Linking Genomic Changes with Cancer in the NGS Era, 2nd Edition
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioinformatics and Systems Biology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 1285
Special Issue Editors
Interests: pathology; histology; cancer; biomakers; molecular biology; cytology
Interests: prostate cancer; inherited cancer predisposition; DNA-repair; molecular tumor subtypes; targeted cancer therapeutics; CRISPR/Cas9 gene editing; functional assays
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The arrival and evolution of next-generation sequencing (NGS) technology has enlarged our capacity to read genetic code in-depth, beginning a new era in the identification of disease-causing genetic changes. While our ability to “read” individual genetic changes has dramatically increased, the “translationability” of the identified changes is complex, and the establishment of a new driver gene/variant constitutes a NGS-based genetic screening bottleneck. This is particularly true in cancer, where only a very small fraction of the 10–20% of the cancers associated with familial aggregation have a known underlying genetic cause. Moreover, the profile of genomic changes in the 80–90% of the cancers arising sporadically is highly heterogeneous, making it difficult to distinguish driving, secondary and progression-associated genomic variation.
In this Special Issue, we invite researchers to submit their work highlighting or discarding the identification of new genes/variants as a cause of cancer development or progression. Evidence may include case–control studies, segregation analysis, gene/variant specific gene editing (CRISPR/Cas9 or other), protein structure analysis, functional studies, or other approaches considered relevant for validation of a gene–disease association.
You can read the publications in the first volume of our Special Issue here:
https://www.mdpi.com/journal/cimb/special_issues/genomic_cancer_
Prof. Dr. Javier Azúa-Romeo
Dr. Paula Paulo
Guest Editors
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Keywords
- next-generation sequencing (NGS)
- genetic variation
- driver gene
- functional validation
- gene editing
- cancer
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