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Dentistry Journal
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Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition
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Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Oral Hygiene, Periodontology and Peri-implant Diseases".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1838

Special Issue Editors

Dr. Federica Di Spirito

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, 84126 Salerno, Italy
Interests: oral medicine and interconnected systemic disorders; oral microbiome, dysbiosis and interconnected systemic disorders; periodontology and implantology; applied technologies (disease prevention, teledentistry)
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Pia Di Palo

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy
Interests: implant dentistry; periodontology; oral surgery; oral medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a pleasure to invite you to submit manuscripts to the forthcoming Special Issue “Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition” that will be published in Dentistry Journal.

Periodontal and peri-implant diseases constitute an important public health problem, most often under-acknowledged and implicated with general health, oral health-related quality of life and socioeconomic burden, thus enhancing the prevention of periodontitis and peri-implantitis onset and progression should be considered crucial. Moreover, due to the interconnections between periodontal, peri-implant and general health status, principally relying on inflammatory response, periodontal immune-microbiome balance and neurobiological and genetic factors, subjects considered high risk for periodontitis and peri-implantitis development, as well as periodontal patients more prone to the onset or worsening of systemic disorders, should be regarded with caution in multi-disciplinary settings, improving interprofessional communication and collaboration.

Original studies, from basic to clinical research, as well as reviews, case series, case reports and short communications, that provide deeper insights into the etiopathogenesis, the putative interconnections with systemic diseases and neoplasms of such complex disorders and the possible mechanisms underlying aggressive, recurrent and refractory cases, potentially paving the way for innovative primary prevention strategies and therapeutic approaches in regards to more comprehensive and integrated management of periodontal and peri-implant diseases, with high-quality precision on a large scale and with personalized periodontal care for high-risk subjects, will be welcome.

Dr. Federica Di Spirito
Dr. Maria Pia Di Palo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal health
  • periodontal tissues
  • periodontal disease
  • gingivitis
  • periodontitis
  • peri-implant health
  • peri-implant tissues
  • peri-implant disease
  • peri-implantitis
  • peri-implant mucositis
  • periodontal treatment
  • periodontal care
  • periodontitis management
  • periodontitis management
  • periodontitis prevention
  • peri-implantitis prevention
  • microbiome
  • periodontal manifestations of systemic disease
  • tissue regeneration
  • bone regeneration
  • interdisciplinary approach

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Related Special Issue

Published Papers (4 papers)

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Research

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13 pages, 1050 KiB  
Article
The Correlations Between Diabetes Mellitus and Oro-Maxillofacial Disorders: A Statistical Perspective
by Ionut Catalin Botezatu, Mihaela Salceanu, Ana Emanuela Botez, Cristina Daniela Dimitriu, Oana Elena Ciurcanu, Claudiu Topoliceanu, Elena-Carmen Cotrutz and Maria-Alexandra Martu
Dent. J. 2025, 13(8), 373; https://doi.org/10.3390/dj13080373 - 18 Aug 2025
Viewed by 187
Abstract
Background/Objectives: The goal of this research was to determine the prevalence and distribution of the oro-maxillofacial pathologies in patients with diabetes mellitus and to determine the correlation between diabetes mellitus and oro-maxillofacial disorders. Methods: The retrospective study group consisted of 6868 patients [...] Read more.
Background/Objectives: The goal of this research was to determine the prevalence and distribution of the oro-maxillofacial pathologies in patients with diabetes mellitus and to determine the correlation between diabetes mellitus and oro-maxillofacial disorders. Methods: The retrospective study group consisted of 6868 patients (mean age 49.84 ± 22.79 years) admitted in Oral and Maxillofacial Surgery Department between 2018 and 2024. Qualitative data were analyzed by Chi-square (χ2) test. Odds Ratio (OR) and Relative Risk (RR) were measured for each oro-maxillofacial pathology. Quantitative data were analyzed by Student’s T-test. Results: Among patients with diabetes mellitus (DM), the estimated risk of malignant tumors was 5.29 times higher (RR = 5.29; p = 0.001) compared to the non-DM group, with 15.0% of diabetic patients affected, versus 1.4% in the non-diabetic group. The probability of periodontal disease in diabetic patients was 4.66 times higher (RR = 4.66; p = 0.001), affecting 5.5% of the DM group, compared to only 0.6% in the non-DM group. Diabetic patients had a likelihood 3.53 times higher (RR = 3.53; p = 0.001) of developing apical periodontitis, with 5.3% of the DM group affected, in contrast to 1.0% of the non-DM group. The presence of root remnants was 1.43 times more likely (RR = 1.43; p = 0.001) in diabetic patients, with 9.0% of the DM group affected, compared to 6.1% in the non-DM group. Conclusions: The strong correlation between diabetes and oral pathologies, particularly malignancies and periodontal disease, underscores the need for early screening, preventive care, and targeted management strategies for diabetic patients. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition)
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Review

