Circadian Rhythm Disorders in the Era of Circadian Medicine

A special issue of Clocks & Sleep (ISSN 2624-5175). This special issue belongs to the section "Disorders".

Deadline for manuscript submissions: closed (25 May 2022) | Viewed by 3551

Special Issue Editor


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Guest Editor
Centre for Chronobiology, University of Basel, Basel, Switzerland
Interests: clinical research in the field of sleep ad circadian medicine; interplay between circadian and general health, with focus on mental health; public health aspects of chronobiology and sleep; innovative therapeutic approaches to sleep and circadian rhythm disorders
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Special Issue Information

Dear Colleagues,

Disorders of circadian rhythms, which result from a misalignment between an individual's internal clock and the required timing of daily activities, have traditionally been considered to primarily impact sleep, for example, in shift work or jet lag disorder. There is now strong evidence, however, showing that the alteration of a proper circadian organization (circadian health) either between the internal clocks and external time cues, or between multiple internal clocks, is involved in the pathophysiological models of a variety of conditions beyond classical sleep–wake disorders, including cardiometabolic conditions (diabetes, hypertension, obesity, cardiovascular disease), breast and prostate cancer, neurodegenerative disorders (Alzheimer's and Parkinson's diseases), and depression and mood disorders. When considering the current global health emergency caused by the ongoing pandemic, circadian science has shown that circadian mechanisms are implicated in the complex interaction between host and virus and in influenza-related lung inflammation, and that circadian disruption is associated with dysregulation of inflammatory and immune responses. Therefore, circadian health is rapidly establishing itself as a key factor for the success of preventive and treatment strategies in future personalized circadian medicine. Topics of this issue include but are not limited to the following:

  • Pathophysiological mechanisms of circadian rhythm disorders (CRDs);
  • Clinical management of CRDs, from diagnosis to treatment;
  • Impact of CRDs on public health and society.

Dr. Corrado Garbazza, MD
Guest Editor

Manuscript Submission Information

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Keywords

  • chronobiology
  • circadian rhythm disorders
  • chronotherapy
  • light
  • melatonin
  • circadian medicine
  • sleep medicine
  • sleep–wake rhythm disorders

Published Papers (1 paper)

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Research

11 pages, 933 KiB  
Article
Circadian Alterations Increase with Progression in a Patient-Derived Cell Culture Model of Breast Cancer
by Hui-Hsien Lin, Stephanie R. Taylor and Michelle E. Farkas
Clocks & Sleep 2021, 3(4), 598-608; https://doi.org/10.3390/clockssleep3040042 - 12 Nov 2021
Cited by 2 | Viewed by 2928
Abstract
Circadian rhythm disruption can elicit the development of various diseases, including breast cancer. While studies have used cell lines to study correlations between altered circadian rhythms and cancer, these models have different genetic backgrounds and do not mirror the changes that occur with [...] Read more.
Circadian rhythm disruption can elicit the development of various diseases, including breast cancer. While studies have used cell lines to study correlations between altered circadian rhythms and cancer, these models have different genetic backgrounds and do not mirror the changes that occur with disease development. Isogenic cell models can recapitulate changes across cancer progression. Hence, in this study, a patient-derived breast cancer model, the 21T series, was used to evaluate changes to circadian oscillations of core clock protein transcription as cells progress from normal to malignant states. Three cell lines were used: H16N2 (normal breast epithelium), 21PT (atypical ductal hyperplasia), and 21MT-1 (invasive metastatic carcinoma). The cancerous cells are both HER2+. We assessed the transcriptional profiles of two core clock proteins, BMAL1 and PER2, which represent a positive and negative component of the molecular oscillator. In the normal H16N2 cells, both genes possessed rhythmic mRNA oscillations with close to standard periods and phases. However, in the cancerous cells, consistent changes were observed: both genes had periods that deviated farther from normal and did not have an anti-phase relationship. In the future, mechanistic studies should be undertaken to determine the oncogenic changes responsible for the circadian alterations found. Full article
(This article belongs to the Special Issue Circadian Rhythm Disorders in the Era of Circadian Medicine)
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