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Innate Immunity Responds to Virus Infection

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 501

Special Issue Editor


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Guest Editor
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Interests: coronaviruses; alphaviruses; flaviviruses; vaccines; infectious diseases; innate immunology; CRISPR screening; host factors; antibodies

Special Issue Information

Dear Colleagues,

As the first line of host defense against pathogens, the innate immune system utilizes pattern-recognition receptors (PRRs) to detect the invasion of viruses and initiate host antiviral responses such as the production of type I interferons and proinflammatory cytokines. On the other hand, viruses have developed various mechanisms to evade the innate immune system and utilize various mechanisms that are advantageous for viral replication. Thus, understanding the detailed interaction mechanisms between host factors and viruses can provide invaluable information and may shed new light on therapeutic options for the various viral infection-related diseases. This Special Issue will focus on the latest research findings at the molecular level, cellular level and in vivo animal models during the viral infection of various viruses (such as coronaviruses, alphaviruses, flaviviruses, etc.). In addition, this Special Issue is especially interested in long-term chronic infection with multiple viruses.

Dr. Zhenlu Chong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral infection
  • cGAS-STING
  • RIG-I
  • toll-like receptors
  • IFN-I
  • IFN-III
  • JAK-STAT pathway
  • ubiquitination
  • cellular and molecular studies
  • animal model

Published Papers (1 paper)

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Review

14 pages, 916 KiB  
Review
African Swine Fever Virus Immunosuppression and Virulence-Related Gene
by Tao Huang, Fangtao Li, Yingju Xia, Junjie Zhao, Yuanyuan Zhu, Yebing Liu, Yingjuan Qian and Xingqi Zou
Curr. Issues Mol. Biol. 2024, 46(8), 8268-8281; https://doi.org/10.3390/cimb46080488 - 31 Jul 2024
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Abstract
African swine fever virus (ASFV), a highly contagious pathogen characterized by a complex structure and a variety of immunosuppression proteins, causes hemorrhagic, acute, and aggressive infectious disease that severely injures the pork products and industry. However, there is no effective vaccine or treatment. [...] Read more.
African swine fever virus (ASFV), a highly contagious pathogen characterized by a complex structure and a variety of immunosuppression proteins, causes hemorrhagic, acute, and aggressive infectious disease that severely injures the pork products and industry. However, there is no effective vaccine or treatment. The main reasons are not only the complex mechanisms that lead to immunosuppression but also the unknown functions of various proteins. This review summarizes the interaction between ASFV and the host immune system, along with the involvement of virulence-related genes and proteins, as well as the corresponding molecular mechanism of immunosuppression of ASFV, encompassing pathways such as cGAS-STING, nuclear factor kappa–light-chain-enhancer of activated B cells (NF-κB), Janus Kinase (JAK) and JAK Signal Transducers and Activators of Transcription (STAT), apoptosis, and other modulation. The aim is to summarize the dynamic process during ASFV infection and entry into the host cell, provide a rational insight into development of a vaccine, and provide a better clear knowledge of how ASFV impacts the host. Full article
(This article belongs to the Special Issue Innate Immunity Responds to Virus Infection)
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