Application of Nuclear Medicine in Cancer Diagnosis and Treatment

A special issue of Current Oncology (ISSN 1718-7729).

Deadline for manuscript submissions: 15 April 2025 | Viewed by 701

Special Issue Editor


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Guest Editor
Department of Advanced Biomedical Sciences, University of Naples, Federico II, 80131 Naples, Italy
Interests: nuclear medicine; peptide receptor radionuclide therapy; endocrinology; oncology; computed tomography
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Special Issue Information

Dear Colleagues,

Nuclear medicine has rapidly advanced in recent times. In just thirty years, it has made two significant leaps forward and is now on the brink of another breakthrough that could significantly affect cancer treatment within the coming years.

In the 1990s, FDG-PET revolutionized nuclear medicine by using a radioactive glucose analogue to detect cancer cells, becoming the standard for detecting cancer. In the early 2000s, hybrid imaging techniques like PET/CT, SPECT/CT, and PET/MRI further advanced the field, combining different technologies to improve patient care and detection of abnormalities.

Nuclear imaging is entering a new era called theranostics, combining cancer diagnosis, monitoring, and treatment. This approach utilizes new radiopharmaceuticals that specifically bind to and destroy tumor cells, targeting difficult-to-treat cancers like gastroenteropancreatic neuroendocrine tumors and metastatic castration-resistant prostate cancer.

I invite researchers to address this topic, providing insightful findings on the known and new applications of nuclear medicine in cancer diagnosis and treatment.

Dr. Michele Klain
Guest Editor

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Keywords

  • PET/CT
  • imaging
  • nuclear medicine
  • cancer diagnosis

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Published Papers (1 paper)

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Research

13 pages, 2268 KiB  
Article
The Safety and Efficacy of Peptide Receptor Radionuclide Therapy for Gastro-Entero-Pancreatic Neuroendocrine Tumors: A Single Center Experience
by Leandra Piscopo, Emilia Zampella, Fabio Volpe, Valeria Gaudieri, Carmela Nappi, Erica Di Donna, Stefania Clemente, Antonio Varallo, Mariano Scaglione, Alberto Cuocolo and Michele Klain
Curr. Oncol. 2024, 31(9), 5617-5629; https://doi.org/10.3390/curroncol31090416 - 18 Sep 2024
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Abstract
The aim of the present study was to evaluate the safety and efficacy of radionuclide therapy with [177Lu]Lu-DOTA-TATE according to our single center experience at the University of Naples Federico II. For the present analysis, we considered 21 patients with progressive, [...] Read more.
The aim of the present study was to evaluate the safety and efficacy of radionuclide therapy with [177Lu]Lu-DOTA-TATE according to our single center experience at the University of Naples Federico II. For the present analysis, we considered 21 patients with progressive, advanced, well-differentiated G1 and G2 in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) treated with [177Lu]Lu-DOTA-TATE according to the decisions of a multidisciplinary team. All patients underwent four cycles of 7–8 GBq of [177Lu]Lu-DOTA-TATE every 8 weeks. A whole-body scan (WBS) was performed 4, 48, and 168 h after each treatment. The dosimetry towards the organ at risk and target lesions was calculated. For each patient, renal and bone marrow parameters were evaluated before, during, and 3 months after the end of the treatment. Follow-up data were obtained and RECIST criteria were considered as the endpoint. Among 21 patients enrolled (mean age 65 ± 9 years); 17 (81%) were men and the small intestine was the most frequent location of disease (n = 12). A mild albeit significant variation (p < 0.05) in both platelets and white blood cell counts among all time points was observed, despite it disappearing 3 months after the end of the therapy. According to the RECIST criteria, 11 (55%) patients had a partial response to therapy and 8 (40%) had stable disease. Only one (5%) patient had disease progression 4 months after treatment. Our data confirm that [177Lu]Lu-DOTA is safe and effective in controlling the burden disease of G1/G2 GEP-NETs patients. Full article
(This article belongs to the Special Issue Application of Nuclear Medicine in Cancer Diagnosis and Treatment)
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