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The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1608

Special Issue Editors

Dr. Ioannis Tsamesidis

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Interests: oxidative stress; laboratory hematology; nanoparticles; stem cells differentiation
Special Issues, Collections and Topics in MDPI journals
Dr. Evangelia Stalika

E-Mail Website
Guest Editor
1. Lab of Computing, Medical Informatics and Biomedical Imaging Technologies, School of Medicine, AUTH, 54124 Thessaloniki, Greece
2. Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: oxidative stress; reactive oxygen species; antioxidants; genetic profile; immunity; disease pathogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The rapid development of new approaches and techniques in molecular biology has led to new insights in medicine regarding clinical applications and biomaterial science for tissue engineering approaches. More specifically, investigative methods within molecular biology have made progress in uncovering fundamental medical processes that are revealed when we fully understand their molecular details. Cloning tools, CRISPR/Cas9 technology, DNA arrays and next-generation sequencing (NGS) are some of the tools used in guiding drug discovery and developing diagnostic methods. The information that arises thanks to their use, in addition to patients’ reported outcomes, covers all the elements that we must take into consideration in routine clinical decision-making strategies to optimize treatment benefits for patients. Additionally, as molecular biologists progressively discover the pathogenetic mechanisms that underly several entities, evidence regarding the correct combination of extracellular and intracellular chemical gradients, cellular attachment complexes and other stimuli required to activate tissue regeneration is revealed. The aim of this Special Issue is to gather relevant new insights and updates from the fields of medicine, biomaterials and tissue engineering under the prism of molecular biology tools to obtain a more comprehensive view of the obstacles and challenges that are raised.

You can read the first volume of our Special Issue by clicking the following link:

https://www.mdpi.com/journal/cimb/special_issues/0SJG097B17

Dr. Ioannis Tsamesidis
Dr. Evangelia Stalika
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicine
  • biomaterials
  • tissue engineering
  • molecular biology
  • patients’ reported outcomes
  • personalized medicine

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Published Papers (4 papers)

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Research

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11 pages, 5164 KiB  
Article
The Proliferation of Chang Liver Cells After Simulated Microgravity Induction
by Huy Nghia Quang Hoang, Chi Nguyen Quynh Ho, Loan Thi Tung Dang, Nhan Lu Chinh Phan, Chung Chinh Doan, Han Thai Minh Nguyen, Cuong Phan Minh Le, Son Nghia Hoang and Long Thanh Le
Curr. Issues Mol. Biol. 2025, 47(3), 164; https://doi.org/10.3390/cimb47030164 - 27 Feb 2025
Viewed by 516
Abstract
This study aimed to assess the recovery capability of Chang liver cells (CCL-13) following simulated microgravity (SMG) induction. CCL-13 cells were cultured under SMG conditions for 72 h, and control group cells were cultured under 1G conditions for an identical duration. Cells from [...] Read more.
This study aimed to assess the recovery capability of Chang liver cells (CCL-13) following simulated microgravity (SMG) induction. CCL-13 cells were cultured under SMG conditions for 72 h, and control group cells were cultured under 1G conditions for an identical duration. Cells from the SMG and control groups were further cultured under 1G conditions and assessed after 24 h and 72 h intervals in the gravity recovery experiment. The WST1 results indicated that CCL-13 proliferation was more evident in the control group than in the SMG group after both the 24 h and 72 h intervals. The control group had a lower percentage of CCL-13 cells in the G0/G1 phase compared with the SMG group at both time points, and it exhibited a higher total percentage of cells in the S and G2/M phases. The control group exhibited elevated levels of cell-cycle-related proteins, including cyclin A, cyclin D, and cdk6, compared with the SMG group. The flow cytometry results revealed that the apoptotic rate in the control group was significantly lower than that in the SMG group at both the 24 h and 72 h time points. However, the apoptotic percentage in the SMG group at the 72-h mark was significantly lower than that at the 24-h mark. SMG reduces the viability and proliferation ability of CCL-13 cells. After a period of recovery and adaptation to normal gravity conditions (1G), the CCL-13 cells in the SMG group showed better signs of recovery after 72 h than after 24 h. Full article
(This article belongs to the Special Issue The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition)
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Review

