Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 66
Special Issue Editor
Interests: global cancer research; colorectal cancer; pancreatic cancer; cancer biology; cancer metastasis; cancer biomarkers; molecular biology; cell survival; apoptosis; signaling pathways; medical education
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. In the majority of cases, CRC begins as a benign adenomatous polyp, transitions into an advanced adenoma, and progresses to an invasive cancer. The best-studied molecular pathways involved in CRC can be broadly classified, based on their genetic mutation status, as oncogenic and tumor suppressor pathways. However, CRC is heterogeneous, and challenges exist in understanding the full spectrum of mechanisms that initiate its development and drive progression and metastasis, as well as in determining their responsiveness to anticancer therapeutic strategies.
Over the last decade, there have been major advances in the molecular profiling of CRC, significantly improving our understanding of CRC tumor heterogeneity and providing results for diagnostic classification and targeted treatment strategies. As a result, CRC treatment, particularly metastatic CRC, has evolved significantly, reflected by the use of many chemotherapeutic combinations and the integration of novel targeted therapies into clinical practice. However, the efficacy of these agents is often limited due to the rapid evolution of drug resistance and cancer recurrence.
Tumor heterogeneity is one of the main mechanisms of drug resistance in CRC, mainly due to genetic and epigenetic mechanisms. Therefore, understanding CRC’s molecular complexity is required to facilitate the development of novel therapeutic strategies to reduce drug resistance and enhance patient survival.
Dr. Premila Leiphrakpam
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor biology
- tumor heterogeneity
- molecular mechanism involved in cancer initiation, progression, and metastasis
- compensatory pathways
- cancer screening
- cancer biomarkers discovery
- tumor molecular profiling methods
- early cancer diagnosis
- novel therapeutic strategies
- targeted therapies
- drug resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
