Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 October 2024) | Viewed by 712
Special Issue Editor
Special Issue Information
Dear Colleagues,
Arterial hypertension is known as one of the main chronic diseases, affecting more than 1 billion people worldwide. The complications of this disease include cerebro-vascular stroke, coronary artery disease, heart failure, and kidney disease. These are major causes of morbidity and mortality all around the world. However, arterial blood pressure reduction in hypertensive people can prevent or drastically reduce these complications. Recent studies that were carried out on both humans and animal models showed that the increase in blood pressure is, at least in part, caused by an alteration of the endothelium at the level of the arterioles. This alteration is mainly due to an imbalance between the oxidizing and antioxidant substances normally produced by the body. An increase in oxidant substances, particularly reactive oxygen species (ROS), induces deterrent effects by triggering a cascade of signals that result in endothelial dysfunction that promotes the progression of cardiovascular disorders. Another important aspect is that the increase in pressure determines a geometric rearrangement of the vascular networks, impairing tissue perfusion.
The main aim of this Special Issue is to provide a broad overview of the mechanisms through which oxidative stress causes cardiovascular disorders and analyze the mechanisms underlying the regulatory effects of antioxidative natural substances. We warmly welcome submissions, including original papers and reviews, on this topic of such important public health interest.
Dr. Rossana Scuri
Guest Editor
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Keywords
- arteriolar networks organization
- blood flow supply
- cardiovascular disease
- endothelial dysfunction
- eNOS regulatory activity
- oxidative stress
- polyphenols
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