Microbiota in Human Disease

A special issue of Diseases (ISSN 2079-9721).

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1842

Special Issue Editors


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Guest Editor
Department of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: clinical and cellular immunology; microbiota and the immune system: crosstalk in health and diseases
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Guest Editor
Department of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: internal medicine; microbiota and the immune system

Special Issue Information

Dear Colleagues,

In recent years, there has been a growing interest in the research on the interplay between microbiota and hosts in the onset of several diseases. Some diseases have been associated with the disruption of the equilibrium in the gut microbiota, such as cancer and inflammatory diseases, but others could be related to gut microbial dysbiosis in their onset and progression. The aim of this Special Issue is to comprehensive report the state of the art of the link between microbiota and several infectious as well as communicable diseases. We accept reviews, original articles, and meta-analyses that describe the complex crosstalk between microbiota and hosts in the development and progression of diseases, including the role of nutrition, physical exercise, immune disorders, and pollutants.

Dr. Rossella Cianci
Dr. Pierluigi Rio
Guest Editors

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Keywords

  • microbiota
  • immune system
  • adaptive and innate immunity
  • infectious diseases
  • non-communicable diseases

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Published Papers (1 paper)

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Review

23 pages, 1106 KiB  
Review
Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases
by Laura Di Renzo, Paola Gualtieri, Giulia Frank, Rossella Cianci, Mario Caldarelli, Giulia Leggeri, Glauco Raffaelli, Erica Pizzocaro, Michela Cirillo and Antonino De Lorenzo
Diseases 2024, 12(8), 176; https://doi.org/10.3390/diseases12080176 - 2 Aug 2024
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Abstract
The exposome encompasses all endogenous and exogenous exposure individuals encounter throughout their lives, including biological, chemical, physical, psychological, relational, and socioeconomic factors. It examines the duration and intensity of these types of exposure and their complex interactions over time. This interdisciplinary approach involves [...] Read more.
The exposome encompasses all endogenous and exogenous exposure individuals encounter throughout their lives, including biological, chemical, physical, psychological, relational, and socioeconomic factors. It examines the duration and intensity of these types of exposure and their complex interactions over time. This interdisciplinary approach involves various scientific disciplines, particularly toxicology, to understand the long-term effects of toxic exposure on health. Factors like air pollution, racial background, and socioeconomic status significantly contribute to diseases such as metabolic, cardiovascular, neurodegenerative diseases, infertility, and cancer. Advanced analytical methods measure contaminants in biofluids, food, air, water, and soil, but often overlook the cumulative risk of multiple chemicals. An exposome analysis necessitates sophisticated tools and methodologies to understand health interactions and integrate findings into precision medicine for better disease diagnosis and treatment. Chronic exposure to environmental and biological stimuli can lead to persistent low-grade inflammation, which is a key factor in chronic non-communicable diseases (NCDs), such as obesity, cardiometabolic disorders, cancer, respiratory diseases, autoimmune conditions, and depression. These NCDs are influenced by smoking, unhealthy diets, physical inactivity, and alcohol abuse, all shaped by genetic, environmental, and social factors. Dietary patterns, especially ultra-processed foods, can exacerbate inflammation and alter gut microbiota. This study investigates the exposome’s role in the prevention, development, and progression of NCDs, focusing on endogenous and exogenous factors. Full article
(This article belongs to the Special Issue Microbiota in Human Disease)
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