ijms-logo

Journal Browser

Journal Browser

Molecular Research of Reproductive Toxicity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 641

Special Issue Editors


E-Mail Website
Guest Editor
Department of Sciences and Technology, University Parthenope, 80133 Napoli, Italy
Interests: developmental biology; embriology; cells biology; histology; environmental toxicology; citotoxicology; heavy metals; cadmium; immunology, radiobiology; haevy ions; ionizing radiation; xenobiotic toxicity; radioprotection
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biology, University of Naples Federico II, Via Cintia 21, 80126 Napoli, Italy
Interests: developmental biology; cells biology; histology; environmental toxicology; citotoxicology; reproduction; endocrine disruptors; sexual hormones; testis; ovary; xenobiotic toxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, environmental pollution has represented a high risk for organism reproduction in aquatic and terrestrial environments. It could impact biodiversity, causing consequences for ecosystems at different levels, especially in areas where there is a higher concentration of environmental pollution. Understanding how chemical (drugs, microplastics, heavy metals) and physical (radiation, climate change) insults can disrupt normal development would help to safeguard the health of animal reproduction by improving risk assessments.

Focusing on the field of toxicology, this Special Issue focuses on all aspects of the reproductive and developmental effects induced by different environmental stressors, both chemical and physical. Molecular approaches to evaluate the impact on endocrine disruptors and reproductive disorders, including gametogenesis and sexual function and embryogenesis alterations, will be considered in in vitro and in vivo experiments using different model systems. Deep cytological and molecular investigations will be considered in order to clarify how exposure to different stressors can interfere with the mechanisms and gene expression regulation at basis of the correct processes of gametogenesis, fertilization and development, and how this exposure is responsible for hormone disorders, infertility or developmental malformations and teratogenesis.

This Special Issue will present original research articles, as well as mini and comprehensive reviews, including perspectives on biodiversity loss associated with failed reproductive success. New techniques to protect against and mitigate the impact of stressor agents and improve reproductive fitness are also welcome.

Prof. Dr. Palma Simoniello
Dr. Luigi Rosati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytotoxicity
  • environmental stressors
  • gametogenesis
  • thermal stress
  • apoptosis
  • embryos
  • developmental gene regulation
  • endocrine disruption
  • gene expression
  • larval development
  • reproductive toxicology
  • teratogenesis
  • xenobiotics
  • heavy metals

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 29438 KiB  
Article
Arginine Biosynthesis Mediates Wulingzhi Extract Resistance to Busulfan-Induced Male Reproductive Toxicity
by Zifang Wu, Yuxuan Ma, Shaoxian Chen, Yuyan Liu, Xianglin Liu, Heran Cao, Tianqi Jin, Long Li, Mengqi Huang, Fangxia Yang and Wuzi Dong
Int. J. Mol. Sci. 2024, 25(12), 6320; https://doi.org/10.3390/ijms25126320 - 7 Jun 2024
Viewed by 436
Abstract
Busulfan, an indispensable medicine in cancer treatment, can cause serious reproductive system damage to males as a side effect of its otherwise excellent therapeutic results. Its widespread use has also caused its accumulation in the environment and subsequent ecotoxicology effects. As a Chinese [...] Read more.
Busulfan, an indispensable medicine in cancer treatment, can cause serious reproductive system damage to males as a side effect of its otherwise excellent therapeutic results. Its widespread use has also caused its accumulation in the environment and subsequent ecotoxicology effects. As a Chinese medicine, Wulingzhi (WLZ) has the effects of promoting blood circulation and improving female reproductive function. However, the potential effects of WLZ in male reproduction and in counteracting busulfan-induced testis damage, as well as its probable mechanisms, are still ambiguous. In this study, busulfan was introduced in a mouse model to evaluate its production of the testicular damage. The components of different WLZ extracts were compared using an untargeted metabolome to select extracts with greater efficacy, which were further confirmed in vivo. Here, we demonstrate abnormal spermatogenesis and low sperm quality in busulfan-injured testes. The WLZ extracts showed a strong potential to rehabilitate the male reproductive system; this effect was more prominent in room-temperature extracts. Additionally, both water and ethanol WLZ extracts at room temperature alleviated various busulfan-induced adverse effects. In particular, WLZ recovered spermatogenesis, re-activated arginine biosynthesis, and alleviated the increased oxidative stress and inflammation in the testis, ultimately reversing the busulfan-induced testicular injury. Collectively, these results suggest a promising approach to protecting the male reproductive system from busulfan-induced adverse side effects, as well as those of other similar anti-cancer drugs. Full article
(This article belongs to the Special Issue Molecular Research of Reproductive Toxicity)
Show Figures

Figure 1

Back to TopTop