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Advances in the Surface Modification of the Biomedical Metal Materials
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Advances in the Surface Modification of the Biomedical Metal Materials

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 9478

Special Issue Editor

Dr. Qiang Wang

E-Mail Website
Guest Editor
School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, China
Interests: biomaterials; surface modification of Ti-based alloys; bio-inspired materials; additive manufacturing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute an original, innovative research work or review to this Special Issue on “Advances in the Surface Modification of the Biomedical Metal Materials”.

Surface modification of biomedical metal materials is directly related to most biological reactions, such as cell behavior. In recent years, new metals such as Cu-bearing, Zn-bearing, and Mg-bearing alloys are designed and developed. Additive manufacturing supplies an effective method for the fabrication of many kinds of alloys. The surface modification of newly developed alloys is a hot area. Therefore, the highlighted biofunctional surface may lay a foundation to develop novel biomaterials and push new alloys to clinical applications. The aim of this Special Issue is to present current research in the development and application of surface modification of biofunctional metals through original research and review articles from leading groups around the world.

In particular, the topics of interest include but are not limited to:

  1. The surface modification of Ti-based medical alloys;
  2. The surface modification of Mg-based medical alloys;
  3. Design and development of biofunctional surfaces and coatings of biomaterials which contain Cu, Zn or Mg elements;
  4. Functional surface and coating inspired from nature;
  5. Characterization of complex biological surfaces.

We look forward to receiving your contribution!

Dr. Qiang Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical metal
  • biofunctional surface
  • bone regeneration
  • antibacterial activity

Published Papers (4 papers)

