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Nutrients: From the Organism’s Responses to Molecular Biology

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Dear Colleagues,

Understanding the cellular and molecular mechanisms underlying nutrients’ biological effects has become a priority for shedding new light on the human body’s homeostasis and for preventing diseases. Through their chemical and structural diversity, nutrients and their derived products interfere with all biological processes and may therefore be considered in all biological studies. Recent studies have demonstrated that nutrients may not only be considered minor actors of cell biology since they behave as transcription factor ligands and as enzymes’ activity regulators, and their binding to cellular or extracellular receptors can result in dedicated intracellular pathways. Biological responses to the same nutrient may also differ according to the physiological state, cellular type, etc.

This Special Issue aims to explore how biological responses are regulated by nutrients through these pathways and cross-regulations. Special interest will thus be given to articles written in an integrative approach in the analysis of nutrients’ roles in a biological response or in the analysis of the pleiotropic response at the whole, and cellular levels to a nutrient or a nutrient’s family. In this issue, reviews articles and original research articles are welcome.

Research areas may include but are not restricted to immunology, neurobiology, oncology, pharmacology, vascular biology, physiology, endocrinology, development, aging, etc.

I look forward to receiving your contributions.

Dr. Nathalie Guriec
Guest Editor

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Keywords

nutrients
transduction pathways
epigenetics
diseases
integrative response
cross-regulation

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20 pages, 4470 KiB

Open AccessArticle

Methionine Sources Differently Affect Production of Reactive Oxygen Species, Mitochondrial Bioenergetics, and Growth of Murine and Quail Myoblasts In Vitro

by Katja Stange, Toni Schumacher, Claudia Miersch, Rose Whelan, Martina Klünemann and Monika Röntgen

Curr. Issues Mol. Biol. 2023, 45(4), 2661-2680; https://doi.org/10.3390/cimb45040174 - 23 Mar 2023

Cited by 1 | Viewed by 1389

Abstract

An optimal supply of L-methionine (L-Met) improves muscle growth, whereas over-supplementation exerts adverse effects. To understand the underlying mechanisms, this study aims at exploring effects on the growth, viability, ROS production, and mitochondrial bioenergetics of C2C12 (mouse) and QM7 (quail) myoblasts additionally supplemented (100 or 1000 µM) with L-Met, DL-methionine (DL-Met), or DL-2-hydroxy-4-(methylthio)butanoic acid (DL-HMTBA). In both cell lines, all the supplements stimulated cell growth. However, in contrast to DL-Met, 1000 µM of L-Met (C2C12 cells only) or DL-HMTBA started to retard growth. This negative effect was stronger with DL-HMTBA and was accompanied by significantly elevated levels of extracellular H₂O₂, an indicator for OS, in both cell types. In addition, oversupplementation with DL-HMTBA (1000 µM) induced adaptive responses in mitochondrial bioenergetics, including reductions in basal (C2C12 and QM7) and ATP-synthase-linked (C2C12) oxygen consumption, maximal respiration rate, and reserve capacity (QM7). Only QM7 cells switched to nonmitochondrial aerobic glycolysis to reduce ROS production. In conclusion, we found a general negative effect of methionine oversupplementation on cell proliferation. However, only DL-HMTBA-induced growth retardation was associated with OS and adaptive, species–specific alterations in mitochondrial functionality. OS could be better compensated by quail cells, highlighting the role of species differences in the ability to cope with methionine oversupplementation. Full article

(This article belongs to the Special Issue Nutrients: From the Organism’s Responses to Molecular Biology)

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