Advancements in Forensic Chemical Analysis and Related Techniques

A special issue of Forensic Sciences (ISSN 2673-6756).

Deadline for manuscript submissions: 20 May 2025 | Viewed by 382

Special Issue Editors


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Guest Editor
Department of Pharmacology and Toxicology, University of Houston-Downtown, One Main St Suite STB 332, Houston, TX 77022, USA
Interests: forensic chemistry; drug analysis; chemical analysis; chromatography; mass spectrometry, paint and ink analysis; paper and fiber analysis

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Guest Editor
U.R.I.To.N. Research Unit, UNIFI · Dipartimento NEUROFARBA, University of Florence, Florence, Italy
Interests: medicinal chemistry; drugs; toxicology; enzymes; X-ray crystallography
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Guest Editor
Department of Pharmacy, University “G. d’Annunzio” of Chieti and Pescara, Chieti, Italy
Interests: innovative (micro)extraction procedures; hyphenated instrument configurations; bioactive compounds; characterization; fingerprints; method validation; HPLC; mass spectrometry; biological matrices; chromatography; analytical chemistry; sample preparation; green analytical methodologies
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Special Issue Information

Dear Colleagues,

Forensic chemical analysis plays an important role in the criminal investigation process. However, the chemical analysis of forensic samples is challenging due to the complex nature of the sample matrix. In some situations, sample quantity can be very minimal, making the analysis very difficult. To provide meaningful scientific interpretations of the evidence collected, the analytic technique needs to be accurate and widely accepted in the scientific community. Analytical techniques need to be optimized based on the type of evidence, and they typically use the principles of chemistry, biology, and physics to reach meaningful conclusions about the identity of substances and their quantity.

Chromatographic drug separation and spectroscopic techniques are commonly employed in chemical analysis. New chemicals and modifications to existing drug molecules make the analysis of evidence difficult, especially in terms of identifying dangerous chemicals. Therefore, new chemical analysis methods and techniques are vital for forensic science and the criminal investigation process.

In this Special Issue, we invite scientific articles on the chemical analysis of forensic-related samples and substances or new techniques in this field. This may include, but are not limited to, the analysis of drugs, chemicals, paints, inks, paper, and explosives. Toxicological analyses and the development of DNA analytical techniques will also be considered.

Dr. Jacob Theruvathu
Dr. Fabrizio Carta
Dr. Marcello Locatelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Forensic Sciences is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • forensic chemistry
  • drug analysis
  • chemical analysis
  • paint and ink analysis
  • fiber and paper analysis
  • arson and explosives
  • chromatography
  • mass spectrometry

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Published Papers (1 paper)

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Research

13 pages, 2878 KiB  
Article
An Alternative Method to Measure Glucose and Lactic Acid as Biomarkers of the Postmortem Interval (PMI)
by Claudio Tersaruolo, Jesus Frias and Orla Howe
Forensic Sci. 2025, 5(2), 17; https://doi.org/10.3390/forensicsci5020017 - 21 Apr 2025
Abstract
Background: In forensic investigations, the postmortem interval (PMI) is still mainly determined using pathological analysis. There have been many scientific efforts to identify alternative methods of PMI determination, which may be applied to future forensic practices. Methods: Considering the ethical implications and the [...] Read more.
Background: In forensic investigations, the postmortem interval (PMI) is still mainly determined using pathological analysis. There have been many scientific efforts to identify alternative methods of PMI determination, which may be applied to future forensic practices. Methods: Considering the ethical implications and the availability of tissue samples for PMI experiments, we used human blood samples stored at three temperatures to mimic different environmental conditions, testing them over a period of 10 days post-sampling. These samples were biochemically tested for specific blood biomarkers, glucose (Glu) and lactic acid (Lac), to determine their potential as PMI biomarkers. Then, a mixed-effect mathematical model was applied to the data related to time- and temperature-dependent concentration changes of both biomarkers followed by additional computer-simulated models to refine the PMI estimates based on each of the biomarker concentration changes. Results: Herein, we present this alternative method of PMI estimation based on the biochemical testing of blood samples that could potentially be collected at a crime scene using biochemical blood biomarkers Glu and Lac, which are mathematically modelled and refined with time- and temperature concentration changes. Conclusions: While there is still much forensic science required to validate any alternative PMI methods, this study shows that there are other cross-disciplinary methods of PMI determination that warrant further exploration. Full article
(This article belongs to the Special Issue Advancements in Forensic Chemical Analysis and Related Techniques)
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