The Molecular Roles of CD4+ T Cell Subsets in Neuropathological Diseases—Unraveling Diverse Interactions and Therapeutic Potentials

Dear Colleagues,

We are pleased to announce a call for papers for a Special Issue in the MDPI Journal CIMB on the topic “The Molecular Roles of CD4+ T Cell Subsets in Neurodegenerative Diseases”. This Special Issue aims to comprehensively explore the multifaceted roles of CD4+ T cell subsets, including Th17, Th1, Th2, Th9, and Th22, in the pathogenesis of various neurodegenerative disorders.

Neurodegenerative diseases, such as multiple sclerosis, Parkinson’s, Alzheimer’s, and depression, involve complex immune responses that impact neuronal integrity and function. Th17 and Th1 cells have emerged as key pro-inflammatory mediators, driving chronic neuroinflammation and contributing to neuronal damage and astrogliosis in several neurodegenerative conditions. Conversely, Th2 cells may exert regulatory effects, modulating the inflammatory response and potentially providing neuroprotection. The roles of Th9 and Th22 cells in these diseases remain less explored, and a deeper understanding of their contributions to neuroinflammation could unveil novel therapeutic targets. Additionally, regulatory T cells (Treg) hold significant promise as they exhibit potent anti-inflammatory properties, suppress excessive immune responses, and maintain immune tolerance.

In this Special Issue, we invite original research articles, reviews, and perspective pieces that delve into the molecular mechanisms underlying the interactions of CD4+ T cell subsets with neural components, including neurons, glia, astrocytes, pericytes oligodendrocytes, and the blood–brain barrier (BBB). Topics of interest include but are not limited to:

• Signaling pathways and immune responses initiated by CD4+ T cell subsets in neurodegenerative diseases;
• Crosstalk between CD4+ T cells and neural cells influencing neuroinflammation and neuronal and/or glial damage;
• Implications of CD4+ T cell dysregulation on BBB integrity and permeability;
• Therapeutic potentials of targeting CD4+ T cell subsets, including Treg, to mitigate neuroinflammation and preserve neural function.

Dr. Michel-Edwar Mickael
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.