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Innovative Functional Foods for Chronic Disease Prevention

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Plant Foods".

Deadline for manuscript submissions: closed (10 May 2026) | Viewed by 976

Special Issue Editors


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Guest Editor
1. Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
2. Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea
Interests: plant carbohydrates; dietary fibers; glycemic response; obesity; aging and metabolic diseases

E-Mail Website
Guest Editor
1. Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
2. Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea
Interests: plant-derived nutrients; ketogenic diet; oxidative stress; glycemic response and metabolic diseases

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the upcoming Special Issue entitled ‘Innovative Functional Foods for Chronic Disease Prevention in Foods. This Special Issue aims to highlight cutting-edge research on plant-based foods and plant-derived carbohydrates, focusing on their role in modulating glycemic response and preventing chronic metabolic diseases.

Glycemic response is crucial for maintaining postprandial blood glucose homeostasis. While early studies established that total carbohydrate intake significantly impacts this regulation, emerging research emphasizes the complex relationship between components of plant foods, including micronutrients, dietary fibers, resistant starches, and bioactive compounds and their combined impact on glycemic index (GI) and glycemic load (GL).

However, it remains unclear how plant-derived sugars and other phytoconstituents influence glycemic response and insulin signaling pathways, both of which are essential for glucose metabolism and long-term metabolic health. High-glycemic diets have been associated with various pathological conditions, including cardiovascular diseases, neurodegenerative disorders, inflammation, obesity, and cancer. Therefore, there is an increasing need to identify and develop novel plant-based foods and bioactive compounds that promote low glycemic response and contribute to chronic disease prevention.

This Special Issue welcomes original research articles, reviews, and short communications that address, but are not limited, to the following topics:

  • Mechanistic studies on plant-based sugars, carbohydrates, and dietary fibers that influence glycemic index and glycemic load
  • Development of functional foods from fruits, vegetables, grains, and legumes with low glycemic potential
  • Innovative technologies for measuring, predicting, and modulating glycemic response and insulin sensitivity
  • Interactions between the gut microbiome and plant-derived carbohydrates and their role in chronic disease prevention
  • Nutritional interventions and clinical trials assessing the effectiveness of functional foods in managing glycemic control
  • Advances in food processing, bioavailability, and nutrient delivery systems that optimize glycemic outcomes
  • Epidemiological and population-based studies linking plant-based diets with reduced metabolic and chronic disease risks.

All manuscripts will undergo a rigorous peer review process to ensure high scientific quality and relevance to the field. Submissions should comply with the journal’s author guidelines and ethical standards.

Dr. Manish Singh
Prof. Dr. Sung Soo Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant-based sugar and carbohydrates
  • fruit, vegetable and grain and dietary fiber
  • glycemic response and insulin signaling
  • gut microbiota and impact on glucose metabolism
  • glucose intolerance, insulin resistance and obesity

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Published Papers (1 paper)

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Research

19 pages, 1152 KB  
Article
Integrating Phytochemical Bioactivity and Glycemic Risk to Evaluate Fruits for Type 2 Diabetes Management: A Korean Market Perspective
by Jyotsna S. Ranbhise, Manish Kumar Singh, Hyeong Rok Yun, Sunhee Han, Sung Soo Kim and Insug Kang
Foods 2026, 15(5), 797; https://doi.org/10.3390/foods15050797 - 24 Feb 2026
Viewed by 552
Abstract
Background: Dietary guidance for type 2 diabetes mellitus (T2DM) frequently discourages fruit consumption due to intrinsic sugars, despite extensive evidence supporting the anti-diabetic properties of fruit-derived polyphenols. This reductionist, carbohydrate-only model inadequately reflects the complex bioactive matrices of whole fruits. Objective: To develop [...] Read more.
Background: Dietary guidance for type 2 diabetes mellitus (T2DM) frequently discourages fruit consumption due to intrinsic sugars, despite extensive evidence supporting the anti-diabetic properties of fruit-derived polyphenols. This reductionist, carbohydrate-only model inadequately reflects the complex bioactive matrices of whole fruits. Objective: To develop an integrated analytical framework that quantitatively balances the predicted anti-diabetic bioactivity of fruit polyphenols against their glycemic burden, and to apply this model to fruits commonly consumed in the Korean market. Methods: Nutritional and phytochemical composition data for five fruits sourced from Korea and India were obtained from national food databases to ensure broader phytochemical diversity. Six representative polyphenols were selected based on abundance and reported significance. Molecular docking was conducted against α-glucosidase and peroxisome proliferator-activated receptor gamma (PPAR-γ) to estimate target-specific affinity, and a “Total Predicted Anti-Diabetic Score” (TPAS) was computed by weighting docking potency by compound concentration. A risk–benefit matrix integrating TPAS and sugar content was applied to classify fruits, followed by a cultivar-level comparison of major grape varieties. Results: Hesperidin exhibited the strongest predicted PPAR-γ binding (−9.3 kcal/mol). Among whole fruits, grapes and oranges showed the highest TPAS (593.19 and 448.77, respectively), placing them in the “redemptive choice” category (high benefit/high glycemic risk). Comparative cultivar analysis identified the Campbell Early grape as the most advantageous option, with a Holistic Value Score (HVS) of 9.5, notably higher than Shine Muscat (3.9). Conclusions: This study presents a structured, computation-driven framework capable of integrating phytochemical potency and nutritional risk into a unified metric for dietary evaluation. Despite higher sugar content, fruits rich in potent polyphenols may confer substantial metabolic benefit when consumed judiciously. These findings challenge sugar-centric dietary models and provide an evidence-based tool for consumer-level guidance in T2DM dietary management. Full article
(This article belongs to the Special Issue Innovative Functional Foods for Chronic Disease Prevention)
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