Wnt/β-Catenin Signaling in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 963
Special Issue Editors
Interests: cancer; gene expression
Interests: molecular biology assessment methods for hereditary susceptibility, gene expression assays, and cellular and tissue phenotypic markers involved in tumor onset and progression.
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Wnt signaling pathways are implicated in cell fate, migration, and polarity, as well as embryonic organogenesis, stem cell renewal, tissue homeostasis, and epithelial mesenchymal transition (EMT). Wnt signaling involves the canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway, which further comprises the Planar Cell Polarity and the Wnt/Ca2+ pathways. Aberrant activation of Wnt/β-catenin signaling is closely involved in the onset, development, and progression of numerous human malignant tumors and is predictive of poor prognosis. Therefore, deregulation of Wnt may represent an interesting therapeutic target in cancer treatment. So far, despite the efforts of researchers, the pleiotropic role of the Wnt/β-catenin pathway in critical cellular functions and the crosstalk with other signaling pathways have made the design of new targeted drugs difficult.
Understanding the role of Wnt/β-catenin signaling and its crosstalk pathways in cancer development can provide new insights into various pathogenetic mechanisms with the aim (1) to identify molecules of the Wnt signaling cascade that may represent potential prognostic and predictive markers of malignancy and (2) to develop new therapeutic approaches for defining molecular strategies useful in the pharmacological treatment of Wnt-related tumors.
In light of the above, in this Special Issue of the International Journal of Molecular Sciences on ‘Wnt/β-Catenin Signaling in Cancer’, we welcome original basic and translational research and review articles, which may help to elucidate the role played by Wnt signaling in tumor initiation, progression, and therapeutic response.
Dr. Teresa Catalano
Dr. Gitana Maria Aceto
Guest Editors
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Keywords
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Wnt/β-catenin pathway
- tumors
- gene expression
- molecular targets
- tumor microenvironment
- carcinogenesis and metastasis
- biomarkers
- therapeutic approaches
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