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Oxidative Stress/Antioxidant Research
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Oxidative Stress/Antioxidant Research

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 8498

Special Issue Editors

Dr. Keshav Raj Paudel

E-Mail Website
Chief Guest Editor
Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia
Interests: atherosclerosis; vascular inflammation; cell migration; cell proliferation; rat model of vascular injury; obesity; inflammation marker; in vitro experiment; lung cancer, asthma; antioxidants; COPD; extracellular vesicles; breast cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Kamal Dua

E-Mail Website
Guest Editor
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
Interests: pharmaceutics; drug delivery; immunology; microbiology; chronic respiratory diseases
Dr. Murtaza M. Tambuwala

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, UK
Interests: nanoparticles; anti-inflamamtory; anti-cancer; anti-microbials; drug delviery; biomedical engineering; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress is a key hallmark of the progression of various diseases. An imbalance between reactive oxygen species (ROS) production and the antioxidant defence mechanisms of our body leads to oxidative stress. A high level of ROS is toxic to cells and may lead to damage to various cellular components, induce lipid peroxidation, activate immune cells etc. ROS are unstable reactive free radicals containing oxygen produced by various enzymes such as xanthine oxidase, nicotinamide adenine dinucleotide phosphate oxidase, and lipoxygenases in cells, including those produced by mitochondria or due to the uncoupling of nitric oxide synthase in vascular cells. Obesity, environmental pollutants, certain medications, exposure to radiation, cigarette smoking, chronic alcohol consumption, and the inhalation of/exposure to certain industrial chemicals or pesticides are risk factors for oxidative stress. Our body's immune system also produces ROS to combat pathogenic infections. Researchers are interested in targeting ROS production using various plant-based or synthetic promising antioxidants. The role of mitochondrial targeted antioxidants in ameliorating oxidative damage has recently been explored by various research labs around the globe.

This Special Issue of the journal International Journal of Environmental Research and Public Health, “Oxidative Stress/Antioxidant Research”, aims to cover recent research updates to highlight the promising findings in the field of oxidative stress/antioxidant research. Original articles, communications, and reviews related to these topics are welcome for submission.

Dr. Keshav Raj Paudel
Dr. Kamal Dua
Dr. Murtaza. M. Tambuwala
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidants
  • environmental toxin
  • drug delivery

Published Papers (3 papers)

