNA repair, scavenging free radicals, and boosting antioxidant defenses, thereby protecting healthy tissues. Furthermore, some radioprotective agents also stimulate DNA repair mechanisms even after radiation exposure, aiding in recovery from radiation-induced damage. This article explores the molecular mechanisms of radiation-induced damage, focusing on both direct and indirect effects on DNA, and discusses the role of radioprotectors, their mechanisms of action, and recent advancements in the field. The findings underscore the importance of developing effective radioprotective strategies, particularly in medical and industrial settings, where radiation exposure is prevalent. Full article
(This article belongs to the Special Issue Radiation-Induced Cellular and Molecular Responses)
Show Figures

Figure 1

Back to TopTop