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Cognitive Impairment, Dementia and Alzheimer's Disease

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Aging".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 6795

Special Issue Editor


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Guest Editor
Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
Interests: Alzheimer's disease; neurodegenerative diseases; neurodegeneration; mild cognitive impairment; memory; neuroimaging; cognition disorders; learning and memory; brain imaging; functional neuroimaging

Special Issue Information

Dear Colleagues,

In aged and super-aged societies, the socioeconomic burden of cognitive impairment and dementia is increasing rapidly. There have been attempts at early diagnosis and disease-modifying treatment, but the current outcomes are limited. This is because cognitive impairment and dementia are multifactorial disorders probabilistically determined by genetic vulnerability and environmental factors. In this regard, cognitive impairment and dementia are among the areas that most require an integrated approach.

This Special Issue will focus on works with an integrated approach, aiming at a deeper understanding of pathologic aging and neurodegenerative disease. The Guest Editor is seeking original research and reviews (systematic reviews and meta-analyses) on the following topics.

  • Investigation of pathogenesis using a multimodal methodology;
  • The influence of chronic disease on cognitive impairment and dementia (diabetes mellitus, hypertension, thyroid disease, osteoporosis, etc.);
  • The effect of lifestyle and environmental factors on cognitive impairment and dementia (physical activity, smoking, air pollution, caffeine consumption, etc.);
  • Non-pharmacological treatments, including brain stimulation therapy, digital drug, stem-cell therapy, etc.;
  • Psychosocial factors affecting the progression of cognitive impairment and dementia (personality, education, social network, socioeconomic status, etc.).

Dr. Dong-Woo Kang
Guest Editor

Manuscript Submission Information

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Keywords

  • cognitive impairment
  • dementia
  • Alzheimer’s disease
  • pathogenesis
  • chronic disease
  • lifestyle factor
  • environmental factor
  • non-pharmacological treatment
  • psychosocial factor

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Published Papers (3 papers)

