Bioinorganic Chemistry in Drug Discovery
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Editors
Dr. Tanja Soldatović
Dr. Tanja Soldatović
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Department of Natural-Mathematical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia
Interests: bioinorganic chemistry; medicinal inorganic chemistry; heterometallic complexes; biomolecules interactions; mechanism of antitumor activity
Special Issues, Collections and Topics in MDPI journals
Dr. Snežana Jovanović-Stević
Dr. Snežana Jovanović-Stević
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University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, 34000 Kragujevac, Serbia
Interests: transition metal complexes; kinetics; biomolecules; interactions
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear Colleagues,
Bioinorganic chemistry is an interdisciplinary field that examines the role of essential micro- and macro-elements in biological systems. Many processes in living systems such as metabolism, respiration, photosynthesis, growth, reproduction, muscle contraction, etc., cannot take place without the presence of some metal ions. Bioinorganic chemistry connects inorganic chemistry with organic chemistry in addition to synthesizing the new complex compounds of transition metal ions, which are used as therapeutic and diagnostic agents. This field includes studies of kinetic and thermodynamic interactions between transition metal ions coordination compounds and biomolecules such as enzymes, nucleic acids, proteins, peptides, amino acids, and others. Furthermore, bioinorganic chemistry connects inorganic chemistry with biology and medicine during investigation in vitro and in vivo potential appropriate therapeutic agents, as well as, in examination of transport of these compounds through the cell membrane and elimination of them from biological systems using appropriate ligand by forming the stable complex compounds. This Special Issue presents recent progress in the field of bioinorganic chemistry in drug discovery with many new approaches to the design of innovative metal-based drugs and includes recent discovery of investigations of the bioinorganic processes.
Dr. Tanja Soldatovic
Dr. Snezana Jovanovic-Stevic
Collection Editors
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Keywords
- bioinorganic
- drug discovery
- metal-based drugs
- anticancer agents
- interactions
Published Papers (1 paper)
2023
Open AccessReview
Therapeutic Perspectives of Metal Nanoformulations
by
Tawhida Islam, Md. Mizanur Rahaman, Md. Nayem Mia, Iffat Ara, Md. Tariqul Islam, Thoufiqul Alam Riaz, Ana C. J. Araújo, João Marcos Ferreira de Lima Silva, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Edlane Martins de Andrade, Muhammad Ali Khan, Henrique D. M. Coutinho, Zakir Husain and Muhammad Torequl Islam
Cited by 7 | Viewed by 2612
Abstract
In recent decades, acceptance of nanoparticles (NPs) in therapeutic applications has increased because of their outstanding physicochemical features. By overcoming the drawbacks of conventional therapy, the utilization of metal NPs, metal-oxide, or metal supported nanomaterials have shown to have significant therapeutic applications in
[...] Read more.
In recent decades, acceptance of nanoparticles (NPs) in therapeutic applications has increased because of their outstanding physicochemical features. By overcoming the drawbacks of conventional therapy, the utilization of metal NPs, metal-oxide, or metal supported nanomaterials have shown to have significant therapeutic applications in medicine. This is proved by a lot of clinical and laboratory investigations that show improved treatment outcomes, site-specific drug delivery, and fewer side effects compared to traditional medicine. The metal NPs interaction with living cells (animal and plant) showed many ways to develop therapeutic models with the NPs. Despite all of the advancements that science has achieved, there is still a need to find out their performance for long-term use to solve modern challenges. In this regard, the present documentation reviews some potential metals, including silver (Ag), gold (Au), zinc (Zn), copper (Cu), iron (Fe), and nickel (Ni) NPs, as therapeutic agents in various areas such as anticancer, antimicrobial, antidiabetic, and applicable for the treatment of many other diseases. Depending on the outstanding ongoing research and practical trials, metal-based NPs can be considered the hope of prospective modern therapeutic areas.
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