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Advances in Bioinformatics and Molecular Research on Alzheimer’s Disease

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 589

Special Issue Editor


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Guest Editor
1. Bioinformatics & Neuroinformatics, School of Science & Technology, Hellenic Open University, 26331 Patras, Greece
2.Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, Greece
Interests: machine learning; biomedical data mining; biological complex systems modeling; network medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD) is a complex neurodegenerative disorder influenced by a multitude of genetic, molecular, and environmental factors. Recent advances in bioinformatics have revolutionized our ability to analyze and interpret vast amounts of data, providing new insights into the molecular mechanisms underlying AD. This Special Issue explores cutting-edge bioinformatics tools and molecular research strategies that are reshaping our understanding of Alzheimer’s disease. Key topics include the integration of multi-omics data, such as genomics, transcriptomics, and proteomics, to uncover biomarkers and therapeutic targets. Additionally, innovative computational approaches are highlighted for their role in identifying disease pathways, predicting disease progression, and enabling personalized medicine. By combining bioinformatics with experimental molecular studies, researchers are uncovering novel insights that may lead to early diagnosis, targeted interventions, and improved patient outcomes. This Special Issue serves as a platform for researchers to share advancements in computational and molecular biology, fostering collaboration and innovation in the fight against Alzheimer’s disease.

Dr. Aristidis G. Vrahatis
Guest Editor

Manuscript Submission Information

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Keywords

  • Alzheimer’s disease
  • single-cell sequencing
  • molecular biomarkers
  • single-cell RNA-seq
  • single-cell ATAC-seq
  • spatial transcriptomics

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Published Papers (1 paper)

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Research

15 pages, 26587 KB  
Article
Effects of a Natural Polyherbal Extract on Alleviating Scopolamine-Induced Memory Deficits in C57BL/6 Mice via Enhancing Cholinergic Function
by Hyeokjin Kwon, Min Ho Kwon, Myeongguk Jeong, Yeeun Kim, Hae-Gyung Yoon, Yeongdon Ju, Kyung-Yae Hyun and Go-Eun Choi
Curr. Issues Mol. Biol. 2025, 47(10), 817; https://doi.org/10.3390/cimb47100817 - 2 Oct 2025
Abstract
Alzheimer’s disease (AD) is a progressive neurological condition with limited effective pharmaceutical treatments, often accompanied by side effects. This has increased interest in plant-based alternatives. This study examined the cognitive effects of a Natural Polyherbal Extract (NPX) on scopolamine-induced memory deficits in mice. [...] Read more.
Alzheimer’s disease (AD) is a progressive neurological condition with limited effective pharmaceutical treatments, often accompanied by side effects. This has increased interest in plant-based alternatives. This study examined the cognitive effects of a Natural Polyherbal Extract (NPX) on scopolamine-induced memory deficits in mice. Male C57BL/6 mice (10 weeks old, n = 36) were divided into four groups: control (saline), scopolamine (1 mg/kg, i.p.), tacrine (10 mg/kg, oral), and NPX (1000 mg/kg, oral). NPX and tacrine were administered daily by oral gavage for two weeks. Cognitive function was assessed weekly using the Y-maze task. Brain tissues were collected for biochemical analysis, including AChE activity and immunohistochemical detection of neurodegeneration-related markers. Results: Mice treated with NPX demonstrated improved spontaneous alternation behavior compared to the scopolamine group. NPX also significantly reduced acetylcholinesterase activity. Immunohistochemistry revealed decreased expression of amyloid-beta (Aβ) and caspase-3, with enhanced choline acetyltransferase levels. These outcomes were comparable to those observed in the tacrine-treated group. Conclusions: NPX alleviated scopolamine-induced memory impairment through enhancement of cholinergic signaling and mitigation of neurodegenerative markers. The findings suggest that NPX may serve as a promising plant-derived candidate for managing memory-related disorders, including AD. Full article
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