New Insights into Blood Disorders in Basic Research

Dear Colleagues, 

Hematopoietic malignancies are heterogeneous disorders, usually characterized by genetic mutations in the hematopoietic stem cells (HSCs). The identification of novel markers has completely transformed the diagnosis, the prognosis, and the follow-up, thus becoming critical for monitoring the minimal residual disease and relapse. We would like to focus our attention on the no genetic alteration-driven processes that may be involved in leukemogenesis. In this regard, post-translational modifications, including phosphorylation, ubiquitination, and acetylation are fascinating mechanisms by which cells monitor essential pathways including cell cycle, apoptosis, and differentiation, and play a key role, when deregulated, in several pathologies, including blood disorders. Shedding light on this topic will help to figure out several unsolved issues.

Thus, in this special issue, we invite researchers to submit original research articles or reviews describing innovative functions of the non-genomic altered mechanisms and the processes regulating them (hypoxia, ubiquitin-proteasome system (UPS), autophagy, oxidative stress) in the leukemia field. Furthermore, research studies ranging from simple model organisms to human hematological diseases will be highly considered.

Dr. Cristina Panuzzo
Dr. Enrico Bracco
Dr. Barbara Pergolizzi
Dr. Alessandra Romano
Guest Editors

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• myeloproliferative neoplasms
• acute myeloid leukemia
• myelodisplastic sindrome
• post-translational modifications
• phosphorylation
• autophagy
• oxidative stress
• model organisms
• translational research
• oncosuppressors
• oncogenes
• drug therapies