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18 pages, 3393 KiB  
Review
The 2018 Classification of Periodontitis: Challenges from Clinical Perspective
by Marek Chmielewski, Andrea Pilloni, Alessandro Cuozzo, Giuseppe D’Albis, Gerarda D’Elia, Piero Papi and Lorenzo Marini
Dent. J. 2025, 13(8), 361; https://doi.org/10.3390/dj13080361 - 8 Aug 2025
Viewed by 486
Abstract
Objectives: The objective of this narrative review was to evaluate the clinical challenges encountered in the application of the 2018 AAP/EFP Classification of Periodontitis. Methods: Electronic and manual searches were conducted to identify studies reporting diagnostic accuracy and inter- and intra-examiner [...] Read more.
Objectives: The objective of this narrative review was to evaluate the clinical challenges encountered in the application of the 2018 AAP/EFP Classification of Periodontitis. Methods: Electronic and manual searches were conducted to identify studies reporting diagnostic accuracy and inter- and intra-examiner agreement when using the 2018 Classification, both with and without the aid of implementation tools. Results: Eleven studies were included, encompassing a total of 459 clinical cases. Overall, 852 examiners participated, with 31 gold-standard examiners providing the reference diagnoses. General dentists often exhibited lower diagnostic accuracy and consistency compared to students and periodontal experts. Diagnostic challenges were observed in staging, particularly distinguishing between Stage III/IV and gingivitis/Stage I. Grading reliability was reduced in the absence of longitudinal data and high-level modifying factors. This review also explored difficulties in reporting ‘hopeless teeth’ and assigning the extent of periodontitis. Education, training, and implementation tools substantially improved diagnostic accuracy and consistency, increasing the agreement with reference diagnosis and strengthening inter- and intra-examiner agreement. Conclusions: The application of the 2018 Classification showed notable variability in diagnostic accuracy and inter- and intra-examiner agreement. Improving clinician experience and training and incorporating diagnostic aids and emerging AI technologies has the potential to enhance diagnostic accuracy and consistency, which are essential for precisely estimating periodontitis prevalence, interpreting research findings, and determining prognosis and treatment needs. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition)
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14 pages, 520 KiB  
Review
Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review
by Sarmistha Saha, Nadezhda Sachivkina, Ekaterina Lenchenko, Olga Pilshchikova and Alexandr Muraev
Dent. J. 2025, 13(7), 314; https://doi.org/10.3390/dj13070314 - 11 Jul 2025
Viewed by 410
Abstract
Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing [...] Read more.
Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing the relationship between inflammation and oxidative stress, making it vital for understanding this disease. Nrf2 interacts with key redox-sensitive inflammatory pathways, playing a vital role in the development of periodontitis. Acknowledging these dynamics underscores the importance of proactively addressing the complex aspects of periodontal disease. This review emphasizes its intricate interactions with redox-sensitive transcription factors vital for sustaining the self-perpetuating inflammatory processes underlying the disease. Additionally, it explores promising therapeutic strategies aimed at Nrf2 activation and encourages more effective management of PD. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition)
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Other

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15 pages, 3700 KiB  
Case Report
Electrolytic Cleaning as Part of Surgical Reconstructive Peri-Implantitis Treatment: A Case Series
by Jarno Hakkers, Henny J. A. Meijer, Yvonne C. M. de Waal and Gerry M. Raghoebar
Dent. J. 2025, 13(6), 237; https://doi.org/10.3390/dj13060237 - 26 May 2025
Viewed by 486
Abstract
Background/Objectives: The aim of this study was to assess the workflow and evaluate the clinical, radiographic and patient-reported outcome measures of surgical reconstructive peri-implantitis treatment aided with an electrolytic cleaning device. Methods: This case series describes three patients that presented with peri-implantitis surrounding [...] Read more.
Background/Objectives: The aim of this study was to assess the workflow and evaluate the clinical, radiographic and patient-reported outcome measures of surgical reconstructive peri-implantitis treatment aided with an electrolytic cleaning device. Methods: This case series describes three patients that presented with peri-implantitis surrounding an implant in the anterior maxilla, eligible for surgical reconstructive peri-implantitis treatment. The implant crown was removed, and the patients were surgically treated during which an electrolytic cleaning device was used to clean the implant surface. Thereafter, the implant site was augmented using locally harvested bone and a bovine bone substitute. After 6 months of submerged healing, the implant crown was replaced. Follow-up visits were performed 3 and 6 months after restoration placement. Clinical and radiographical parameters, as well as Patient-Reported Outcome Measures (PROMs) and Pink Esthetic Scores (PESs) were collected. Results: The data collected indicate a positive trend with regard to peri-implant pocket depth, bleeding and suppuration scores, as well as the peri-implant marginal bone level for the evaluated cases six months postoperatively. PROMs with regard to pain experience varied between 4.5 and 5.9 on the Visual Analogue Scale (VAS). After 12 months, the PES increased in two cases and decreased in one case. Conclusions: This case series provides a comprehensive overview of the surgical reconstructive peri-implantitis treatment using an electrolytic cleaning device, highlighting promising results with regard to the aforementioned parameters. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management: 2nd Edition)
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