Immunology, Environment, and Nutrition of Aquatic Animals

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Nutrition and Feeding".

Deadline for manuscript submissions: 10 September 2026 | Viewed by 1068

Special Issue Editor

Special Issue Information

Dear Colleagues,

The health and resilience of aquatic animals are governed by the critical triad of immunology, environment, and nutrition. These three elements are deeply intertwined, dictating an animal’s ability to survive, grow, and reproduce in the aquatic realm.

An aquatic animal’s immune system is its primary defense against pathogens. Unlike terrestrial animals, they rely heavily on innate immunity—physical barriers like skin and mucus, as well as cellular and humoral responses—as their first line of defense. The adaptive immune system, while present, is often slower to respond.

The environment directly challenges this immune competence. Fluctuations in key water quality parameters—such as temperature, dissolved oxygen, salinity, and pollutants—act as stressors. Chronic stress elevates cortisol levels, which can suppress immune function, increasing susceptibility to disease. This is where nutrition plays a pivotal role. A balanced diet provides the essential building blocks for immune cells and molecules. Key nutrients like vitamins (A, C, and E), minerals (zinc and selenium), and specific fatty acids (omega-3s) are crucial for maintaining robust immune responses. Optimal nutrition can help mitigate the immunosuppressive effects of environmental stress.

In conclusion, successful aquatic animal management, whether in aquaculture or conservation, requires an integrated approach. Understanding how environmental conditions influence immune function and how nutritional strategies can be optimized to bolster defense mechanisms is essential for ensuring aquatic animal health and sustainability.

Dr. Quanquan Cao
Guest Editor

Manuscript Submission Information

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Keywords

  • immunology
  • environment
  • nutrition
  • aquatic animals
  • signal regulation

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Published Papers (1 paper)

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Review

20 pages, 1731 KB  
Review
Cottonseed Protein as an Alternative Feed Ingredient for Fish: Nutritional Metabolism and Physiological Implications
by Yue Hu, Yang Xie, Youdi Tang, Jiarui Liu, Esau Mbokane, Rana Al-Sayed Dawood, Jie Luo, Debing Li and Quanquan Cao
Fishes 2026, 11(1), 10; https://doi.org/10.3390/fishes11010010 - 25 Dec 2025
Viewed by 831
Abstract
Against the backdrop of the continuous expansion of the global aquaculture industry and the growing demand for high-quality feed protein, the development of sustainable alternative protein sources to fishmeal is crucial. Cottonseed protein, particularly cottonseed protein concentrate, has emerged as a highly promising [...] Read more.
Against the backdrop of the continuous expansion of the global aquaculture industry and the growing demand for high-quality feed protein, the development of sustainable alternative protein sources to fishmeal is crucial. Cottonseed protein, particularly cottonseed protein concentrate, has emerged as a highly promising plant-based alternative raw material due to its high protein content and cost advantages. This review systematically evaluates the application effects, challenges, and mechanisms of action of cottonseed protein in fish feed. Core analysis indicates that the primary limiting factor of cottonseed protein is the antinutritional factor free gossypol. High-level replacement (typically >30%) of fishmeal can inhibit fish growth, reduce protein deposition, and impair intestinal health. These adverse effects are closely associated with the downregulation of the hepatic mTOR signaling pathway—a central regulator of protein synthesis and cell growth—shifting the organism’s energy allocation from growth to stress adaptation. Furthermore, the unique fatty acid profile of cottonseed protein may exacerbate energy metabolism imbalance. To overcome gossypol toxicity, physical, chemical, and biological detoxification technologies have been widely applied. Among these, biological methods (such as Bacillus subtilis fermentation and CotA laccase-catalyzed degradation) are particularly outstanding, not only efficiently removing gossypol (removal rate > 90%) but also degrading macromolecular proteins into more digestible and absorbable small peptides and amino acids, significantly enhancing the nutritional value of cottonseed protein. Although the application prospects for cottonseed protein are broad, gaps remain in current research, particularly concerning the deeper metabolic pathways, nutrient utilization efficiency, and long-term impacts on metabolic homeostasis of detoxified cottonseed protein in fish. Future research needs to employ molecular nutrition and multi-omics technologies to elucidate its metabolic mechanisms and optimize detoxification processes and precision feeding strategies. Glandless cottonseed varieties, which fundamentally address the gossypol issue, are considered the most transformative development direction. Through continuous technological innovation, cottonseed protein is expected to become a core feed protein ingredient promoting the sustainable development of the global aquaculture industry. Full article
(This article belongs to the Special Issue Immunology, Environment, and Nutrition of Aquatic Animals)
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