Aging, Age-Related Changes in the Brain and the Progression of Alzheimer’s Disease
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 28006
Special Issue Editor
Interests: cell death; cell differentiation; bone remodeling; Alzheimer; aging; glycative stress; oxidative stress; redox biology
Special Issue Information
Dear Colleagues,
This Special Issue will concentrate on the aging process in in vitro, animal, or human models, the resulting changes in cellular and molecular levels, structural and functional changes of proteins, lipids, genes, enzymes, and their relationship with the development of Alzheimer’s disease (AD). As glycative stress, oxidative stress, and ER stress are reported to be elevated with age, this elevation may accelerate the progression of AD. Amyloid-beta production, deposition, and plaque formation may not be the only reasons behind the progression of AD, as there could be other proteins responsible that are unknown so far. Most often, we focus on the upregulated genes, but the downregulated genes may be the cause we usually neglect. Environmental factors, pollutants, food habits, lifestyle, alcohol consumption, and smoking could accelerate or slow down AD pathogenesis. We are still searching for the best lifestyle to avoid or slow down AD. There is a possibility, for example, that drugs currently being used for the treatment of other diseases may lead to better controlling AD, but there have been no research studies to confirm this as of yet. Human, animal, or microbial enzymes may have the potential to clear the amyloid plaque. Bioinformatics tools may help to identify new targets or design and develop new effective drug candidates for clinical trials.
This Special Issue welcomes original research or review articles focused on the cellular and molecular events upon aging that promote the onset and advancement of AD.
Dr. A. N. M. Mamun-Or-Rashid
Guest Editor
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Keywords
- Alzheimer’s disease
- aging, glycative and oxidative stress
- risk factors
- Neuroinflammation
- neurodegeneration
- lifestyle
- food habits
- pollution
- therapeutic approaches
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