Circulating Tumor Cells: Pathological, Molecular and Functional Characteristics 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 7753
Special Issue Editor
Interests: breast cancer; cell migration; cell adhesion; metastasis; circulating tumor cells; HAX1; entosis; RNA-binding proteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nowadays, therapeutic decisions are based overwhelmingly on the pathological and molecular characterization of the primary tumor. However, metastatic lesions can be highly heterogenous and substantially different from the primary neoplasm, which hampers the efficacy of treatments. Moreover, the inaccessibility of metastatic foci and the invasiveness of a biopsy represent challenging problems and call for some other means of secondary tumor characterization. The analysis of the circulating tumor cells (CTCs) as a surrogate for metastatic lesions is non-invasive and allows for a detailed characterization of the phenotype, genotype, heterogeneity, and expression profiling, as well as a functional analysis of tumor cells. These data should have a direct impact on the diagnosis and decision-making related to adjuvant treatment by helping with patient stratification and should also provide valuable information about the biology of metastasis. This open access Special Issue will bring together original research and review articles on CTCs, their biology, methods of enumeration and characterization, role in metastasis, and predictive value for diagnostics and therapeutic applications. It will provide a platform to share new discoveries, approaches, and technical developments in the field of CTC research for the development of the next generation of anti-metastasis treatments.
Topics of this Special Issue include, but are not limited to
- Diagnostic and therapeutic applications of CTC research;
- The biology of CTCs in different cancer types;
- CTC mobilization by treatment;
- Phenotypic/genotypic heterogeneity of CTCs;
- Technical developments in the isolation, enumeration, and characterization of CTCs;
- Functional analysis of CTCs, including culture and CDX;
- CTC analysis in single-cell resolution;
- Cell-free DNA vs. CTC;
- Epithelial/hybrid/mesenchymal properties of CTCs;
- CTC clusters: biology, enumeration, role in metastasis.
Dr. Ewa Grzybowska
Guest Editor
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Keywords
- CTC
- metastasis
- tumor heterogeneity
- invasion
- single-cell analysis
- cancer dissemination
- circulation
- treatment response
- CTC clusters
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