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The Potential Health Benefits of Resveratrol
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The Potential Health Benefits of Resveratrol

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 29499

Special Issue Editor

Dr. Katarzyna Szkudelska

E-Mail Website
Guest Editor
Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637 Poznan, Poland
Interests: animal physiology; metabolism; endocrinology; metabolic diseases; diabetes; obesity; adipocyte metabolism

Special Issue Information

Dear Colleagues,

Resveratrol is a naturally occurring diphenolic compound. Animal studies have shown that resveratrol exerts numerous beneficial effects on the organism. The interest of researchers in studying the mechanisms regulating these effects has been growing steadily over the last 10 years. Resveratrol action is well established under various pathological conditions. It has been demonstrated to have, among others, anti-diabetic, anti-obesity, nephroprotective, hepatoprotective, neuroprotective, anti-cancer, anti-inflammatory, and antioxidant properties. Resveratrol also ameliorates ethanol-induced disturbances and is effective in rheumatoid arthritis. Moreover, it is well known that its ingestion is associated with cardiovascular benefits. The molecular mechanisms of resveratrol action are pleiotropic, and they are still being explained.

Animal studies have shown that long-term resveratrol treatment is safe since it is not accompanied by any side effects. Thus, this compound could be used to treat humans to support conventional therapies. However, resveratrol, similar to many other natural-derived compounds, may exert different effects in various tissues, and its action may not be dose-dependent. Therefore, further animal studies are required to assess the real therapeutic value of resveratrol.

The topic of the Special Issue focuses on molecular mechanisms, elucidating the health advantageous effects of resveratrol that enable its future use in human treatment.

Dr. Katarzyna Szkudelska
Guest Editor

Manuscript Submission Information

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Keywords

  • resveratrol
  • diseases
  • molecular mechanisms
  • animal studies
  • human studies
  • health protection

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Published Papers (2 papers)

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15 pages, 1261 KiB  
Article
Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes
by Beatriz Isabel García-Martínez, Mirna Ruiz-Ramos, José Pedraza-Chaverri, Edelmiro Santiago-Osorio and Víctor Manuel Mendoza-Núñez
Int. J. Mol. Sci. 2023, 24(8), 7422; https://doi.org/10.3390/ijms24087422 - 18 Apr 2023
Cited by 29 | Viewed by 4365
Abstract
Type 2 diabetes (T2D) affects a large part of the adult population and impairs its quality of life. Because of this, natural compounds with antioxidant, anti-inflammatory and hypoglycemic properties have been used as adjuvants. Among these compounds, resveratrol (RV) stands out, a polyphenol [...] Read more.
Type 2 diabetes (T2D) affects a large part of the adult population and impairs its quality of life. Because of this, natural compounds with antioxidant, anti-inflammatory and hypoglycemic properties have been used as adjuvants. Among these compounds, resveratrol (RV) stands out, a polyphenol that has been studied in several clinical trials, the results of which are controversial. We conducted a randomized clinical trial on 97 older adults with T2D to evaluate the effect of RV on oxidative stress markers and sirtuin 1, using doses of 1000 mg/day (EG1000, n = 37) and 500 mg/day (EG500, n = 32) compared with a placebo (PG, n = 28). Biochemical markers, oxidative stress and sirtuin 1 levels were measured at baseline and after six months. We observed a statistically significant increase (p < 0.05) in total antioxidant capacity, antioxidant gap, the percentage of subjects without oxidant stress and sirtuin 1 levels in EG1000. In the PG, we observed a significant increase (p < 0.05) in lipoperoxides, isoprostanes and C-reactive protein levels. An increase in the oxidative stress score and in the percentage of subjects with mild and moderate oxidative stress was observed too. Our findings suggest that 1000 mg/day of RV exerts a more efficient antioxidant effect than 500 mg/day. Full article
(This article belongs to the Special Issue The Potential Health Benefits of Resveratrol)
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Review

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52 pages, 3424 KiB  
Review
Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities
by Karen Brown, Despoina Theofanous, Robert G. Britton, Grandezza Aburido, Coral Pepper, Shanthi Sri Undru and Lynne Howells
Int. J. Mol. Sci. 2024, 25(2), 747; https://doi.org/10.3390/ijms25020747 - 6 Jan 2024
Cited by 43 | Viewed by 24568
Abstract
Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. A large cohort with high-quality clinical data and clearly defined biomarkers or endpoints [...] Read more.
Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. A large cohort with high-quality clinical data and clearly defined biomarkers or endpoints are required to draw meaningful conclusions. This systematic review compiles every clinical trial conducted using a defined dose of resveratrol in a purified form across multiple morbidities to highlight the current ‘state-of-play’ and knowledge gaps, informing future trial designs to facilitate the realisation of resveratrol’s potential benefits to human health. Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease. There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day. Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism. In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic. Full article
(This article belongs to the Special Issue The Potential Health Benefits of Resveratrol)
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