New Insights into Blood Disorders in Basic Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 2481
Special Issue Editors
Interests: leukemia and cancer; molecular mechanisms; TKI resistance; Dictyostelium discoideum model organism
Special Issues, Collections and Topics in MDPI journals
Interests: signal transduction; G-protein; GPCR; ubiquitin; peroxisome; lipid; Dictyostelium
Special Issues, Collections and Topics in MDPI journals
Interests: ubiquitination system; chemotaxis and aerotaxis; omics science; simple model; leukemia and cancer
Special Issues, Collections and Topics in MDPI journals
Interests: signal transduction; G-protein; ubiquitin; Dictyostelium; developmental biology; proteomic mass spectrometry; chemotaxis
Special Issue Information
Dear Colleagues,
Hematopoietic malignancies are heterogeneous disorders, usually characterized by genetic mutations in the hematopoietic stem cells (HSCs). The identification of novel markers has completely transformed the diagnosis, the prognosis, and the follow-up, thus becoming critical for monitoring the minimal residual disease and relapse. We would like to focus our attention on the no genetic alteration-driven processes that may be involved in leukemogenesis. In this regard, post-translational modifications, including phosphorylation, ubiquitination, and acetylation are fascinating mechanisms by which cells monitor essential pathways including cell cycle, apoptosis, and differentiation, and play a key role, when deregulated, in several pathologies, including blood disorders. Shedding light on this topic will help to figure out several unsolved issues.
Thus, in this special issue, we invite researchers to submit original research articles or reviews describing innovative functions of the non-genomic altered mechanisms and the processes regulating them (hypoxia, ubiquitin-proteasome system (UPS), autophagy, oxidative stress) in the leukemia field. Furthermore, research studies ranging from simple model organisms to human hematological diseases will be highly considered.
Dr. Cristina Panuzzo
Dr. Enrico Bracco
Dr. Barbara Pergolizzi
Dr. Alessandra Romano
Guest Editors
Manuscript Submission Information
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Keywords
- myeloproliferative neoplasms
- acute myeloid leukemia
- myelodisplastic sindrome
- post-translational modifications
- phosphorylation
- autophagy
- oxidative stress
- model organisms
- translational research
- oncosuppressors
- oncogenes
- drug therapies
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