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Inorganics
Special Issues
Evaluation of the Potential Biological Activity of Metallo-Drugs
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Evaluation of the Potential Biological Activity of Metallo-Drugs

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1582

Special Issue Editors

Dr. Snežana Jovanović-Stević

E-Mail Website
Guest Editor
University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, 34000 Kragujevac, Serbia
Interests: transition metal complexes; kinetics; biomolecules; interactions
Special Issues, Collections and Topics in MDPI journals
Dr. Jovana V. Bogojeski

E-Mail Website
Guest Editor
Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia
Interests: coordination chemistry; kinetics and mechanism; biomolecules; interactions

Special Issue Information

Dear Colleagues,

Cancer is the second leading cause of death after cardiovascular diseases. The use of transition metal complexes as chemotherapeutics has been well established. Until now, cisplatin, a platinum(II) complex which is an indispensable part in the therapy of various types of tumors, has demonstrated most success. However, serious side effects and drug resistance during its application limit the clinical use of cisplatin, leading many scientists to design new platinum complexes that are structurally similar to cisplatin. Some of them have shown significant potential anticancer activity, even better than cisplatin. Today, research is directed toward complexes of ions of other transition metals such as palladium(II), gold(III), ruthenium(II), osmium(II), rhodium(III), copper(II), etc. It is well known that metal-based compounds exert anticancer activity via interaction with DNA molecules. On the other hand, interaction of these compounds with some sulfur-containing bio-molecules can cause side effects. In order to evaluate potential antitumor activity, selectivity of action and toxicity of metallo-drugs, it is necessary to examine the kinetics and mechanism of their reactions with DNA segments, as well as with DNA molecules themselves. Further, the binding of anticancer agents to proteins is an important factor in the pharmacological response of drugs. Serum albumins (SAs) are the most abundant proteins in plasma and have a crucial role in the transport of many drugs to the target sites. Thus, the study of interaction between transition metal complexes and serum albumin proteins can provide useful information about the therapeutic efficiency of the drug. In this Special Issue, we wish to publish the latest developments in the design of transition metal-based compounds and their potential clinical applications through original research articles and short critical reviews.

Dr. Snežana Jovanović-Stević
Dr. Jovana V. Bogojeski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis
  • metal-based drugs
  • DNA/serum albumin proteins
  • small molecules
  • interactions

Published Papers (2 papers)

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Research

23 pages, 6782 KiB  
Article
Synthesis of Cobalt(III) Complexes Derived from Pyridoxal: Structural Cleavage Evaluations and In Silico Calculations for Biological Targets
by Liniquer André Fontana, Francisco Mainardi Martins, Josiéli Demetrio Siqueira, Carlos Serpa, Otávio Augusto Chaves and Davi Fernando Back
Inorganics 2024, 12(6), 171; https://doi.org/10.3390/inorganics12060171 - 18 Jun 2024
Viewed by 619
Abstract
This study sought to investigate the synthesis of eight complexes constituted by a cobalt(III) (CoIII) metallic center coordinated to two units of iminic ligands LnC (n = 1–4, L1C–L4C), which are derivatives of pyridoxal hydrochloride and anilines with [...] Read more.
This study sought to investigate the synthesis of eight complexes constituted by a cobalt(III) (CoIII) metallic center coordinated to two units of iminic ligands LnC (n = 1–4, L1C–L4C), which are derivatives of pyridoxal hydrochloride and anilines with thioether function containing one to four carbons. Depending on the source of the cobalt ion and the addition (or not) of a non-coordinating counterion, complexes with distinct structures may form, being categorized into two series: [CoIII(LnC)(L0C)] (n = 1–4, C1’–C4’) with a LnC ligand and a ligand that has a thiolate function which cleaves the C-S(thioether) bond (L0C) and [CoIII(LnC)2]PF6 (n = 1–4, C1–C4) with two similar units of the same LnC ligand. The occurrence (or not) of cleavage in the eight complexes was observed by elucidating the solid-state structures by single crystal X-ray diffraction. This exciting method allows the synthesis of CoIII complexes without cleaving the C-S bonds from the ligands, thereby not requiring an inert atmosphere in the reaction systems. The synthesized complexes were evaluated by in silico calculations on viable biological targets such as deoxyribonucleic acid, superoxide dismutase enzyme, human serum albumin, and the structural spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with the receptor binding domain (RBD) in both up and down conformations without and in complex with the cellular receptor angiotensin-converting enzyme 2 (ACE2). Overall, in silico results suggested that all the inorganic complexes under study are potential anticancer/antiviral agents; however, C4 and C4’ are the best candidates for future in vitro assays. Full article
(This article belongs to the Special Issue Evaluation of the Potential Biological Activity of Metallo-Drugs)
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12 pages, 2507 KiB  
Article
Investigating the Anticancer Properties of Novel Functionalized Platinum(II)–Terpyridine Complexes
by Roberta Panebianco, Maurizio Viale, Valentina Giglio and Graziella Vecchio
Inorganics 2024, 12(6), 167; https://doi.org/10.3390/inorganics12060167 - 15 Jun 2024
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Abstract
Novel platinum(II) complexes of 4′-substituted terpyridine ligands were synthesized and characterized. Each complex had a different biomolecule (amine, glucose, biotin and hyaluronic acid) as a targeting motif, potentially improving therapeutic outcomes. We demonstrated that complexes can self-assemble in water into about 150 nm [...] Read more.
Novel platinum(II) complexes of 4′-substituted terpyridine ligands were synthesized and characterized. Each complex had a different biomolecule (amine, glucose, biotin and hyaluronic acid) as a targeting motif, potentially improving therapeutic outcomes. We demonstrated that complexes can self-assemble in water into about 150 nm nanoparticles. Moreover, the complexes were assayed in vitro toward a panel of human cancer cell lines (ovarian adenocarcinoma A2780, lung cancer A549, breast adenocarcinoma MDA-MB-231, neuroblastoma SHSY5Y) to explore the impact of the pendant moiety on the terpyridine toxicity. The platinum complex of terpyridine amine derivative, [Pt(TpyNH2)Cl]Cl, showed the best antiproliferative effect, which was higher than cisplatin and [Pt(Tpy)Cl]Cl. Selective in vitro antiproliferative activity was achieved in A549 cancer cells with the Pt–HAtpy complex. These findings underline the potential of these novel platinum(II) complexes in cancer therapy and highlight the importance of tailored molecular design for achieving enhanced therapeutic effects. Full article
(This article belongs to the Special Issue Evaluation of the Potential Biological Activity of Metallo-Drugs)
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