Novel Biomarkers and Liver Cancer

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 891

Special Issue Editors


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Guest Editor
ncRNA, Epigenetics and Genome Fluidity, CNRS UMR3244, Sorbonne University, PSL University, Institut Curie, Centre de Recherche, Paris, France
Interests: long non-coding RNA; signal transduction; liver cancer; extracellular vesicles; transcription regulation

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Guest Editor
Inserm, Univ Rennes 1, OSS (Oncogenesis, Stress, Signaling) Laboratory, UMR_S 1242, Centre de Lutte contre le Cancer Eugène Marquis, F-35042 Rennes, France
Interests: hepatocellular carcinoma; cholangiocarcinoma; cell plasticity; TGFβ signaling; circular RNA
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Special Issue Information

Dear Colleagues,

Liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is one of the main causes of cancer-related deaths, with an increasing incidence and mortality over recent years. Controlling liver cancer progression is a laborious task, due to its asymptomatic nature in the early stages of the disease. For advanced HCC, chemotherapeutic drugs, such as sorafenib and lenvatinib, have been widely used, resulting in the modest improvement of patients’ life expectancy, accompanied by serious side effects. Recently, immunotherapy has been established as a new line of treatment for HCC; however, only some patients efficiently respond to it. Therefore, the identification of novel molecules that can serve as diagnostic or prognostic biomarkers is of paramount importance.

In this Special Issue, we invite researchers and clinicians to publish original research articles or reviews within the scope of liver cancer biomarker identification that could potentially contribute to improved prognoses and enhance the prediction of therapy response.

We look forward to receiving your contributions.

Dr. Panagiotis Papoutsoglou
Dr. Cédric Coulouarn
Guest Editors

Manuscript Submission Information

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Keywords

  • biomarker
  • hepatocellular carcinoma
  • cholangiocarcinoma
  • prognosis
  • therapy response

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Published Papers (1 paper)

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Research

10 pages, 1735 KiB  
Article
Low CD8+ Density Variation and R1 Surgical Margin as Independent Predictors of Early Post-Resection Recurrence in HCC Patients Meeting Milan Criteria
by Rokas Stulpinas, Ieva Jakiunaite, Agne Sidabraite, Allan Rasmusson, Dovile Zilenaite-Petrulaitiene, Kestutis Strupas, Arvydas Laurinavicius and Aiste Gulla
Curr. Oncol. 2024, 31(9), 5344-5353; https://doi.org/10.3390/curroncol31090394 - 10 Sep 2024
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Abstract
Our study included 41 patients fulfilling the Milan criteria preoperatively and aimed to identify individuals at high risk of post-resection HCC relapse, which occurred in 18 out of 41 patients (43.9%), retrospectively. We analyzed whole slide images of CD8 immunohistochemistry with automated segmentation [...] Read more.
Our study included 41 patients fulfilling the Milan criteria preoperatively and aimed to identify individuals at high risk of post-resection HCC relapse, which occurred in 18 out of 41 patients (43.9%), retrospectively. We analyzed whole slide images of CD8 immunohistochemistry with automated segmentation of tissue classes and detection of CD8+ lymphocytes. The image analysis outputs were subsampled using a hexagonal grid-based method to assess spatial distribution of CD8+ lymphocytes with regards to the epithelial edges. The CD8+ lymphocyte density indicators, along with clinical, radiological, post-surgical and pathological variables, were tested to predict HCC relapse. Low standard deviation of CD8+ density along the tumor edge and R1 resection emerged as independent predictors of shorter recurrence-free survival (RFS). In particular, patients presenting with both adverse predictors exhibited 100% risk of relapse within 200 days. Our results highlight the potential utility of integrating CD8+ density variability and surgical margin to identify a high relapse-risk group among Milan criteria-fulfilling HCC patients. Validation in cohorts with core biopsy could provide CD8+ distribution data preoperatively and guide preoperative decisions, potentially prioritizing liver transplantation for patients at risk of incomplete resection (R1) and thereby improving overall treatment outcomes significantly. Full article
(This article belongs to the Special Issue Novel Biomarkers and Liver Cancer)
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