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Glaucoma: Diagnostics and Therapeutic Perspectives
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Glaucoma: Diagnostics and Therapeutic Perspectives

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1704

Special Issue Editors

Prof. Dr. Barbara Cvenkel

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Guest Editor
1. Department of Ophthalmology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
2. Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
Interests: glaucoma
Prof. Dr. Miriam Kolko

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Guest Editor
1. Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark
2. Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark
Interests: glaucoma management; translational eye research; personalised medicine; biomarkers; retinal ganglion cells; Müller cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a great pleasure to invite you to contribute to the special issue "Glaucoma: Diagnostics and Therapeutic Perspectives".

Glaucoma is the second leading cause of blindness in people over 50 years of age worldwide, and with the aging population, this number will continue to rise, resulting in a reduced quality of life for these people and an increased social and economic burden on society. Since visual impairment from glaucoma is preventable, timely detection and treatment are critical. Currently, lowering intraocular pressure is the only clinically available treatment. Despite controlled intraocular pressure, some patients develop visual impairment during their lifetime.

This special issue addresses all aspects related to the diagnosis, treatment and future perspectives in the management of glaucoma. Authors are invited to submit high-quality original articles as well as reviews to advance knowledge in this field of research. 

Prof. Dr. Barbara Cvenkel
Prof. Dr. Miriam Kolko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glaucoma
  • visual field
  • intraocular pressure
  • glaucoma diagnosis
  • glaucoma treatment
  • personalized medicine

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Published Papers (1 paper)

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Research

18 pages, 2767 KiB  
Article
Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia
by Mia Langbøl, Jens Rovelt, Arevak Saruhanian, Sarkis Saruhanian, Daniel Tiedemann, Thisayini Baskaran, Cinzia Bocca, Rupali Vohra, Barbara Cvenkel, Guy Lenaers and Miriam Kolko
Int. J. Mol. Sci. 2024, 25(1), 195; https://doi.org/10.3390/ijms25010195 - 22 Dec 2023
Cited by 1 | Viewed by 1348
Abstract
Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role. The aim of [...] Read more.
Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role. The aim of the current study was to determine and compare the effect of universal hypoxia on the metabolomic signature in plasma samples from healthy controls (n = 10), patients with normal-tension glaucoma (NTG, n = 10), and ocular hypertension (OHT, n = 10). By subjecting humans to universal hypoxia, we aim to mimic a state in which the mitochondria in the body are universally stressed. Participants were exposed to normobaric hypoxia for two hours, followed by a 30 min recovery period in normobaric normoxia. Blood samples were collected at baseline, during hypoxia, and in recovery. Plasma samples were analyzed using a non-targeted metabolomics approach based on liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). Multivariate analyses were conducted using principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA), and univariate analysis using the Wilcoxon signed-rank test and false discovery rate (FDR) correction. Unique metabolites involved in fatty acid biosynthesis and ketone body metabolism were upregulated, while metabolites of the kynurenine pathway were downregulated in OHT patients exposed to universal hypoxia. Differential affection of metabolic pathways may explain why patients with OHT initially do not suffer or are more resilient from optic nerve degeneration. The metabolomes of NTG and OHT patients are regulated differently from control subjects and show dysregulation of metabolites important for energy production. These dysregulated processes may potentially contribute to the elevation of IOP and, ultimately, cell death of the RGCs. Full article
(This article belongs to the Special Issue Glaucoma: Diagnostics and Therapeutic Perspectives)
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