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20 pages, 738 KiB  
Review
Research Progress on the Preparation and Application of Decellularized Tendons
by Jing Li, Mingxing Wen, Sujuan Zhang, Lingfei Du, Xin Fan, Hao Liang, Hong Wang, Jing Sun, Yuchun Ding, Liangpeng Ge, Jideng Ma and Jinwei Zhang
Curr. Issues Mol. Biol. 2025, 47(4), 251; https://doi.org/10.3390/cimb47040251 - 6 Apr 2025
Viewed by 278
Abstract
Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields [...] Read more.
Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields of tissue engineering and regenerative medicine in recent years. This paper summarizes the origin, structure, and ECM components of animal tendons, reviews decellularization methods, and discusses recent advancements in the research and applications of decellularized tendons. Furthermore, it explores future development trends of xenogeneic decellularized tendon materials, aiming to provide a reference for fundamental research and the development of biomaterials related to decellularized tendons. Full article
(This article belongs to the Special Issue The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition)
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19 pages, 897 KiB  
Review
Orthobiologics Revisited: A Concise Perspective on Regenerative Orthopedics
by Fábio Ramos Costa, Luyddy Pires, Rubens Andrade Martins, Márcia Santos, Gabriel Silva Santos, João Vitor Lana, Bruno Ramos Costa, Napoliane Santos, Alex Pontes de Macedo, André Kruel and José Fábio Lana
Curr. Issues Mol. Biol. 2025, 47(4), 247; https://doi.org/10.3390/cimb47040247 - 2 Apr 2025
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Abstract
At the forefront of regenerative medicine, orthobiologics represent a spectrum of biological substances that offer promising alternatives for tissue repair and regeneration. Traditional surgical treatments often involve significant risks, extended recovery periods, and may not fully restore tissue functionality, creating a strong demand [...] Read more.
At the forefront of regenerative medicine, orthobiologics represent a spectrum of biological substances that offer promising alternatives for tissue repair and regeneration. Traditional surgical treatments often involve significant risks, extended recovery periods, and may not fully restore tissue functionality, creating a strong demand for less invasive options. This paper presents a concise overview of orthobiologics, reexamining their role within the broader landscape of regenerative medicine. Beginning with a brief introduction to orthobiologics, the paper navigates through various types of biological materials and their associated mechanisms of action and clinical applications. By highlighting platelet derivatives, bone marrow-derived products, and processed adipose tissue, among others, it underscores the pivotal role of orthobiologics in prompting biological responses like cellular proliferation, differentiation, and angiogenesis, thereby fostering tissue healing. Furthermore, this paper explores the diverse applications of orthobiologics in orthopedic conditions, outlining their utility in the treatment of bone and soft-tissue injuries. Addressing clinical considerations, it discusses safety profiles, efficacy, patient selection criteria, and emerging challenges. With the limitations of traditional medicine becoming more apparent, orthobiologics offer an innovative and less invasive approach to patient care. Looking forward, this paper approaches future directions in orthobiologics research, emphasizing the need for continued innovation and exploration. Through a concise perspective, this paper aims to provide clinicians, researchers, and stakeholders with a comprehensive understanding of orthobiologics and their evolving role in regenerative medicine. Full article
(This article belongs to the Special Issue The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition)
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11 pages, 471 KiB  
Review
The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?
by Fábio Ramos Costa, Sergio Augusto Lopes de Souza, Rubens Andrade Martins, Bruno Ramos Costa, Luyddy Pires, Alex Pontes de Macedo, Napoliane Santos, Stephany Cares Huber, Gabriel Silva Santos, André Kruel, Márcia Santos and José Fábio Lana
Curr. Issues Mol. Biol. 2025, 47(4), 239; https://doi.org/10.3390/cimb47040239 - 29 Mar 2025
Viewed by 262
Abstract
Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation process, resulting in a liquid [...] Read more.
Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation process, resulting in a liquid matrix enriched with fibrin, leukocytes, and growth factors. These components promote tissue regeneration, angiogenesis, and anti-inflammatory responses, making i-PRF suitable for bone and cartilage repair as well as drug delivery systems. This review discusses the history, biological mechanisms, and clinical applications of i-PRF in orthopedics, highlighting its potential advantages over traditional platelet-rich plasma (PRP). Furthermore, we address the challenges and limitations of i-PRF, including drug stability, release control, and bioactive interactions, underscoring the need for further research to optimize its therapeutic efficacy. Full article
(This article belongs to the Special Issue The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition)
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