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The Benefit of Ketogenic Diet on Health Outcomes Such as Weight Loss, Serum Cholesterol, Type 2 Diabetes, and Hypertension

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 4302

Special Issue Editor


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Guest Editor
Tennessee Clinical and Translational Science Institute, University of Tennessee Health Science Center, Memphis, TN 38105, USA
Interests: nutrition; epidemiology; chronic diseases; cancer; cardiovascular diseases; metabolic syndrome

Special Issue Information

Dear Colleagues,

Chronic conditions such as type 2 diabetes, metabolic syndrome, obesity, cancer, and cardiovascular diseases have replaced infectious conditions and become the major causes of morbidity and mortality worldwide. Type 2 diabetes affects over 500 million people globally and the burden is steadily increasing over time. As global wealth increases, more and more people are starting to adopt a sedentary lifestyle and becoming exposed to more refined non-nutritious sugar-dense industrial food products, which make the situation even worse. Obesity and a related condition (i.e., metabolic syndrome) have reached an epidemic proportion globally, and interventions to reverse the trend face an uphill challenge as populations struggle with the health consequences.

There is a growing body of literature finding a beneficial effect of ketogenic (high fat, low carbohydrate, and moderate protein) diet on the weight loss, risk of type 2 diabetes, cancer, and cardiovascular diseases and their prognosis. However, the literature is still sparse, and more studies would help to determine the beneficial or adverse effects of ketogenic diets on the risk and prognosis of chronic diseases and other metabolic profiles including blood glucose and cholesterol.

In this Special Issue of the International Journal of Environmental and Public Health, we invite you to contribute research works evaluating the long-term beneficial and/or adverse effects of ketogenic diets and similar interventions for weight loss, risk, and progression of type 2 diabetes, cardiovascular diseases, cholesterol, and cancer using cohort or randomized controlled clinical trial study designs.

Dr. Daniel T. Dibaba
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ketogenic diet
  • low-carbohydrate diet
  • type 2 diabetes
  • cardiovascular health
  • cancer
  • metabolic syndrome
  • cholesterol

Published Papers (1 paper)

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Research

15 pages, 858 KiB  
Article
The Effects of Low-Energy Moderate-Carbohydrate (MCD) and Mixed (MixD) Diets on Serum Lipid Profiles and Body Composition in Middle-Aged Men: A Randomized Controlled Parallel-Group Clinical Trial
by Małgorzata Magdalena Michalczyk, Adam Maszczyk and Petr Stastny
Int. J. Environ. Res. Public Health 2020, 17(4), 1332; https://doi.org/10.3390/ijerph17041332 - 19 Feb 2020
Cited by 8 | Viewed by 3967
Abstract
Carbohydrate-restricted diets have become very popular due to their numerous health benefits. The aim of this study was to determine the influence of 4 weeks of a well-planned, low-energy moderate-carbohydrate diet (MCD) and a low-energy mixed diet (MixD) on the lipoprotein profile, glucose [...] Read more.
Carbohydrate-restricted diets have become very popular due to their numerous health benefits. The aim of this study was to determine the influence of 4 weeks of a well-planned, low-energy moderate-carbohydrate diet (MCD) and a low-energy mixed diet (MixD) on the lipoprotein profile, glucose and C-reactive protein concentrations, body mass, and body composition in middle-aged males. Sixty middle-aged males were randomly assigned to the following groups: hypocaloric MCD (32% carbohydrates, 28% proteins, and 40% fat), hypocaloric MixD (50% carbohydrates, 20% proteins, and 30% fat), and a conventional (control) diet (CD; 48% carbohydrates, 15% proteins, and 37% fat). The participants who were classified into the MCD and MixD groups consumed 20% fewer calories daily than the total daily energy expenditure (TDEE). Baseline and postintervention fasting triacylglycerol (TG), LDL (low-density lipoprotein) cholesterol (LDL-C), HDL (high-density lipoprotein) cholesterol (HDL-C), total cholesterol (tCh), glucose (Gl), and C-reactive protein were evaluated. Body mass (BM) and body composition changes, including body fat (BF), % body fat (PBF), and muscle mass (MM), were monitored. Compared with MixD and CD, MCD significantly changed the fasting serum concentrations of TG (p < 0.05), HDL-C (p < 0.05), LDL-C (p < 0.05), tCh (p < 0.05), and glucose (p < 0.01). Additionally, body fat content (kg and %) was significantly reduced (p < 0.05) after MCD compared with MixD and CD. After the MixD intervention, BM and MM decreased (p < 0.05) compared with baseline values. Compared with baseline, after the MixD, BM, MM, tCh, LDL-C, and TG changed significantly. The 4 week low-energy MCD intervention changed lipoproteins, glucose, and body fat to a greater extent than the low-energy MixD. A hypocaloric MCD may be suggested for middle-aged male subjects who want to lose weight by reducing body fat content without compromising muscle mass. Full article
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