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2nd Edition of Cancer in Human Health and Healthcare
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2nd Edition of Cancer in Human Health and Healthcare

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 14714

Special Issue Editor

Dr. Rahena Akhter

E-Mail Website
Guest Editor
School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Camperdown 2006, Australia
Interests: caries risk assessment; caries management system; minimal intervention dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

This Special Issue will facilitate the publication of high-quality original research and review articles pertaining to the genetic, genomic, and molecular aspects of cancer and its relation to systemic disease and technical advances that facilitate progress in this field. 

The aim of this journal is to provide a platform for researchers, physicians, surgeons, and academicians around the globe to promote, share, and discuss various new issues and developments in the different fields of oral cancer, as well as correlation of genetic changes with pathology and clinical presentation, and the molecular genetics of cancer predisposition. To reach a basic science and clinical multidisciplinary audience, we welcome original full-length articles, reviews, and editorials on epidemiology, prevention, clinical features, diagnosis, treatment, and management of patients with neoplasms in the head and neck as well as its relation to systemic diseases. 

Dr. Rahena Akhter
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral health
  • systemic disease
  • molecular biology
  • oral pathology
  • cancer-related genetics
  • head and neck squamous cell carcinoma

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

19 pages, 11742 KiB  
Article
Cause of Death among Long-Term Cancer Survivors: The NANDE Study
by Makoto Fujii, Toshitaka Morishima, Mayumi Nagayasu, Haruka Kudo, Yuko Ohno, Tomotaka Sobue and Isao Miyashiro
Healthcare 2023, 11(6), 835; https://doi.org/10.3390/healthcare11060835 - 13 Mar 2023
Cited by 3 | Viewed by 3211
Abstract
Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985–2014) and vital statistics data (1985–2016) were linked to create a database, permitting [...] Read more.
Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985–2014) and vital statistics data (1985–2016) were linked to create a database, permitting the extraction of data on the causes of death. In total, 522,566 subjects diagnosed with cancer between 1995 and 2011 were analyzed. Follow-up for vital status was conducted 5 and 10 years after cancer diagnosis. To evaluate the three causes of death (index cancer, non-index cancer, and non-cancer death), cause-specific hazard and cumulative incidence functions were estimated using a life table and Gray’s methods. The number of deaths owing to any of the causes in the observation period (median: 3.51 years, mean: 4.90 years) was 394,146. The 5- and 10-year cancer-specific survival rate was 48.56% and 39.92%, respectively. Immediately after cancer onset, the hazard of index cancer death was high. The proportion of non-index cancer deaths was high in patients with mouth and pharynx cancers. The hazard of index cancer death remained constant for breast and liver cancers. In prostate, breast, and laryngeal cancers with good prognosis, the hazard of non-index cancer and non-cancer death constantly increased. Full article
(This article belongs to the Special Issue 2nd Edition of Cancer in Human Health and Healthcare)
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10 pages, 2638 KiB  
Article
Metformin Therapy and Breast Cancer Incidence in the Ha’il Region
by Mhdia Osman, Taif Muqbel, Ahad Abduallh, Shuruq Alanazi, Nasrin E. Khalifa, Weam M. A. Khojali, Halima Mustafa Elagib, Weiam Hussein and Marwa H. Abdallah
Healthcare 2023, 11(3), 321; https://doi.org/10.3390/healthcare11030321 - 20 Jan 2023
Cited by 2 | Viewed by 2184
Abstract
Background: Metformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease is related to insulin resistance and multiplied blood [...] Read more.
Background: Metformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease is related to insulin resistance and multiplied blood sugar ranges. Furthermore, it has been established that the use of metformin improves the menstrual cycles and ovulation rates of these women. Methods: A structured questionnaire was conducted to determine the prevalence of breast cancer among women using metformin in the Ha’il region. Result: The incidence of breast cancer among women using metformin in the Ha’il region is very low. Thus, it can be said that breast cancer cases declined among diabetics taking metformin. This means that metformin use is associated with a lower risk of breast cancer in women with type 2 diabetes, even in cases where these women have a family history of breast cancer. Conclusions: According to previous findings, metformin has been linked to lower breast cancer risk in women with type 2 diabetes. Furthermore, the findings of this study corroborate the literature on this subject by indicating that there is a substantial connection between metformin use and a lower risk of breast cancer in women with type 2 diabetes. However, further in vitro and in vivo experiments are crucial to investigate the protective effect of metformin against breast cancer and to confirm our findings. Full article
(This article belongs to the Special Issue 2nd Edition of Cancer in Human Health and Healthcare)
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10 pages, 898 KiB  
Article
Effects of Structured Expressive Writing on Quality of Life and Perceived Self-Care Self-Efficacy of Breast Cancer Patients Undergoing Chemotherapy in Central China: A Randomized Controlled Trial
by Rong Wang, Lu Li, Jing Xu, Zhen-Ting Ding, Jia Qiao, Sharon R. Redding, Yun-Yan Xianyu and Yan-Qiong Ouyang
Healthcare 2022, 10(9), 1762; https://doi.org/10.3390/healthcare10091762 - 14 Sep 2022
Cited by 3 | Viewed by 3125
Abstract