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Research

11 pages, 1477 KiB  
Article
Rosinidin Protects against Cisplatin-Induced Nephrotoxicity via Subsiding Proinflammatory and Oxidative Stress Biomarkers in Rats
by Sadaf Jamal Gilani, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Sami I. Alzarea, Mohammed Muqtader Ahmed, Nadeem Sayyed and Imran Kazmi
Int. J. Environ. Res. Public Health 2022, 19(15), 9719; https://doi.org/10.3390/ijerph19159719 - 7 Aug 2022
Cited by 7 | Viewed by 1922
Abstract
Background: Rosinidin is a flavonoid anthocyanin pigmentation found in shrub flowers such as Catharanthus roseus and Primula rosea. The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range [...] Read more.
Background: Rosinidin is a flavonoid anthocyanin pigmentation found in shrub flowers such as Catharanthus roseus and Primula rosea. The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range of disorders. The current study intends to assess rosinidin nephroprotective efficacy against nephrotoxicity induced by cisplatin in rats. Materials and Methods: Oral acute toxicity tests of rosinidin were conducted to assess potential toxicity in animals, and it was shown to be safe. The nephroprotective effect of rosinidin 10, and 20 mg/kg were tested in rats for 25 days with concurrent administration of cisplatin. Several biochemical parameters were measured to support enzymatic and non-enzymatic oxidative stress such as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH). Likewise, changes in several non-protein-nitrogenous components and blood chemistry parameters were made to support the theory linked with the pathogenesis of chemical-induced nephrotoxicity. Results: Cisplatin caused significant changes in biochemical, enzymatic, and blood chemistry, which rosinidin efficiently controlled. Conclusions: The present investigation linked rosinidin with nephroprotective efficacy in experimental models. Full article
(This article belongs to the Special Issue Oxidative Stress/Antioxidant Research)
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17 pages, 4439 KiB  
Article
Efficient Production of Naringin Acetate with Different Acyl Donors via Enzymatic Transesterification by Lipases
by Yesol Baek, Seungmee Lee, Jemin Son, Taek Lee, Jong-Min Oh, Sang Hun Lee, Hyun Uk Kim, Sang Woo Seo, Si Jae Park, Hah Young Yoo and Chulhwan Park
Int. J. Environ. Res. Public Health 2022, 19(5), 2972; https://doi.org/10.3390/ijerph19052972 - 3 Mar 2022
Cited by 7 | Viewed by 2612
Abstract
Naringin, one of the citrus flavonoids and known as a natural antioxidant, has limited bioavailability owing to its low stability and solubility. However, naringin esters formed via acylation have recently been reported to possess improved physical and chemical properties. The development of these [...] Read more.
Naringin, one of the citrus flavonoids and known as a natural antioxidant, has limited bioavailability owing to its low stability and solubility. However, naringin esters formed via acylation have recently been reported to possess improved physical and chemical properties. The development of these compounds has a great potential in the food, cosmetic and pharmaceutical industries, but low conversion and productivity are barriers to industrial applications. This study aimed to improve the conversion of naringin acetate, which is formed via the enzymatic reaction between naringin and an acyl donor. An optimal reaction condition was determined by evaluating the effect of various variables (enzyme type, enzyme concentration, acyl donor, molar ratio of reactants, reaction temperature, and solvent) on the synthesis of naringin acetate. The optimal condition was as follows: 3 g/L of Lipozyme TL IM, molar ratio of 1:5 (naringin:acyl donor), reaction temperature of 40 °C, and acetonitrile as the reaction solvent. Under this condition, the maximum conversion to naringin acetate from acetic anhydride and vinyl acetate was achieved at approximately 98.5% (8 h) and 97.5% (24 h), respectively. Compared to the previously reported values, a high conversion was achieved within a short time, confirming the commercial potential of the process. Full article
(This article belongs to the Special Issue Oxidative Stress/Antioxidant Research)
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13 pages, 3258 KiB  
Article
N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues
by Ali Allam, Ahmed Abdeen, Hari Prasad Devkota, Samar S. Ibrahim, Gehan Youssef, Ahmed Soliman, Mohamed M. Abdel-Daim, Khalid J. Alzahrani, Khaled Shoghy, Samah F. Ibrahim and Mohamed Aboubakr
Int. J. Environ. Res. Public Health 2022, 19(2), 638; https://doi.org/10.3390/ijerph19020638 - 6 Jan 2022
Cited by 14 | Viewed by 2643
Abstract
Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It is commonly used in agriculture and veterinary medicine. Humans and animals are exposed to DLM through the ingestion of polluted food and water, resulting in severe health issues. N-acetylcysteine (NAC) [...] Read more.
Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It is commonly used in agriculture and veterinary medicine. Humans and animals are exposed to DLM through the ingestion of polluted food and water, resulting in severe health issues. N-acetylcysteine (NAC) is a prodrug of L-cysteine, the precursor to glutathione. It can restore the oxidant-antioxidant balance. Therefore, this research aimed to examine whether NAC may protect broiler chickens against oxidative stress, at the level of biochemical and molecular alterations caused by DLM intoxication. The indicators of liver and kidney injury in the serum of DLM-intoxicated and NAC-treated groups were examined. Furthermore, lipid peroxidation, antioxidant markers, superoxide dismutase activity, and apoptotic gene expressions (caspase-3 and Bcl-2) were investigated. All parameters were significantly altered in the DLM-intoxicated group, suggesting that DLM could induce oxidative damage and apoptosis in hepato-renal tissue. The majority of the changes in the studied parameters were reversed when NAC therapy was used. In conclusion, by virtue of its antioxidant and antiapoptotic properties, NAC enabled the provision of significant protection effects against DLM-induced hepato-renal injury. Full article
(This article belongs to the Special Issue Oxidative Stress/Antioxidant Research)
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