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Research

10 pages, 2330 KiB  
Article
Surface Modification of WE43 Magnesium Alloys with Dopamine Hydrochloride Modified GelMA Coatings
by Yang Ji, Mengdie Hou, Jin Zhang, Tianlin Wang, Can Cao, Huazhe Yang and Xiaodong Zhang
Coatings 2022, 12(8), 1074; https://doi.org/10.3390/coatings12081074 - 29 Jul 2022
Cited by 3 | Viewed by 2062
Abstract
As biodegradable medical implants, magnesium alloys have attracted great concerns due to their desirable biological and mechanical performances. Nevertheless, the overfast degradation rate of magnesium alloys makes it difficult to make full use of their potential in medical sciences. Therefore, it is a [...] Read more.
As biodegradable medical implants, magnesium alloys have attracted great concerns due to their desirable biological and mechanical performances. Nevertheless, the overfast degradation rate of magnesium alloys makes it difficult to make full use of their potential in medical sciences. Therefore, it is a hot issue to control the degradation rate and functionalize the magnesium alloys via surface modifications. Herein, methacrylate gelatin (GelMA) hydrogel was adopted as coatings on the surface of WE43 magnesium alloys to control the degradation behaviors of magnesium alloys. Inspired by mussels, dopamine (DOPA) hydrochloride was adopted to modify GelMA to further functionalize the coatings. The compositions, swelling properties, degradation behaviors, and morphologies of samples were characterized by UV-Vis spectrophotometer, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and immersion test. It was shown that GelMA-DOPA composites could be obtained and the swelling and degradation behaviors of magnesium alloys could be controlled by adjusting the compositions of GelMA and DOPA. Furthermore, the GelMA-DOPA hydrogel coatings can be tightly bonded to the Mg alloys. Full article
(This article belongs to the Special Issue Advances in the Surface Modification of the Biomedical Metal Materials)
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15 pages, 5425 KiB  
Article
Corrosion Behavior of TiNi Alloy Fabricated by Selective Laser Melting in Simulated Saliva
by Chenfan Jia, Xinyu Wang, Ming Hu, Yucheng Su, Shujun Li, Xin Gai and Liyuan Sheng
Coatings 2022, 12(6), 840; https://doi.org/10.3390/coatings12060840 - 15 Jun 2022
Cited by 8 | Viewed by 1602
Abstract
In this work, TiNi samples were prepared by Selective Laser Melting (SLM) technology, and the influence of microstructure, fluoride ion, and pH value on corrosion behavior in a saline environment was investigated and compared with TiNi alloy fabricated by traditional forging technology. The [...] Read more.
In this work, TiNi samples were prepared by Selective Laser Melting (SLM) technology, and the influence of microstructure, fluoride ion, and pH value on corrosion behavior in a saline environment was investigated and compared with TiNi alloy fabricated by traditional forging technology. The results indicated that the corrosion resistance of the SLM sample was slightly superior to that of the wrought sample in a saline environment due to the uniform and dense oxide film formed on the SLM sample surface. However, in acidic Artificial Saliva Solution (ASS) containing fluoride ions, the corrosion current density of the SLM sample increased from 9.85 × 10−2 to 13.9 μA/cm2 because of the presence of F−. Fluorine ions disrupted the passive film on the surface, and the Ti-F compound formed in the film, which deteriorated the corrosion resistance of the SLM sample. The increase in fluoride concentration and the decrease in pH value could accelerate the corrosion of the SLM sample. Full article
(This article belongs to the Special Issue Advances in the Surface Modification of the Biomedical Metal Materials)
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15 pages, 3155 KiB  
Article
Shear Bond Strength and Microleakage of Pit and Fissure Sealants Placed after Saliva-Contaminated Etched Enamel
by Zhifan Bao, Hui Sun, Dongyang Fan, Xin Wang and Qiang Wang
Coatings 2022, 12(4), 441; https://doi.org/10.3390/coatings12040441 - 24 Mar 2022
Cited by 4 | Viewed by 2682
Abstract
Saliva contamination of etched enamel before sealant application is the most common reason for failure of fissure sealants, thus affecting the effect of caries prevention. This study aimed to evaluate the shear bond strength (SBS) and microleakage of resin-based fissure sealant on saliva-contaminated [...] Read more.
Saliva contamination of etched enamel before sealant application is the most common reason for failure of fissure sealants, thus affecting the effect of caries prevention. This study aimed to evaluate the shear bond strength (SBS) and microleakage of resin-based fissure sealant on saliva-contaminated etched enamel after rinsing, re-etching, and applying universal adhesive. Fifty human third molars were sectioned into 2 parts and embedded in acrylic resin to obtained 100 samples. The samples were randomly assigned to 5 groups: 1, etching; 2, etching + contamination; 3, etching + contamination + rinsing; 4, etching + contamination+ re-etching; 5, etching + contamination + universal adhesive. Each group was divided into 2 subgroups: 24 h storage and 5000× thermocycling. After measuring SBS, failure mode was analyzed. In an additional 15 teeth, microleakage was tested using dye penetration method. Three more teeth were used for scanning electron microscope (SEM) observation of the enamel surface morphology in each group. The adhesive group had significantly higher mean SBS after 24 h storage, while the re-etching group were better after 5000× thermocycling. The etching, etching+ contamination+ re-etching, and etching+ contamination+ universal adhesive groups showed the least microleakage. The SEM reveals considerable variations in the enamel surface appearance within groups. Re-etching or applying universal adhesive in saliva-contaminated etched enamel before sealant can achieve satisfactory results. Considering the less operative steps and the shorter chair time, applying universal adhesive is more recommended for a pediatric patient if saliva-contamination happened before sealant application. Full article
(This article belongs to the Special Issue Advances in the Surface Modification of the Biomedical Metal Materials)
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13 pages, 3538 KiB  
Article
The Effects of Graphene on the Biocompatibility of a 3D-Printed Porous Titanium Alloy
by Xu Sun, Shuang Tong, Shude Yang and Shu Guo
Coatings 2021, 11(12), 1509; https://doi.org/10.3390/coatings11121509 - 8 Dec 2021
Cited by 9 | Viewed by 2519
Abstract
3D-printed titanium (Ti) materials have attracted much attention in the field of bone tissue repair. However, the combination strength of traditional alloy materials with bone tissue is lower, and the elastic modulus is higher than that of natural bone tissue, which makes the [...] Read more.
3D-printed titanium (Ti) materials have attracted much attention in the field of bone tissue repair. However, the combination strength of traditional alloy materials with bone tissue is lower, and the elastic modulus is higher than that of natural bone tissue, which makes the titanium alloy susceptible to stress shielding phenomena after implantation. Therefore, it is urgent to find better surface modification technology. In this study, the physical and chemical properties, toxicity, and proliferation of adipose stem cells of composite graphene-coated titanium alloy (Gr–Ti) were investigated using 3D-printed titanium alloy as a material model. Physical and chemical property tests confirmed that 3D printing could produce porous titanium alloy materials; the compressive strength and elastic modulus of the titanium alloy scaffolds were 91 ± 3 MPa and 3.1 ± 0.4 GPa, matching the elastic modulus of normal bone tissue. The surface characterization shows that graphene can be coated on titanium alloy by a micro-arc oxidation process, which significantly improves the surface roughness of titanium alloy. The roughness factor (Ra) of the Ti stent was 4.95 ± 1.12 μm, while the Ra of the Gr–Ti stent was 6.37 ± 0.72 μm. After the adipose stem cells were co-cultured with the scaffold for 4 h and 24 h, it was found that the Gr–Ti scaffold could better promote the early cell adhesion. CCK-8 tests showed that the number of ADSCs on the G–Ti scaffold was significantly higher than that on the Ti scaffold (p < 0.01). The relative growth rate (RGR) of ADSCs in Gr–Ti was grade 0–1 (non-toxic). In the in vivo experiment of repairing a critical bone defect of a rabbit mandible, the bone volume fraction in the Gr–Ti group increased to 49.42 ± 3.28%, which was much higher than that in the Ti group (39.76 ± 3.62%) (p < 0.05). In conclusion, the porous graphene–titanium alloy promotes the proliferation and adhesion of adipose stem cells with multidirectional differentiation potential, which has great potential for the application of bone tissue engineering in repairing bone defects in the future. Full article
(This article belongs to the Special Issue Advances in the Surface Modification of the Biomedical Metal Materials)
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