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Current Oncology
Special Issues
Long-Term Effects of Systemic Therapies on Cancer Patients
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Long-Term Effects of Systemic Therapies on Cancer Patients

A special issue of Current Oncology (ISSN 1718-7729).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 11114

Special Issue Editor

Dr. Andrew G. Robinson

E-Mail Website
Guest Editor
Departments of Oncology, Queen's University, Kingston, ON K7L 5P9, Canada
Interests: breast cancer; lung cancer; translational research; predictive and prognostic biomarkers; cancer treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chemotherapy and hormonal therapy have been the cornerstone of systemic therapy for cancer patients for the past 70 years, while, more recently, targeted therapy, monoclonal antibody therapy, and immunotherapy have seen significant increases in use. Given the increasing incidence of cancer, the changing age demographics of the affected population, the increased indications for therapies in earlier stages of disease, and the increased efficacy of recent therapies, there is a growing number of long-term survivors who have been treated with systemic chemotherapy, immunotherapy, hormonal therapy, and targeted therapy. This Special Issue focuses on the long-term effects of these therapies that require special attention in cancer survivors.

Dr. Andrew G. Robinson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • late effects
  • survivorship
  • toxicity
  • immunotherapy
  • targeted therapy
  • chemotherapy hormonal therapy

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Published Papers (3 papers)

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Research

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10 pages, 967 KiB  
Article
Evaluation of Patient-Reported Symptoms and Functioning after Treatment for Endometrial Cancer
by Monika Sobočan, Dorotea Gašpar, Estera Gjuras and Jure Knez
Curr. Oncol. 2022, 29(8), 5213-5222; https://doi.org/10.3390/curroncol29080414 - 22 Jul 2022
Cited by 2 | Viewed by 2103
Abstract
The overall survival of women with endometrial cancer is excellent after management. Different management strategies are associated with variable patient-reported outcomes (PROs). Evaluating PROs in the follow-up period can aid in better counseling and intervention for PRO improvement. This study aimed to evaluate [...] Read more.
The overall survival of women with endometrial cancer is excellent after management. Different management strategies are associated with variable patient-reported outcomes (PROs). Evaluating PROs in the follow-up period can aid in better counseling and intervention for PRO improvement. This study aimed to evaluate the properties of the Slovenian translation of the EORTC QLQ-EN24 assessment scale. Women treated at the University Medical Centre Maribor, Slovenia, between January 2016 and December 2019 were invited to report their symptoms using the EORTC QLQ-EN24 questionnaire. Data were correlated with treatment modalities and clinical characteristics. The median age of participants in our study was 61 years old. PROs were not specific to therapy or clinical characteristics. Overall, women who more frequently reported gastrointestinal symptoms, muscular pain, or back pain also had statistically more frequently decreased levels of PROs in other assessed areas. Women who reported sexual or vaginal problems more often reported significantly poorer body images. Sexual activity within 4 weeks prior to completing the scale was reported by 39% of women. Sexual functioning assessments also showed important correlations between sexual interest, enjoyment, and activity. Individualized follow-ups addressing PROs should be offered to better address concerns and improve long-term outcomes in women with endometrial cancer. Full article
(This article belongs to the Special Issue Long-Term Effects of Systemic Therapies on Cancer Patients)
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Review

