Molecular Mechanisms of the Neuro-Musculoskeletal System
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 870
Special Issue Editor
Interests: nuclear domain; sarcomere; telocyte; muscle-tendon perimeter; aquatic training; joint immobilization
Special Issue Information
Dear Colleagues,
The musculoskeletal system contains two microscopic junctions that are essential for skeletal muscle function: the myotendinous and the neuromuscular junction. These junctions play key roles in force transmission and muscle contraction and can be affected by direct and indirect stimuli, which compromise their plasticity, organization, and structural integrity. The neuromuscular junction is where communication occurs between the peripheral nervous system and muscle fibers. It is vital for the transmission of nerve impulses and the release of neurotransmitters. In contrast, the myotendinous junction consists of sarcoplasmic evaginations and invaginations, and is the main region of force transmission within the locomotor apparatus that exhibits high plasticity. Preserving the integrity of these junctions is crucial for maintaining muscle function and overall locomotor health.
This Special Issue aims to expand knowledge and present original research regarding the mechanism, morphology, and molecular aspects of neuromuscular and myotendinous junctions, considering the effects of neurodegenerative diseases and protocols that aim to explore the adaptations of these regions, affected directly and indirectly. In addition, studies that address therapeutic methodologies in the face of protocols in experimental models and in humans that contribute through preventive or healing methods to their remodeling, such as physical exercise.
Dr. Adriano Polican Ciena
Guest Editor
Manuscript Submission Information
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Keywords
- morphology
- molecular biology
- microscopy
- neuromuscular junction
- myotendinous junction
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