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Recent Insights on Macrocyclic-Based Hybrid Assemblies with Stimuli-Responsiveness

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1458

Special Issue Editors


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Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy
Interests: self-assembly; nanobiomaterials; nanomedicine; phototherapeutics; porphyrins; cyclodextrins; photodynamic therapy; supramolecular chirality

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Guest Editor
CNR-ISMN, URT of Messina c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy
Interests: supramolecular chemistry; self- assembly; chromophores; cyclodextrins; nanomaterials; nanotechnology; spectroscopy

Special Issue Information

Dear Colleagues,

Readily accessible, synthetic bio-soft macrocycles have gained the attention of the scientific community thanks to their increased versatility in medicinal chemistry. Stimuli-responsive  hybrid assemblies, based on both native and synthetic macrocycles, are a recently investigated research area in various fields,  ranging from chemistry to material science. In the field of nanomaterials for the treatment of damaging diseases, recent developments concerning single-molecule- and multi-stimuli-driven supramolecular hybrid assemblies have led from single- to multimodal therapeutic and diagnostic effects. With the incorporation of responsive functionalities, these hybrid nanoplatforms can be responsive to various stimuli, such as light, pH, heat, temperature, redox, enzymes, and magnetic fields. This Special Issue welcomes the submission of original research papers dedicated to noteworthy advances in macrocyclic-based hybrid assemblies and those obtained by supramolecular approaches, with stimuli-responsiveness in terms of design, synthesis, and applications. The focus of the research can be on the following topics:

  1. Design, synthesis, and characterization of novel macrocycle-based hybrids with stimuli-responsiveness;
  2. Supramolecular nanohybrids and hybrids with plasmonic, magnetic, redox, and luminescent properties;
  3. Supramolecular nanomaterials with phototherapeutic and photodiagnostic action;
  4. Theranostic assemblies.

Prof. Dr. Antonino Mazzaglia
Dr. Roberto Zagami
Dr. Mariachiara Trapani
Guest Editors

Manuscript Submission Information

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Keywords

  • stimuli-responsive materials
  • supramolecular hybrid assemblies
  • macrocyclic-based nanoassemblies
  • plasmonic nanoassemblies
  • magnetic nanoassemblies
  • phototherapeutic nanoassemblies
  • drug delivery
  • theranostic nanoassemblies

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Published Papers (1 paper)

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Research

10 pages, 1547 KiB  
Article
Comparative Study of the Antioxidant Activity of the Conformers of C-tetra(4-methoxyphenyl)calix[4]resorcinarene
by Laura Angélica Maldonado-Sanabria, Ivette Nicole Rodriguez-Saavedra, Ingrid Valentina Reyes-Peña, Alver Castillo-Aguirre, Mauricio Maldonado, Almudena Crespo and Miguel A. Esteso
Int. J. Mol. Sci. 2024, 25(18), 10010; https://doi.org/10.3390/ijms251810010 - 17 Sep 2024
Viewed by 896
Abstract
C-tetra(4-methoxyphenyl)calix[4]resorcinarene was synthesized by hydrochloric acid-catalysed cyclocondensation of resorcinol and 4-methoxybenzaldehyde. Under these conditions, the reaction produces a conformational mixture of crown and chair structural conformers, which were separated and characterized by chromatographic and spectroscopic techniques. The antioxidant activity of both conformers [...] Read more.
C-tetra(4-methoxyphenyl)calix[4]resorcinarene was synthesized by hydrochloric acid-catalysed cyclocondensation of resorcinol and 4-methoxybenzaldehyde. Under these conditions, the reaction produces a conformational mixture of crown and chair structural conformers, which were separated and characterized by chromatographic and spectroscopic techniques. The antioxidant activity of both conformers was measured by using the DPPH assay, through which it was observed that the chair conformer showed greater antioxidant activity (IC50 = 47.46 ppm) than the crown conformer (IC50 = 78.46 ppm). Additionally, it was observed that the mixture of both conformers presented lower antioxidant activity than either conformer in isolation. The results found suggest that the chair conformer has efficient antioxidant activity that makes it a potential target for further research. Full article
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