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Research

13 pages, 687 KiB  
Article
Association of Religious Service Attendance and Neuropsychiatric Symptoms, Cognitive Function, and Sleep Disturbances in All-Cause Dementia
by Katherine Carroll Britt, Kathy C. Richards, Gayle Acton, Jill Hamilton and Kavita Radhakrishnan
Int. J. Environ. Res. Public Health 2023, 20(5), 4300; https://doi.org/10.3390/ijerph20054300 - 28 Feb 2023
Cited by 3 | Viewed by 1835
Abstract
Commonly reported in dementia, neuropsychiatric symptoms (NPS), cognitive decline, and sleep disturbances indicate dementia progression. With the growing dementia burden, identifying protective factors that may slow dementia progression is increasingly essential. Religion and spirituality are associated with better mental and physical health, yet [...] Read more.
Commonly reported in dementia, neuropsychiatric symptoms (NPS), cognitive decline, and sleep disturbances indicate dementia progression. With the growing dementia burden, identifying protective factors that may slow dementia progression is increasingly essential. Religion and spirituality are associated with better mental and physical health, yet few studies have been reported in older adults with dementia. This study examines associations between religious service attendance and symptoms of dementia progression. Using data from the Health and Retirement Study in 2000, 2006, and 2008 and the sub-study, Aging, Demographics, and Memory Study in 2001–2003, 2006–2007, and 2008–2009, we examined the association of religious attendance with neuropsychiatric symptoms, cognitive function, and sleep disturbances among U.S. older adults aged 70 years and older with all-cause dementia (N = 72) using Spearman’s partial Rho correlation controlling for social interaction. Significant associations were identified for religious attendance and NPS (rs (97) = –0.124, 95% CI [–0.129, –0.119], p < 0.0005); cognitive function, rs (97) = –0.018, 95% CI [–0.023, –0.013], p < 0.001); and sleep disturbances, rs (97) = –0.275, 95% CI [–0.280, –0.271], p < 0.0005). Beyond adjusting for social interaction, increased religious attendance was associated with lower NPS, better cognitive function, and fewer sleep disturbances. Clinical trials and longitudinal studies with a larger sample size examining religion and spirituality factors with dementia progression are warranted. Full article
(This article belongs to the Special Issue Cognitive Impairment, Dementia and Alzheimer's Disease)
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18 pages, 2662 KiB  
Article
A Scalable Program for Improving Physical Activity in Older People with Dementia Including Culturally and Linguistically Diverse (CALD) Groups Who Receive Home Support: A Feasibility Study
by Den-Ching A. Lee, Terry P. Haines, Michele L. Callisaya and Keith D. Hill
Int. J. Environ. Res. Public Health 2023, 20(4), 3662; https://doi.org/10.3390/ijerph20043662 - 18 Feb 2023
Cited by 3 | Viewed by 1977
Abstract
Home care clients with dementia/cognitive impairment are typically functionally dependent and physically inactive. We pilot-tested a co-designed physical exercise program for its feasibility, safety, adherence and potential for benefits on physical activity, physical function, healthcare use and falls. Trained community care support workers [...] Read more.
Home care clients with dementia/cognitive impairment are typically functionally dependent and physically inactive. We pilot-tested a co-designed physical exercise program for its feasibility, safety, adherence and potential for benefits on physical activity, physical function, healthcare use and falls. Trained community care support workers delivered a 12-week home exercise program to clients with dementia/cognitive impairment, once weekly for 15 min during care shifts, supplemented by carers’ supervision of exercises for 30 min, three times weekly. A physiotherapist provided fortnightly phone support to ensure safety and exercise progression. Baseline and Week 12 assessments using validated scales for physical activity, physical function, daily living independence, falls efficacy, quality of life, self-reported healthcare use, falls and sleep quality were undertaken. Differences were examined with regression analyses. Care support workers (n = 26) and client/carer dyads (n = 26 and 80.8% culturally and linguistically diverse) participated. Participants recorded adverse events/falls and exercises in dairies. Fifteen dyads completed the program. No falls/adverse events occurred with the exercises. The adherence rates against targets for exercise time completed and days in which exercise were undertaken for support workers were 137%/79.6%, and for client/carer dyads were 82%/104.8%, respectively. Physical activity participation, physical function and falls efficacy significantly improved at Week 12 compared to baseline. The feasibility, safety and adherence of the co-designed physical exercise program were demonstrated. Strategies to minimise dropouts in future effectiveness studies are required. Full article
(This article belongs to the Special Issue Cognitive Impairment, Dementia and Alzheimer's Disease)
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10 pages, 1498 KiB  
Article
Relationships of Physical Activity, Depression, and Sleep with Cognitive Function in Community-Dwelling Older Adults
by Kahee Kim, Gyubeom Hwang, Yong Hyuk Cho, Eun Jwoo Kim, Ji Won Woang, Chang Hyung Hong, Sang Joon Son and Hyun Woong Roh
Int. J. Environ. Res. Public Health 2022, 19(23), 15655; https://doi.org/10.3390/ijerph192315655 - 25 Nov 2022
Cited by 4 | Viewed by 2291
Abstract
This cross-sectional, observational study aimed to integrate the analyses of relationships of physical activity, depression, and sleep with cognitive function in community-dwelling older adults using a single model. To this end, physical activity, sleep, depression, and cognitive function in 864 community-dwelling older adults [...] Read more.
This cross-sectional, observational study aimed to integrate the analyses of relationships of physical activity, depression, and sleep with cognitive function in community-dwelling older adults using a single model. To this end, physical activity, sleep, depression, and cognitive function in 864 community-dwelling older adults from the Suwon Geriatric Mental Health Center were assessed using the International Physical Activity Questionnaire, Montgomery-Asberg Depression Rating Scale, Pittsburgh Sleep Quality Index, and Mini-Mental State Examination for Dementia Screening, respectively. Their sociodemographic characteristics were also recorded. After adjusting for confounders, multiple linear regression analysis was performed to investigate the effects of physical activity, sleep, and depression on cognitive function. Models 4, 5, 7, and 14 of PROCESS were applied to verify the mediating and moderating effects of all variables. Physical activity had a direct effect on cognitive function (effect = 0.97, p < 0.01) and indirect effect (effect = 0.36; confidence interval: 0.18, 0.57) through depression. Moreover, mediated moderation effects of sleep were confirmed in the pathways where physical activity affects cognitive function through depression (F-coeff = 13.37, p < 0.001). Furthermore, these relationships differed with age. Thus, the associations among physical activity, depression, and sleep are important in interventions for the cognitive function of community-dwelling older adults. Such interventions should focus on different factors depending on age. Full article
(This article belongs to the Special Issue Cognitive Impairment, Dementia and Alzheimer's Disease)
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