Hydrogel for Sustained Delivery of Therapeutic Agents (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1648

Special Issue Editors


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Guest Editor
Department of Chemical Kinetics, “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 060021 Bucharest, Romania
Interests: physical chemistry, physico-chemical characterization of materials; drug delivery; pharmaceuticals development; thermal analysis; kinetics; biopolymers, cyclodextrin inclusion complexes; hydrogels; biomaterials for biomedical applications; oxide materials design/synthesis and the thermoreactivity of precursor-oxide transformations; green chemistry; thermal properties; physicochemical characterization; nanomaterials for biomedicine; nanomaterials for energy applications; catalysis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
“Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 060021 Bucharest, Romania
Interests: gels; hydrogels; drug delivery; biomaterials; biomedical and pharmaceutical applications of gels; engineered gels for environmental applications; applications of gel-based materials and their composites in energy generation and storage; sensors; piezoelectric materials; nanomaterials for biomedical applications; regenerative medicine; green chemistry applications; green design in sustainable chemistry; biotechnology; green catalysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymer hydrogels are attractive materials utilized for the controlled release of drugs and therapeutic agents due to their ability to embed biologically active agents in 3D-water-swollen networks. The latest advancements in natural biomaterials, polymer chemistry and the bioengineering domain have facilitated numerous developments in the field of hydrogels for the sustained delivery of therapeutic agents. In light of this, the current Special Issue is focused on the state of the art in the field of hydrogels, focusing on several exciting subjects, including cross-linking methods, stimuli-responsive hydrogels, multicomponent hydrogels, aerogels and the release of therapeutic agents from 3D-printed hydrogels. Therefore, the challenges that have been overcome due to advancements in the fields of biodegradable, biocompatible and temperature- and pH-stimuli-responsive hydrogels and interactions between hydrogels and therapeutic agents will also be highlighted.

This Special Issue will also focus on the physical, chemical, pharmacotechnical and biological characterization of polymer hydrogels using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), rheology and thermal analysis methods and their applications in regenerative medicine and pharmacy. The structure–property relationships of hydrogels are necessary to establish a correlation between the design and shape of a polymer hydrogel and the different drug delivery applications.

In this Special Issue, theoretical and experimental contributions in the forms of literature reviews, full-length original research articles and short communications are welcome.

We welcome and look forward to your submissions.

Dr. Adina Magdalena Musuc
Dr. Magdalena Mititelu
Dr. Mariana Chelu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • hydrogels
  • drug delivery
  • therapeutic agents
  • natural biopolymers
  • aerogels
  • polymer gels properties
  • biomedical applications
  • tissue engineering
  • smart hydrogels
  • stimuli-responsive gels
  • biomaterials
  • physical-chemical characterization
  • 3D printing
  • structure-property relationship
  • regenerative medicine

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Published Papers (1 paper)

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Review

33 pages, 3588 KiB  
Review
Development and Applications of PLGA Hydrogels for Sustained Delivery of Therapeutic Agents
by Anita Ioana Visan and Irina Negut
Gels 2024, 10(8), 497; https://doi.org/10.3390/gels10080497 - 26 Jul 2024
Viewed by 1247
Abstract
Poly(lactic-co-glycolic acid) (PLGA) hydrogels are highly utilized in biomedical research due to their biocompatibility, biodegradability, and other versatile properties. This review comprehensively explores their synthesis, properties, sustained release mechanisms, and applications in drug delivery. The introduction underscores the significance of PLGA hydrogels in [...] Read more.
Poly(lactic-co-glycolic acid) (PLGA) hydrogels are highly utilized in biomedical research due to their biocompatibility, biodegradability, and other versatile properties. This review comprehensively explores their synthesis, properties, sustained release mechanisms, and applications in drug delivery. The introduction underscores the significance of PLGA hydrogels in addressing challenges like short half-lives and systemic toxicity in conventional drug formulations. Synthesis methods, including emulsion solvent evaporation, solvent casting, electrospinning, thermal gelation, and photopolymerization, are described in detail and their role in tailoring hydrogel properties for specific applications is highlighted. Sustained release mechanisms—such as diffusion-controlled, degradation-controlled, swelling-controlled, and combined systems—are analyzed alongside key kinetic models (zero-order, first-order, Higuchi, and Peppas models) for designing controlled drug delivery systems. Applications of PLGA hydrogels in drug delivery are discussed, highlighting their effectiveness in localized and sustained chemotherapy for cancer, as well as in the delivery of antibiotics and antimicrobials to combat infections. Challenges and future prospects in PLGA hydrogel research are discussed, with a focus on improving drug loading efficiency, improving release control mechanisms, and promoting clinical translation. In summary, PLGA hydrogels provide a promising platform for the sustained delivery of therapeutic agents and meet diverse biomedical requirements. Future advancements in materials science and biomedical engineering are anticipated to further optimize their efficacy and applicability in clinical settings. This review consolidates the current understanding and outlines future research directions for PLGA hydrogels, emphasizing their potential to revolutionize therapeutic delivery and improve patient outcomes. Full article
(This article belongs to the Special Issue Hydrogel for Sustained Delivery of Therapeutic Agents (2nd Edition))
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