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Natural-Derived Nanocarriers as Delivery Systems for Biomolecules

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 475

Special Issue Editor


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Guest Editor
Research Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino, 111, 80131 Naples, Italy
Interests: drug delivery system; bioactive molecules; green chemistry; molecular biology; biochemistry; exosomes-like vesicles; microRNAs regulation; in vitro inflammation/oxidation and cancer models

Special Issue Information

Dear Colleagues,

This Special Issue highlights the current state and future prospects of bioactive nanocarriers derived from natural sources (e.g., extracellular vesicles) able to elicit antioxidant, anti-inflammatory, antibacterial, and anti-proliferative activities, improving human health. Despite promising preclinical results, bioactive natural molecules have often been hindered by their poor stability, aqueous solubility, and bioavailability. Natural-derived nanocarriers have great potential for application in disease therapy as well as in the development of nanocarrier drug-delivery systems due to their physiological, chemical, and biological characteristics, including a relatively high internalization rate, low immunogenicity, stability in the gastrointestinal (GI) tract, and the ability to overcome the blood–brain barrier but not the placental barrier.

This topic comprises articles and reviews focused on the isolation, characterization, and application of natural-derived nanocarriers delivering biomolecules (e.g., miRNA, lipids, proteins, secondary metabolites, etc.) able to modulate healthcare-related metabolic pathways and/or genetic and/or epigenetic factors.

We are grateful to the authors who will participate in this issue of the International Journal of Molecular Sciences, and we hope that all articles herein will contribute to the development of this fascinating research and innovation field.

Dr. Anna Valentino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural nanocarriers
  • biomolecules
  • delivery systems
  • nanomedicine
  • human health
  • controlled release

Published Papers (1 paper)

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Research

18 pages, 7558 KiB  
Article
Extracellular Vesicles Derived from Opuntia ficus-indica Fruit (OFI-EVs) Speed Up the Normal Wound Healing Processes by Modulating Cellular Responses
by Anna Valentino, Raffaele Conte, Dalila Bousta, Hicham Bekkari, Anna Di Salle, Anna Calarco and Gianfranco Peluso
Int. J. Mol. Sci. 2024, 25(13), 7103; https://doi.org/10.3390/ijms25137103 - 28 Jun 2024
Viewed by 248
Abstract
Plant-derived extracellular vesicles (EVs) have been recognized as important mediators of intercellular communication able to transfer active biomolecules across the plant and animal kingdoms. EVs have demonstrated an impressive array of biological activities, displaying preventive and therapeutic potential in mitigating various pathological processes. [...] Read more.
Plant-derived extracellular vesicles (EVs) have been recognized as important mediators of intercellular communication able to transfer active biomolecules across the plant and animal kingdoms. EVs have demonstrated an impressive array of biological activities, displaying preventive and therapeutic potential in mitigating various pathological processes. Indeed, the simplicity of delivering exogenous and endogenous bioactive molecules to mammalian cells with their low cytotoxicity makes EVs suitable agents for new therapeutic strategies for a variety of pathologies. In this study, EVs were isolated from Opuntia ficus-indica fruit (OFI-EVs) and characterized by particle size distribution, concentration, and bioactive molecule composition. OFI-EVs had no obvious toxicity and demonstrated a protective role in the inflammatory process and oxidative stress in vitro model of chronic skin wounds. The results demonstrated that pretreatment with OFI-EVs decreased the activity and gene expression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-α) in the LPS-stimulated human leukemia monocytic cell line (THP-1). Furthermore, OFI-EVs promote the migration of human dermal fibroblasts (HDFs), speeding up the normal wound healing processes. This study sheds light, for the first time, on the role of OFI-EVs in modulating important biological processes such as inflammation and oxidation, thereby identifying EVs as potential candidates for healing chronic cutaneous wounds. Full article
(This article belongs to the Special Issue Natural-Derived Nanocarriers as Delivery Systems for Biomolecules)
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