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Genes
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Advances in Genetics and Genomics of Parasites
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Advances in Genetics and Genomics of Parasites

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 1948

Special Issue Editor

Prof. Dr. Guanghui Zhao

E-Mail Website
Guest Editor
Department of Parasitology, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
Interests: parasites; genetics; genomics; population structure; epidemiology; host–parasite interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in high-throughput automated DNA sequencing have enabled large-scale genomic sequencing to be a cost-effective and time-efficient approach to understand the biology and host interactions of parasites, and the continued development and implementation of new software tools further promote the final realization of the potential rewards of genome sequencing. Sequencing data from large numbers of laboratory lines and field isolates of a great number of parasites have advanced rapidly for studies of genome diversity, parasite evolution, population genetics, drug resistances, and pathogenesis. More recently, single-cell sequencing techniques have begun to yield exciting information for mixed infections, genetic recombination, and differentiation of parasites.

This Special Issue will focus on the development and application of such technologies associated with genetics and genomics of parasites in animals and humans.

Prof. Dr. Guanghui Zhao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • high-throughput automated DNA sequencing
  • single-cell sequencing techniques
  • parasite
  • genetics
  • genomics

Published Papers (1 paper)

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Research

11 pages, 2327 KiB  
Article
A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B
by Estefan Miranda-Miranda, Silvana Scarcella, Enrique Reynaud, Verónica Narváez-Padilla, Gisela Neira, Roberto Mera-y-Sierra, Hugo Aguilar-Díaz and Raquel Cossio-Bayugar
Genes 2022, 13(10), 1899; https://doi.org/10.3390/genes13101899 - 19 Oct 2022
Cited by 1 | Viewed by 1331
Abstract
Fasciola hepatica anthelmintic resistance may be associated with the catalytic activity of xenobiotic metabolizing enzymes. The gene expression of one of these enzymes, identified as carboxylesterase B (CestB), was previously described as inducible in adult parasites under anthelmintic treatment and exhibited a single [...] Read more.
Fasciola hepatica anthelmintic resistance may be associated with the catalytic activity of xenobiotic metabolizing enzymes. The gene expression of one of these enzymes, identified as carboxylesterase B (CestB), was previously described as inducible in adult parasites under anthelmintic treatment and exhibited a single nucleotide polymorphism at position 643 that translates into a radical amino acid substitution at position 215 from Glutamic acid to Lysine. Alphafold 3D models of both allelic sequences exhibited a significant affinity pocket rearrangement and different ligand-docking modeling results. Further bioinformatics analysis confirmed that the radical amino acid substitution is located at the ligand affinity site of the enzyme, affecting its affinity to serine hydrolase inhibitors and preferences for ester ligands. A field genotyping survey from parasite samples obtained from two developmental stages isolated from different host species from Argentina and Mexico exhibited a 37% allele distribution for 215E and a 29% allele distribution for 215K as well as a 34% E/K heterozygous distribution. No linkage to host species or geographic origin was found in any of the allele variants. Full article
(This article belongs to the Special Issue Advances in Genetics and Genomics of Parasites)
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