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Per- and Polyfluorinated Substances (PFAS) Pollution and Exposure
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Per- and Polyfluorinated Substances (PFAS) Pollution and Exposure

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Chemoenvironment".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4815

Special Issue Editor

Prof. Dr. Joshua Oluwole Olowoyo

E-Mail Website
Guest Editor
Department of Biology, Sefako Makgatho Health Sciences University, Medunsa 0204, South Africa
Interests: pollution monitoring studies; trace metals; pharmaceuticals; PFAS

Special Issue Information

Dear Colleagues,

Per- and polyfluorinated substances (PFAS) are one of the newest contaminant classes garnering attention in the environmental health community because of their ubiquity, longevity, and potential for contributing to negative health outcomes across the lifespan. PFAS comprise more than 4500 complex compounds. Due to their resistance to grease, oil, water, and heat, these chemicals are used in everyday products including cookware, clothing, other textiles, furniture, food packaging, and firefighting foams, and they can contaminate our water, food, and air.

The research surrounding PFAS has exploded over the last several years, but much remains unknown. A large proportion of our current knowledge has been derived from overtly exposed populations. Although these populations have been the most harshly impacted, PFAS exposures are pervasive, and recent studies have recognized the need to study multiple life stages and exposure levels. Research on lower-level, chronic exposures is demonstrating that far more is yet to be revealed about PFAS exposures and adverse health outcomes.

The aim of the present Special Issue is to bring together up-to-date research on newly identified PFAS, exposure pathways, prenatal and early-childhood exposures, pregnancy and child health outcomes, and adult disease. Original research articles, review papers, and case reports are welcomed.

Prof. Dr. Joshua Oluwole Olowoyo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PFAS
  • PFAS exposure
  • health outcome
  • risk assessment

Published Papers (2 papers)

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Research

14 pages, 3811 KiB  
Article
Trends in Serum Per- and Polyfluoroalkyl Substance (PFAS) Concentrations in Teenagers and Adults, 1999–2018 NHANES
by Nilisha Khadgi Sonnenberg, Akinloye Emmanuel Ojewole, Catherine Oluwalopeye Ojewole, Otite Precious Lucky and Joseph Kusi
Int. J. Environ. Res. Public Health 2023, 20(21), 6984; https://doi.org/10.3390/ijerph20216984 - 27 Oct 2023
Cited by 9 | Viewed by 2774
Abstract
Some types of per- and poly-fluoroalkyl substances (PFAS) have been banned over the last two decades, but millions of Americans continue to have exposure to the compounds through drinking water and consumer products. Therefore, understanding the changes in serum PFAS concentrations after their [...] Read more.
Some types of per- and poly-fluoroalkyl substances (PFAS) have been banned over the last two decades, but millions of Americans continue to have exposure to the compounds through drinking water and consumer products. Therefore, understanding the changes in serum PFAS concentrations after their limited use is necessary to protect public health. In this study, we evaluated trends of serum PFAS compounds (PFOS, PFOA, PFHxS, PFDA, and PFNA) to determine their distribution among the United States general population. We analyzed serum concentrations of PFAS measured from random subsamples of the National Health and Nutrition Examination Survey (NHANES) participants. The study results demonstrated that demographic factors such as race/ethnicity, age, and sex may influence the levels of serum PFAS over time. Adults, males, Asians, Non-Hispanic Blacks, and Non-Hispanic Whites had high risks of exposure to the selected PFAS. Overall, serum PFAS levels declined continuously in the studied population from 1999 to 2018. Among the studied population, PFOS and PFDA were the most and least prevalent PFAS in blood serum, respectively. Serum levels of PFDA, PFOA, and PFHxS showed upward trends in at least one racial/ethnic group after 2016, which underscores the need for continuous biomonitoring of PFAS levels in humans and the environment. Full article
(This article belongs to the Special Issue Per- and Polyfluorinated Substances (PFAS) Pollution and Exposure)
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23 pages, 3244 KiB  
Article
Serum Levels of CXCR4, SDF-1, MCP-1, NF-κB and ERK1/2 in Patients with Skeletal Fluorosis
by Yaqian Zhao, Guanglan Pu, Yanan Li, Hong Jiang, Qiang Zhang, Ping Chen, Qing Lu, Mingjun Wang and Rui Yang
Int. J. Environ. Res. Public Health 2022, 19(24), 16555; https://doi.org/10.3390/ijerph192416555 - 9 Dec 2022
Cited by 3 | Viewed by 1404
Abstract
C-X-C motif chemokine receptor 4 (CXCR4), stromal cell-derived factor-1 (SDF-1), monocyte chemoattractant protein-1 (MCP-1), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) affect bone cells and play an important role in bone and joint diseases, but the data on CXCR4, SDF-1, MCP-1, [...] Read more.
C-X-C motif chemokine receptor 4 (CXCR4), stromal cell-derived factor-1 (SDF-1), monocyte chemoattractant protein-1 (MCP-1), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) affect bone cells and play an important role in bone and joint diseases, but the data on CXCR4, SDF-1, MCP-1, ERK1/2 and NF-κB in the serum of skeletal fluorosis (SF) patients are inconclusive. Thus, according to the “Diagnostic Criteria for Endemic Skeletal Fluorosis” (WS 192-2008), we enrolled patients with SF (n = 60) as the SF group and those without SF as the controls (n = 60). Serum levels of CXCR4, SDF-1, MCP-1, ERK1/2 and NF-κB were detected by enzyme-linked immunosorbent assays (ELISAs). Serum SDF-1, CXCR4, MCP-1 and NF-κB levels were significantly higher in the SF group than in the control group. Within the serum of SF patients, CXCR4 and SDF-1 levels were positively correlated with NF-κB levels. There was no correlation between MCP-1 levels and those of ERK1/2 or NF-κB. SDF-1 and CXCR4 may activate the NF-κB pathway, and MCP-1 affects the occurrence and development of SF by regulating osteocytes through other pathways. The SDF-1/CXCR4 axis and MCP-1 signalling pathway provide a new theoretical basis for the occurrence and development of SF. Full article
(This article belongs to the Special Issue Per- and Polyfluorinated Substances (PFAS) Pollution and Exposure)
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