Expressive writing is a supportive psychological intervention allowing an individual to disclose and express their deepest thoughts and feelings related to personal traumatic experiences through writing. Previous studies suggested that expressive writing could promote the physical and mental health of cancer patients. The [...] Read more.
Expressive writing is a supportive psychological intervention allowing an individual to disclose and express their deepest thoughts and feelings related to personal traumatic experiences through writing. Previous studies suggested that expressive writing could promote the physical and mental health of cancer patients. The current study was conducted to evaluate the effect of expressive writing based on the theory of cognitive adaptation (TCA) on the quality of life and self-care self-efficacy in patients with breast cancer undergoing chemotherapy. A sample of 82 Chinese women receiving chemotherapy for breast cancer was randomly assigned to an experimental group (four 20 min writing activities focusing on emotional disclosure) or a control group (no writing activities). The quality of life (QoL) and self-care self-efficacy were assessed at baseline, 2 weeks, 4 weeks, and 6 weeks after the intervention, respectively. The sociodemographic characteristics, QoL, and self-care self-efficacy at baseline were comparable between the two groups. Repeated-measures ANOVA revealed significant effects of the time×group (F = 3.65, p < 0.05) on the QoL and significant effects of time (F = 4.77, p <0.05) on self-care self-efficacy. Compared with the control group, the QoL in the intervention group showed a significant and temporary increase at 2 weeks after the intervention (mean difference = −7.56, p < 0.05). As a low-cost and easily delivered psychological intervention, expressive writing is recommended to reduce stress when there is a lack of available emotional support. Full article
(This article belongs to the Special Issue 2nd Edition of Cancer in Human Health and Healthcare)
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13 pages, 3428 KiB  
Article
Neuroendocrine Tumors: An Analysis of Prevalence, Incidence, and Survival in a Hospital-Based Study in Ecuador
by Karime Montes Escobar, Jose Luis Vicente-Villardon, Rosa Elisa Villacís Gonzalez, Paul Humberto Castillo Cordova, Johanna Mabel Sánchez Rodríguez, Melina De la Cruz-Velez and Aline Siteneski
Healthcare 2022, 10(8), 1569; https://doi.org/10.3390/healthcare10081569 - 18 Aug 2022
Cited by 4 | Viewed by 2942
Abstract
Neuroendocrine tumors (NETs) represent a heterogeneous malignancy group of neoplasms, with a limited amount of data from Latin America. Thus, this observational study aimed to provide data about the prevalence, incidence, and survival rates for NET in Ecuadorian hospitals. The study was conducted [...] Read more.
Neuroendocrine tumors (NETs) represent a heterogeneous malignancy group of neoplasms, with a limited amount of data from Latin America. Thus, this observational study aimed to provide data about the prevalence, incidence, and survival rates for NET in Ecuadorian hospitals. The study was conducted using data from the Society for the Fight Against Cancer (SOLCA). We evaluated patients with NETs (2000–2020) using the HJ-Biplot method and Cox proportional hazards. Annual age-adjusted incidence and limited-duration prevalence in multivariable analyses as well as hazard ratios (HRs) for mortality and survival were obtained. In the years 2000–2020, the age-adjusted incidence rate increased by 9-fold in the stomach and by 7-fold in the breast. The incidence rates were 1.38 per 100,000 persons in the lung and at 1.79 per 100,000 persons in gastroenteropancreatic sites (rectum, stomach, and pancreas). The prevalence increased from 0.0027% in 2000 to 0.0736% in 2019 and 0.0245% in 2020. Overall survival was worse for metastatic NETs (HR, 4.061; 95% CI, 1.932–8.540; p < 0.001) and advanced local NETs (HR, 2.348; 95% CI, 1.007–5.475 p < 0.048) than for localized NETs. In conclusion, the NET incidence increased in the last 20 years and survival decreased over time, especially for metastatic tumors in the pancreas and the nostril. Full article
(This article belongs to the Special Issue 2nd Edition of Cancer in Human Health and Healthcare)
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13 pages, 3813 KiB  
Article
Earlier Detection of Brain Tumor by Pre-Processing Based on Histogram Equalization with Neural Network
by M. Ramamoorthy, Shamimul Qamar, Ramachandran Manikandan, Noor Zaman Jhanjhi, Mehedi Masud and Mohammed A. AlZain
Healthcare 2022, 10(7), 1218; https://doi.org/10.3390/healthcare10071218 - 29 Jun 2022
Cited by 16 | Viewed by 2491
Abstract
MRI is an influential diagnostic imaging technology specifically worn to detect pathological changes in tissues with organs early. It is also a non-invasive imaging method. Medical image segmentation is a complex and challenging process due to the intrinsic nature of images. The most [...] Read more.
MRI is an influential diagnostic imaging technology specifically worn to detect pathological changes in tissues with organs early. It is also a non-invasive imaging method. Medical image segmentation is a complex and challenging process due to the intrinsic nature of images. The most consequential imaging analytical approach is MRI, which has been in use to detect abnormalities in tissues and human organs. The portrait was actualized for CAD (computer-assisted diagnosis) utilizing image processing techniques with deep learning, initially to perceive a brain tumor in a person with early signs of brain tumor. Using AHCN-LNQ (adaptive histogram contrast normalization with learning-based neural quantization), the first image is preprocessed. When compared to extant techniques, the simulation outcome shows that this proposed method achieves an accuracy of 93%, precision of 92%, and 94% of specificity. Full article
(This article belongs to the Special Issue 2nd Edition of Cancer in Human Health and Healthcare)
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