Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.8
5.2
Journals
Foods
Special Issues
Development of Functional Foods and Nutraceuticals for Gut Health
share announcement

Development of Functional Foods and Nutraceuticals for Gut Health

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3256

Special Issue Editor

Dr. Meram Chalamaiah

E-Mail Website
Guest Editor
Department of Agricultural, Food, and Nutritional Science, Faculty of Agricultural, University of Alberta, Edmonton, AB, Canada
Interests: nutrition; nutraceuticals; antioxidant activity; food chemistry; nutrition assessment; bioactivity; biological activities; functional food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Functional foods/nutraceuticals are foods/components of foods that promote human health in addition to normal nutritional value. Recently, functional foods and nutraceuticals have attracted great attention from scientists and consumers due to their diverse health-promoting properties with fewer or no side effects. The gut plays an important role in digestion and immune defense. The microbiome of the gut and intestinal barrier are the two important factors that significantly affect gut health. Functional foods/nutraceuticals with various biological properties could potentially improve gut health through several molecular mechanisms. Therefore, development of functional foods/nutraceuticals based on prebiotics, probiotics, proteins, peptides, polysaccharides, lipids, polyphenols, vitamins, minerals, etc. is important in order to promote gut health and protect the body from invading pathogens.

Dr. Chalamaiah Meram
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut health
  • functional foods
  • nutraceuticals
  • bioactive compounds
  • food chemistry

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 3989 KiB  
Article
Role of Short Chain Fatty Acids to Counteract Inflammatory Stress and Mucus Production in Human Intestinal HT29-MTX-E12 Cells
by Carlotta Giromini, Antonella Baldi, Raffaella Rebucci, Davide Lanzoni, Martina Policardi, Tamil selvi Sundaram and Stig Purup
Foods 2022, 11(13), 1983; https://doi.org/10.3390/foods11131983 - 5 Jul 2022
Cited by 8 | Viewed by 2552
Abstract
Short chain fatty acids (SCFAs), especially butyrate (BUT), are known to promote intestinal health, but their role in the protection of intestinal barrier integrity is poorly characterized. The aim of the study was to set up an in vitro model of human colon [...] Read more.
Short chain fatty acids (SCFAs), especially butyrate (BUT), are known to promote intestinal health, but their role in the protection of intestinal barrier integrity is poorly characterized. The aim of the study was to set up an in vitro model of human colon epithelium using HT29-MTX-E12 cells to delineate the potential role of SCFAs under stress conditions. Accordingly, the HT29-MTX-E12 cells were differentiated for 42 days and subsequently exposed to dextran sulphate sodium (DSS). Further, the effects of BUT or its mixture with acetate and propionate (SCFAs-MIX) were tested to study proliferation, epithelial integrity and mucus production. The results showed that the concentration of 10% DSS for 24 h decreased the TEER about 50% compared to the control in HT29-MTX-E12 cells. The pre-treatment on HT29-MTX-E12 cells with BUT or SCFAs-MIX at specific concentrations significantly (p < 0.05) reduced the DSS-induced damage on epithelial cell integrity and permeability. Further, the treatment with specific concentrations of BUT and SCFAs-MIX for 24 h significantly promoted ZO-1, MUC2 and MUC5AC mRNA expression (p < 0.005). The present study demonstrated the suitability of HT29-MTX-E12 cells treated with DSS as an in vitro stress model of inflammatory bowel disease, which enabled us to understand the effect of bioactive SCFAs on the intestinal barrier. Full article
(This article belongs to the Special Issue Development of Functional Foods and Nutraceuticals for Gut Health)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop