Recent Advances in Pharmaceutical and Biomedical Analysis

A special issue of Future Pharmacology (ISSN 2673-9879).

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3485

Special Issue Editor


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Guest Editor
Institute of Medical Sciences, College of Medical Sciences, University of Rzeszów, Rzeszów, Poland
Interests: liquid chromatography; mass spectrometry; biomedical and pharmaceutical analysis; sample preparation methods; drug development; clinical trials

Special Issue Information

Dear Colleagues,

Analytical techniques and methods are constantly being developed to improve the efficiency and quality of pharmaceutical and biomedical analysis. Development and validation of reliable analytical methods are important in the analysis of drugs, metabolites, biomolecules in biological samples, and drugs or related substances in pharmaceutical formulations. Progress in pharmaceutical and biomedical sciences is often dependent on the development of analytical methods. An important role is played here by the application of innovative approaches in analytical techniques such as liquid chromatography (LC), gas chromatography (GC), capillary electrophoresis (CE), and mass spectrometry (MS). This Special Issue will cover the interdisciplinary aspects of analysis in the pharmaceutical and biomedical sciences. We sincerely invite researchers to contribute high-quality original research or review articles.  Potential topics include, but are not limited to:

  • development of modern analytical methods
  • drug purity and stability studies
  • pharmacokinetics
  • therapeutic drug monitoring
  • characterization and detection of new therapeutics
  • metabolic studies
  • drug-related aspects of forensic toxicology
  • detection of illicit/recreational drugs use

Dr. Karol Wróblewski
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmaceutical analysis
  • biomedical analysis
  • separation methods
  • mass spectrometry
  • sample preparation
  • analytical method development
  • validation

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Published Papers (1 paper)

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Research

15 pages, 2529 KiB  
Article
Modulation of Staphylococcus aureus Biofilm Formation through Subinhibitory Concentrations of Biogenic Silver Nanoparticles and Simvastatin
by Ana Carolina Furian da Silva, Sindy Magri Roque, Marta Cristina Teixeira Duarte, Gerson Nakazato, Nelson Durán and Karina Cogo-Müller
Future Pharmacol. 2024, 4(1), 3-16; https://doi.org/10.3390/futurepharmacol4010002 - 5 Jan 2024
Cited by 1 | Viewed by 1780
Abstract
Staphylococcus aureus is a causative agent of nosocomial infections and its antibiotic-resistant strains give cause for concern. Solutions are being explored to improve treatment for these infections, including repositioning drugs such as statins and using nanoparticles with antimicrobial properties. This study evaluated the [...] Read more.
Staphylococcus aureus is a causative agent of nosocomial infections and its antibiotic-resistant strains give cause for concern. Solutions are being explored to improve treatment for these infections, including repositioning drugs such as statins and using nanoparticles with antimicrobial properties. This study evaluated the antimicrobial effects of simvastatin (SIM) and biologically synthesized silver nanoparticles (bio-AgNPs) in isolate form and in combination using assays of minimum inhibitory concentration (MIC), an in vitro biofilm model, and the association of antimicrobials against clinical strains of S. aureus. Bio-AgNPs showed a 53.8 ± 1.23 nm mean diameter and standard deviation, a 0.23 polydispersity index, and a −25.66 ± 2.19 mV mean potential and standard deviation. Transmission electron microscopy confirmed the formation of nanoparticles, and the presence of Ag0 and AgCl. S. aureus strains were sensitive to bio-AgNPs and SIM, showing 31.88–187.5 and 74.66–149.32 μM concentrations, respectively. The association assay showed 2.0 fractional inhibitory concentration indices (i.e., indifferent for clinical strains) and 0.32 values for the standard ATCC 29213 strain (synergy). Biofilm inhibition assays with isolated SIM and bio-AgNPs showed decreased biofilm formation 4× to ⅛ MICs concentrations, showing no synergism in association. These findings evince that simvastatin and bio-AgNPs at subinhibitory concentrations can serve as antimicrobial agents against S. aureus biofilm. Full article
(This article belongs to the Special Issue Recent Advances in Pharmaceutical and Biomedical Analysis)
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