Linking Genomic Changes with Cancer in the NGS Era, 2nd Edition
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioinformatics and Systems Biology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 991
Special Issue Editors
Interests: pathology; histology; cancer; biomakers; molecular biology; cytology
Interests: prostate cancer; inherited cancer predisposition; DNA-repair; molecular tumor subtypes; targeted cancer therapeutics; CRISPR/Cas9 gene editing; functional assays
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The arrival and evolution of next-generation sequencing (NGS) technology has enlarged our capacity to read genetic code in-depth, beginning a new era in the identification of disease-causing genetic changes. While our ability to “read” individual genetic changes has dramatically increased, the “translationability” of the identified changes is complex, and the establishment of a new driver gene/variant constitutes a NGS-based genetic screening bottleneck. This is particularly true in cancer, where only a very small fraction of the 10–20% of the cancers associated with familial aggregation have a known underlying genetic cause. Moreover, the profile of genomic changes in the 80–90% of the cancers arising sporadically is highly heterogeneous, making it difficult to distinguish driving, secondary and progression-associated genomic variation.
In this Special Issue, we invite researchers to submit their work highlighting or discarding the identification of new genes/variants as a cause of cancer development or progression. Evidence may include case–control studies, segregation analysis, gene/variant specific gene editing (CRISPR/Cas9 or other), protein structure analysis, functional studies, or other approaches considered relevant for validation of a gene–disease association.
You can read the publications in the first volume of our Special Issue here:
https://www.mdpi.com/journal/cimb/special_issues/genomic_cancer_
Prof. Dr. Javier Azúa-Romeo
Dr. Paula Paulo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- next-generation sequencing (NGS)
- genetic variation
- driver gene
- functional validation
- gene editing
- cancer
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
