Effects of Physical Exercise on Cardiometabolic Disorders

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Public Health and Preventive Medicine".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 916

Special Issue Editors


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Guest Editor
Department of Physiotherapy, Federal University of São Carlos, São Carlos 13565905, Brazil
Interests: cardiovascular system; autonomic nervous system; metabolism; exercise; physiology; aging; chronic disease

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Guest Editor
Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, SP, Brazil
Interests: exercise; physiology; aging; metabolism; obesity; chronic disease; high-intensity interval training
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Guest Editor
Department of Health, LUNEX University of Applied Sciences, 4671 Differdange, Luxembourg
Interests: cardiovascular system; autonomic nervous system; exercise; physiology; chronic disease; high-intensity interval training
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Physical exercise has been linked to several beneficial effects on the human body. These effects help to reduce physiological stresses experienced in everyday life. Cardiometabolic disorders are currently in evidence due to contemporary lifestyles, and the beneficial effects of physical exercise can help in the prevention and treatment of these disorders.

The literature shows a significant increase in the prevalence of cardiometabolic diseases in recent decades. Inflammation, metabolic dysfunction, and cardiovascular autonomic imbalance are, at the same time, the cause and consequence of these diseases. However, the relationship between such factors and the practice of physical exercise remains to be elucidated. In this sense, a collection of studies on the effects of exercise on cardiometabolic diseases can generate knowledge about this topic and assist in the development of treatments that aim to improve clinical conditions.

We are pleased to invite you to contribute to this Special Issue that aims to investigate the effects of physical exercise on cardiometabolic disorders. This includes how exercise can help prevent and treat these disorders.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Systematic/scoping reviews or clinical trials about how physical exercise prevents and/or treats cardiometabolic conditions;
  • Cross-sectional and comparative studies that highlight the relationship between physical exercise and cardiometabolic impact;
  • Studies involving (but not limited to) metabolism and/or cardiovascular autonomic modulation are welcome.

We look forward to receiving your contributions.

Dr. Étore De Favari Signini
Dr. Alex Castro
Dr. Raphael Martins de Abreu
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exercise
  • physical conditioning
  • cardiovascular system
  • metabolism
  • disease
  • cardiometabolic risk factors
  • cardiovascular diseases
  • autonomic nervous system
  • inflammation

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Published Papers (1 paper)

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Research

14 pages, 734 KB  
Article
Complexity of Cardiovascular Regulation and Its Association with Physical and Cardiorespiratory Fitness in Men with Type 2 Diabetes Mellitus
by Étore De F. Signini, Raphael M. de Abreu, Alex Castro, Andréia M. Santos, Gabriela A. M. Galdino, Silvia C. G. Moura, Stephanie N. Linares, Juliana C. Milan-Mattos, Rafaella M. Zambetta, Alberto Porta and Aparecida M. Catai
Healthcare 2026, 14(7), 940; https://doi.org/10.3390/healthcare14070940 - 3 Apr 2026
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Abstract
Background/Objectives: Cardiovascular regulation complexity (CRC) is an underexplored health marker in the context of type 2 diabetes mellitus (T2DM). Additionally, associating CRC with physical and cardiorespiratory fitness variables could provide greater insight into how physical conditioning impacts cardiovascular health in the context [...] Read more.
Background/Objectives: Cardiovascular regulation complexity (CRC) is an underexplored health marker in the context of type 2 diabetes mellitus (T2DM). Additionally, associating CRC with physical and cardiorespiratory fitness variables could provide greater insight into how physical conditioning impacts cardiovascular health in the context of T2DM. This study aims to investigate whether the relationship between physical and cardiorespiratory fitness and CRC differs according to the presence or absence of T2DM. Methods: Sixty-eight men were equally divided into the T2DM group (T2DMG; 57 ± 6 years old and 28.4 ± 3.1 kg/m2) and the control group (CG; 52 ± 5 years old and 25.1 ± 2.8 kg/m2). Participants underwent a resting cardiovascular data collection and a cardiopulmonary exercise test on a cycle ergometer. For each group, the relative peak power (W/kgPEAK) and peak oxygen consumption (VO2PEAK) were correlated with the CRC indices, namely, Shannon entropy, the complexity index, the normalized complexity index, and the sample entropy from heart period (HP) and systolic arterial pressure (SAP) series. A partial correlation was performed for each group, controlling for age, physical activity level, and metabolic cart. Results: Only the CG showed positive and significant correlations between relative VO2PEAK and W/kgPEAK and CRC indices derived from the HP series (0.354 ≤ r ≤ 0.548 and 0.001 ≤ p ≤ 0.047). Correlations with the SAP series were not significant, regardless of the groups. Conclusions: In this sample, there was no positive relationship between physical and cardiorespiratory fitness variables and CRC indices among individuals with T2DM. Further large sample studies are needed to elucidate the factors involved in T2DM that impact CRC. Full article
(This article belongs to the Special Issue Effects of Physical Exercise on Cardiometabolic Disorders)
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