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Molecular Insights: Mechanisms Underlying the Biological Activities of Natural Products

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 742

Special Issue Editor


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Guest Editor
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
Interests: natural products research; drug discovery and development; signaling pathways; target identification; immune modulation; cancer treatment and prevention; diabetic nephropathy

Special Issue Information

Dear Colleagues,

The Special Issue titled "Molecular Insights: Mechanisms Underlying the Biological Activities of Natural Products" aims to delve into the intricate molecular mechanisms that govern the diverse biological activities of natural products. It seeks to provide a comprehensive understanding of how these compounds interact with molecular targets, cellular components, and signaling pathways, while also influencing gene expression and metabolic processes to elicit physiological responses in organisms. Through elucidating these mechanisms, researchers aim to comprehend the broad spectrum of biological effects exerted by natural products, including, but not limited to, immune modulation, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Molecular studies offer insights into the structural features of natural products that contribute to their pharmacological properties, informing drug discovery, nutraceutical development, and therapeutic interventions. This understanding is crucial for maximizing the therapeutic potential of natural products and advancing their use in medicine and other fields.

Topics of interest include, but are not limited to, the pharmacodynamics, pharmacokinetics, target identification, and mode of action of natural products. By uncovering these molecular insights, this Special Issue strives to shed light on the therapeutic potential of natural products in various fields such as medicine, agriculture, and environmental science. Researchers are encouraged to contribute original research articles, reviews, and perspectives that contribute to our understanding of the molecular basis underlying the biological activities of natural products.

Dr. Premalatha Balachandran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • molecular mechanisms
  • biological activities
  • pharmacodynamics
  • drug discovery
  • therapeutic potential
  • signaling pathways
  • target identification
  • pharmacological properties
  • bioactive compounds

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Published Papers (1 paper)

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Research

19 pages, 3071 KiB  
Article
Effects of Heat-Induced Oxidative Stress and Astaxanthin on the NF-kB, NFE2L2 and PPARα Transcription Factors and Cytoprotective Capacity in the Thymus of Broilers
by Donna Lee Kuehu, Yuanyuan Fu, Masaki Nasu, Hua Yang, Vedbar S. Khadka and Youping Deng
Curr. Issues Mol. Biol. 2024, 46(8), 9215-9233; https://doi.org/10.3390/cimb46080544 - 22 Aug 2024
Viewed by 455
Abstract
The thymus, a central lymphoid organ in animals, serves as the site for T cell development, differentiation and maturation, vital to adaptive immunity. The thymus is critical for maintaining tissue homeostasis to protect against tumors and tissue damage. An overactive or prolonged immune [...] Read more.
The thymus, a central lymphoid organ in animals, serves as the site for T cell development, differentiation and maturation, vital to adaptive immunity. The thymus is critical for maintaining tissue homeostasis to protect against tumors and tissue damage. An overactive or prolonged immune response can lead to oxidative stress from increased production of reactive oxygen species. Heat stress induces oxidative stress and overwhelms the natural antioxidant defense mechanisms. This study’s objectives were to investigate the protective properties of astaxanthin against heat-induced oxidative stress and apoptosis in the chicken thymus, by comparing the growth performance and gene signaling pathways among three groups: thermal neutral, heat stress, and heat stress with astaxanthin. The thermal neutral temperature was 21–22 °C, and the heat stress temperature was 32–35 °C. Both heat stress groups experienced reduced growth performance, while the astaxanthin-treated group showed a slightly lesser decline. The inflammatory response and antioxidant defense system were activated by the upregulation of the NF-kB, NFE2L2, PPARα, cytoprotective capacity, and apoptotic gene pathways during heat stress compared to the thermal neutral group. However, expression levels showed no significant differences between the thermal neutral and heat stress with antioxidant groups, suggesting that astaxanthin may mitigate inflammation and oxidative stress damage. Full article
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