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15 pages, 748 KiB  
Review
Chemotherapy-Induced Neuropathy and Diabetes: A Scoping Review
by Mar Sempere-Bigorra, Iván Julián-Rochina and Omar Cauli
Curr. Oncol. 2021, 28(4), 3124-3138; https://doi.org/10.3390/curroncol28040273 - 19 Aug 2021
Cited by 15 | Viewed by 4413
Abstract
Although cancer and diabetes are common diseases, the relationship between diabetes, neuropathy and the risk of developing peripheral sensory neuropathy while or after receiving chemotherapy is uncertain. In this review, we highlight the effects of chemotherapy on the onset or progression of neuropathy [...] Read more.
Although cancer and diabetes are common diseases, the relationship between diabetes, neuropathy and the risk of developing peripheral sensory neuropathy while or after receiving chemotherapy is uncertain. In this review, we highlight the effects of chemotherapy on the onset or progression of neuropathy in diabetic patients. We searched the literature in Medline and Scopus, covering all entries until 31 January 2021. The inclusion and exclusion criteria were: (1) original article (2) full text published in English or Spanish; (3) neuropathy was specifically assessed (4) the authors separately analyzed the outcomes in diabetic patients. A total of 259 papers were retrieved. Finally, eight articles fulfilled the criteria, and four more articles were retrieved from the references of the selected articles. The analysis of the studies covered the information about neuropathy recorded in 768 cancer patients with diabetes and 5247 control cases (non-diabetic patients). The drugs investigated are chemotherapy drugs with high potential to induce neuropathy, such as platinum derivatives and taxanes, which are currently the mainstay of treatment of various cancers. The predisposing effect of co-morbid diabetes on chemotherapy-induced peripheral neuropathy depends on the type of symptoms and drug used, but manifest at any drug regimen dosage, although greater neuropathic signs are also observed at higher dosages in diabetic patients. The deleterious effects of chemotherapy on diabetic patients seem to last longer, since peripheral neuropathy persisted in a higher proportion of diabetic patients than non-diabetic patients for up to two years after treatment. Future studies investigating the risk of developing peripheral neuropathy in cancer patients with comorbid diabetes need to consider the duration of diabetes, cancer-induced neuropathic effects per se (prior chemotherapy administration), and the effects of previous cancer management strategies such as radiotherapy and surgery. Full article
(This article belongs to the Special Issue Long-Term Effects of Systemic Therapies on Cancer Patients)
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Other

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8 pages, 845 KiB  
Case Report
An Example of Personalized Treatment in HR+ HER2+ Long Survivor Breast Cancer Patient (Case Report)
by Martina Panebianco, Beatrice Taurelli Salimbeni, Michela Roberto and Paolo Marchetti
Curr. Oncol. 2021, 28(3), 1980-1987; https://doi.org/10.3390/curroncol28030184 - 25 May 2021
Cited by 2 | Viewed by 3793
Abstract
Background. Personalized therapy is becoming increasingly popular in oncological scenarios, not only based on molecular pharmacological targets, but also preventing any drug–drug–gene interaction (DDGI), which could lead to severe toxicities. Single nucleotide polymorphisms (SNPs), the individual germline sequence variations in genes involved in [...] Read more.
Background. Personalized therapy is becoming increasingly popular in oncological scenarios, not only based on molecular pharmacological targets, but also preventing any drug–drug–gene interaction (DDGI), which could lead to severe toxicities. Single nucleotide polymorphisms (SNPs), the individual germline sequence variations in genes involved in drug metabolism, are correlated to interindividual response to drugs and explain both efficacy and toxicity profiles reported by patients. Case presentation. We present the case of a woman suffering from triple-positive breast cancer; she had early-stage disease at the onset and after four years developed metastatic disease. During her history, she presented different toxicities due to antineoplastic treatments. Particularly, hypertransaminasemia was found during every line of treatment. Nevertheless, we were able to guarantee the patient an excellent therapeutic adhesion thanks to the supportive treatments and the reduction of drug dosage. Moreover, we conducted a simultaneous analysis of the patient’s biochemical and genomic data thanks to Drug-PIN software, and we found several significant SNPs of the main enzymes and transporters involved in drug metabolism. Conclusion. Our case report demonstrated the relevance of DDGI in clinical practice management of a patient treated for advanced breast cancer, suggesting the role of Drug-PIN software as an easy-to-use tool to prevent adverse events during cancer treatment and to help physicians in therapeutic algorithms. However, further studies are needed to confirm these results. Full article
(This article belongs to the Special Issue Long-Term Effects of Systemic Therapies on Cancer Patients)
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