Metabolomics in the Field of Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 15 November 2024 | Viewed by 244
Special Issue Editors
Interests: metabolomics; NMR; GC-MS; multivariate statistical analysis; biomarkers
Special Issue Information
Dear Colleagues,
In total, 5–8% of the world’s population is affected by autoimmune diseases. Autoimmune diseases develop over several years and are the result of the impact of genetic and environmental factors in which the immune system is erroneously directed toward its host, and therefore characterized by the breakdown of self-tolerance.
Autoimmune diseases are classified as either organ-specific (e.g., type 1 diabetes, multiple sclerosis, inflammatory bowel disease, Hashimoto’s thyroiditis, autoimmune hepatitis and primary biliary cirrhosis, and celiac disease) or systemic (systemic lupus erythematosus, rheumatoid arthritis, Sjogren’s syndrome, systemic sclerosis, and systemic scleroderma). Although in recent years numerous immunological and molecular studies have shed light on the pathophysiological mechanisms of some autoimmune diseases, the complex interaction between genetic and environmental factors remains poorly understood. Furthermore, immunomodulatory drugs currently used for therapy have often not been fully successful and may be associated with important side effects.
The main -omics sciences, such as genomics, proteomics, and metabolomics, are now crucial for gaining a better understanding of the pathophysiological mechanisms underlying these diseases. The integration and communication between -omics data can lead to the identification of triggering factors, including environmental factors, and to the discovery of new diagnostic, prognostic, and predictive biomarkers of response to therapy for more refined treatments.
For this Special Issue, we invite you and your colleagues to submit original research articles, or comprehensive review articles related to recent advances in -omics technologies in the field of autoimmune diseases.
Dr. Cristina Piras
Dr. Federica Murgia
Guest Editors
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Keywords
- metabolomics
- proteomics
- genomics
- transcriptomics
- biomarkers
- autoimmune diseases
- inflammatory diseases
- nuclear magnetic resonance spectroscopy
- mass spectrometry
- precision medicine
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