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Flavonoids in Plant Foods: Extraction, Identification, Metabolism, Bioavailability and Health
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Flavonoids in Plant Foods: Extraction, Identification, Metabolism, Bioavailability and Health

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Plant Foods".

Deadline for manuscript submissions: 5 July 2026 | Viewed by 1276

Special Issue Editors

Prof. Dr. Norma Julieta Salazar-López

E-Mail Website
Guest Editor
Facultad de Medicina de Mexicali, Universidad Autónoma de Baja California, Dr. Humberto Torres Sanginés, Centro Cívico, Mexicali 21000, BCN, Mexico
Interests: bioactive compounds and health effects; alternative protein; valorization to underused food and byproducts; functional food; prebiotics, probiotics and paraprobiotics
Dr. Maribel Robles-Sánchez

E-Mail Website
Guest Editor
Departmento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Blvd. Luis Encinas y Rosales s/n, Col Centro, Hermosillo 83000, SO, Mexico
Interests: antioxidant; sorghum; phenolic compounds; fruit

Special Issue Information

Dear Colleagues,

Flavonoids are a group of bioactive compounds contained in plant foods with potential health benefits. The antioxidant, anti-inflammatory, anti-obesogenic and immunomodulatory activity they display are just some of the health benefits that have been identified through different experimental models. However, the diversity, metabolism and bioavailability of flavonoids, as well as the mechanisms by which they induce health benefits, are still being evaluated, so research in this area is relevant and necessary.

This Special Issue aims to receive contributions offering considerable advances in the field of flavonoids, specifically those that include developments in extraction, identification, metabolism, bioavailability and their effects on health. These investigations will contribute to identifying strategies to incorporate flavonoids in supplements, nutraceuticals and functional foods and thereby contribute to their benefits reaching the population, which may be otherwise limited because flavonoids are found in perishable plant foods.

We cordially invite fellow researchers in these fields to submit their contributions to this Special Issue.

Prof. Dr. Norma Julieta Salazar-López
Dr. Maribel Robles-Sánchez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • flavonoids
  • biological activities
  • metabolism
  • functional foods
  • nutraceuticals
  • bioavailability
  • absorption of flavonoids
  • digestive simulation
  • pharmacokinetics
  • green extraction techniques
  • sustainable extraction

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Published Papers (1 paper)

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Research

16 pages, 740 KB  
Article
A 100 mg/kg Dose of Naringenin as an Anti-Obesity Agent for Eight Weeks Exerts No Apparent Hepatotoxic or Nephrotoxic Effects in Wistar Rats
by Gabriela López-Almada, J. Abraham Domínguez-Avila, Gustavo A. González-Aguilar, Rosario Maribel Robles-Sánchez and Norma Julieta Salazar-López
Foods 2025, 14(23), 4083; https://doi.org/10.3390/foods14234083 - 28 Nov 2025
Viewed by 931
Abstract
Naringenin (NAR) is a naturally occurring flavanone characteristic of citrus fruits and other foods whose anti-obesity effects have been reported. As a dietary xenobiotic, it is metabolized and excreted mainly by the liver and kidneys, respectively. Since an organism does not normally consume [...] Read more.
Naringenin (NAR) is a naturally occurring flavanone characteristic of citrus fruits and other foods whose anti-obesity effects have been reported. As a dietary xenobiotic, it is metabolized and excreted mainly by the liver and kidneys, respectively. Since an organism does not normally consume pure phenolic compounds, there are concerns about its safety when administered as such. The present work reports an analysis on the safety of consuming NAR as an anti-obesity agent (100 mg/kg body weight) alongside a Western diet (WD) during an eight-week period, according to various serum biochemical markers of liver and kidney function in Wistar rats. Blood samples were analyzed to determine liver function, including enzyme activity (ALT, AST, GGT, and ALP), bilirubin, and albumin. Biochemical markers of kidney function were urea, blood urea nitrogen (BUN), creatinine, uric acid, and electrolytes. Results show that a 100 mg/kg oral dose of NAR for eight weeks exerted no apparent hepato- or nephrotoxicity, suggesting a suitable safety profile at said dose, since all variables analyzed remained within normal reference limits in NAR-treated animals. Urea, BUN, and ALP showed significant differences between the WD and the control group fed a basal diet (BD), although this was independent of NAR (p < 0.05, WD and WD + NAR vs. BD and BD + NAR), suggesting that diet played a role. The data support the previously reported hepatoprotective effects of NAR and suggest a favorable safety profile. Altogether, the findings indicate that pure NAR may be safe at the dose employed and during the analyzed time period, which further supports the need for clinical studies to validate its application in human consumers. Full article
(This article belongs to the Special Issue Flavonoids in Plant Foods: Extraction, Identification, Metabolism, Bioavailability and Health)
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