Molecular Diagnostics, Pathology and Biomarkers of Neurodevelopmental Disorders
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 6161
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition: DSM-5 defines neurodevelopmental disorders as “a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning”. NDDs are a heterogeneous group of disorders that are rather difficult to characterize because they present with diverse symptoms. They are very widespread, severely hampering the life of those affected and their families and the entire society as a whole. Despite the increasing focus in this field, mechanisms responsible for abnormal brain function in NDDs are still not fully understood, necessitating further research to improve the quality of life of individuals with NDDs.
This Special Issue will include following topics:
- Genetic regulation of expansion of neocortex;
- The role of radial glia signaling in development of NDDs;
- The role of neuroinflammation, particularly microglia signaling in development of NNDs;
- Molecular mechanisms of sexual dimorphism in NDDs;
- Molecular biomarkers of NDDs;
- Experimental models of NDDs;
- Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) differentiation into neuronal line as 2D in vitro models of neurodevelopmental disorders;
- Use of brain organoids (stem cell-derived self-organized 3D tissues) that mimic the cytoarchitecture, cellular composition as well as gene expression of the fetal human brain as D model of NDDs;
- Rodent models of NDDs.
Dr. Bartosz Bielecki
Guest Editor
Manuscript Submission Information
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Keywords
- radial glia
- neuronal progenitors
- microglia
- neuroinflammation
