Microalgae: Biofactory for Valuable Products

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Industrial Fermentation".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2269

Special Issue Editor

Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China
Interests: high-density cultivation of microalgae; metabolic engineering of microalgae; microalgal biorefining
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the face of global challenges such as climate change and increasing demand for sustainable and nutritious resources, the exploration of alternative sources has become imperative. Microalgae, capable of converting sunlight and carbon dioxide into biomass, have garnered significant attention for addressing these pressing issues. These tiny organisms are rich sources of lipids, proteins, carbohydrates, pigments, and bioactive compounds, which have applications in food and feed in addition to the pharmaceutical, nutraceutical, and cosmetics industries.

Microalgae can be cultivated in various environments, including freshwater, seawater, and industrial wastewater, minimizing the competition for arable land and freshwater resources. Their fast growth rates and high biomass productivity further enhance their potential as a sustainable bioresource. Microalgae possess the unique ability to synthesize and accumulate high levels of polyunsaturated fatty acids (PUFAs), including omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as omega-6 fatty acids, such as gamma-linolenic acid (GLA). These PUFAs are known for their numerous health benefits, including anti-inflammatory properties, improving cognitive function, and cardiovascular health promotion. Pigments from microalgae are promising ecofriendly colorants, nutraceuticals, and antioxidants. Moreover, several secondary metabolites, such as polysaccharides and peptides, possess therapeutic potential that can be harnessed for the development of drugs, nutraceuticals, and functional foods.

This Special Issue is for the purpose of publishing both recent innovative research results as well as review papers on valuable products from microalgae biofactory through various cultivation modes, bioreactors, cultivation strategies, and downstream processes. Strain improvement, metabolic engineering, and bioreactor design are of great significance. The delivery system and bioactivity of microalgal products are also of interest.

Dr. Han Sun
Guest Editor

Manuscript Submission Information

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Keywords

  • pigment
  • PUFAs
  • cultivation strategy
  • strain improvement
  • metabolic engineering
  • bioreactor design
  • delivery system
  • bioactivity

Published Papers (1 paper)

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Research

15 pages, 3481 KiB  
Article
Light Induction of Seed Culture Accelerates Lutein Accumulation in Heterotrophic Fermentation of Chlorella protothecoides CS-41
by Yunlei Fu, Lanbo Yi, Shufang Yang, Xue Lu, Bin Liu, Feng Chen, Junchao Huang, Kawing Cheng, Han Sun and Xiaolei Wu
Fermentation 2023, 9(8), 768; https://doi.org/10.3390/fermentation9080768 - 18 Aug 2023
Cited by 2 | Viewed by 1453
Abstract
Microalgae are recognized as a promising and valuable source of lutein. However, the current two-stage method for lutein production has drawbacks, such as complex operations and a long cultivation time. Additionally, utilizing heterotrophic fermentation to cultivate microalgae for lutein production leads to low [...] Read more.
Microalgae are recognized as a promising and valuable source of lutein. However, the current two-stage method for lutein production has drawbacks, such as complex operations and a long cultivation time. Additionally, utilizing heterotrophic fermentation to cultivate microalgae for lutein production leads to low lutein content due to the absence of light. In this study, we proposed a novel cultivation method that involves light induction of the seed culture to enhance lutein production during the heterotrophic cultivation phase of Chlorella protothecoides CS-41. To gain comprehensive insights into the underlying mechanisms of this method, we conducted qualitative and quantitative analyses of specific metabolites related to central carbon metabolism. The results revealed that low-light induction of seeds exhibited higher carbon efficiency compared to cells continuously subjected to heterotrophic cultivation, which may explain the observed increase in biomass and lutein content in cultures. Cultures after low-light induction of seed exhibited significantly higher lutein content (2.71 mg/g), yield (66.49 mg/L) and productivity (8.59 mg/L/d) compared to those consistently cultivated under heterotrophic conditions (2.37 mg/g, 37.45 mg/L, 4.68 mg/L/d). This cultivation strategy effectively enhances lutein yields, reduces production costs and holds the potential for broader application in other algal species for pigment production. Full article
(This article belongs to the Special Issue Microalgae: Biofactory for Valuable Products)
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